ChemicalBook CAS DataBase List 2,4-DICHLOROBENZALDEHYDE OXIME

2,4-DICHLOROBENZALDEHYDE OXIME synthesis

5synthesis methods

Product Name:2,4-DICHLOROBENZALDEHYDE OXIME
CAS Number:56843-28-8
Molecular formula:C7H5Cl2NO
Molecular Weight:190.03

874-42-0
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$6.00/25g

56843-28-8
32 suppliers
$130.00/500mg

Yield:56843-28-8 98%

Reaction Conditions:

with hydroxylamine hydrochloride;sodium hydroxide in ethanol;water at 20; for 2 h;Cooling with ice;

Steps:

68

Reference Example-68
Hydroxylamine hydrochloride (748 mg, 10.4 mmol) was added to a solution of 2,4-dichlorobenzaldehyde (1.75 g, 9.49 mmol) in ethanol (10 mL) and water (10 mL), and a sodium hydroxide aqueous solution (37%, 1.8 mL) was added dropwise thereto under ice-cooling, followed by stirring at room temperature for 2 hours.
After the reaction was completed, 2N hydrochloric acid was added to the reaction solution to acidify, and the resultant product was extracted with dichloromethane (20 mL*2.10 mL*1).
The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure, whereby 2,4-dichlorobenzaldoxime (1.76 g, yield: 98%) was obtained as a white solid. ¹H-NMR (400 MHz, CDCl₃): δ7.26 (ddd, J=0.6, 2.2 and 8.7 Hz, 1H), 7.42 (d, J=2.2 Hz, 1H), 7.56 (s, 1H), 7.79 (d, J=8.7 Hz, 1H), 8.49 (s, 1H).

References:

US2016/24110,2016,A1 Location in patent:Paragraph 0950; 0951