ChemicalBook CAS DataBase List 2',3',5'-Tri-O-acetyl-D-adenosine

2',3',5'-Tri-O-acetyl-D-adenosine synthesis

12synthesis methods

Product Name:2',3',5'-Tri-O-acetyl-D-adenosine
CAS Number:7387-57-7
Molecular formula:C16H19N5O7
Molecular Weight:393.35

2466-76-4
355 suppliers
$13.00/5g

58-61-7 Synthesis

58-61-7
872 suppliers
$9.00/1g

7387-57-7
122 suppliers
$5.00/250mg

Yield: 74%

Reaction Conditions:

with sodium hydroxide in water; pH=8 at 20; for 4 h;

Steps:

General Nucleoside Acetylation Protocol
General procedure: Nucleoside/nucleotide (2; 100 mM) and N-acetyl imidazole (1a;10 equiv) were dissolved in water (pH 8; adjusted with 4 MNaOH). The solution was incubated at r.t. for 4 h, and NMR spectra were periodically acquired. The product was purified byreverse-phase (C18) flash coumn chromatography (eluted at pH4 with 100 mM NH4HCO2/MeCN = 98:2 to 80:20). The fractions containing 5 were lyophilised to yield a white powder.

References:

Fernández-García, Christian;Powner, Matthew W. [Synlett,2017,vol. 28,# 1,art. no. ST-2016-S0507-C,p. 78 - 83] Location in patent:supporting information