2,6-Dioxopiperidine-3-ammonium chloride synthesis
- Product Name:2,6-Dioxopiperidine-3-ammonium chloride
- CAS Number:24666-56-6
- Molecular formula:C5H9ClN2O2
- Molecular Weight:164.5902
24666-55-5
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$37.00/100mg
24666-56-6
446 suppliers
$8.00/5g
Yield:24666-56-6 100%
Reaction Conditions:
with hydrogenchloride;hydrogen;5% palladium over charcoal in methanol;water; under 3102.97 Torr; for 4 h;
Steps:
1
A solution of 15 (4.0Og, 0.015 mol) in methanol (200 ml) and 2N HCl (15 ml) was hydrogenated over 5% Pd-C (100 mg) at 60 psi for 4 h. The catalyst was filtered off and the filtrate concentrated to dryness to give the title compound 16 as a white solid (2.61 g, 100%), mp 245 0C (dec) (lit. 235 0C (dec)). 1H NMR (400 MHz, DMSO-D6) δ ppm 11.22 (br s? IH), 8.68 (br s, 3H), 4.20 (dd, J=13.0, 5.3 Hz, IH), 2.77-2.65 (m, IH), 2.64- 2.56 (m, IH), 2.27-2.19 (m, IH)5 2.09-1.97 (m, IH).
References:
WO2008/7979,2008,A1 Location in patent:Page/Page column 13
617-65-2
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24666-56-6
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31140-42-8
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$8.00/250mg
24666-56-6
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2650-64-8
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$10.00/5g
24666-56-6
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$8.00/5g
6398-06-7
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$89.59/1G
24666-56-6
446 suppliers
$8.00/5g