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ChemicalBook CAS DataBase List 2,6-Dibromopyridine
626-05-1

2,6-Dibromopyridine synthesis

8synthesis methods
-

Yield:-

Reaction Conditions:

with acetic acid

Steps:

1 EXAMPLE 1 SPC4
EXAMPLE 1 SPC4 7.4 g. (0.05 mol) of 2,6-dichloropyridine are admixed with 100 ml of anhydrous acetic acid. The reaction mixture is then heated to 110°C with exclusion of moisture. Hydrogen bromide gas is passed in continuously at this temperature for 9 hours while stirring the reaction mixture. The reaction product is then precipitated by pouring the reaction mixture onto ice, and is filtered off, washed with water and dried. 10.9 g (92% of theory) of 2,6-dibromopyridine, melting point 115°C, are obtained. Analysis for C5 H3 NBr2 (molecular weight 237): calculated C 25.34% H 1.28% N 5.91% Br 67.43% Cl - found C 25.3% H 1.4% N 5.9% Br 67.4% Cl<0.3

References:

Ciba-Geigy Corporation US3974166, 1976, A

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