ChemicalBook CAS DataBase List 2,2'-Dihydroxy-4-methoxybenzophenone

2,2'-Dihydroxy-4-methoxybenzophenone synthesis

10synthesis methods

Product Name:2,2'-Dihydroxy-4-methoxybenzophenone
CAS Number:131-53-3
Molecular formula:C14H12O4
Molecular Weight:244.24

preparation by condensation of salicylic acid and m-methoxyphenol.

33077-87-1
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131-53-3
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Yield:131-53-3 85%

Reaction Conditions:

with hydrogen bromide;acetic acid at 110;Temperature;

Steps:

2.2 synthesis of 2, 2'-dihydroxy-4-methoxybenzophenone

Weighed 60 mL of glacial acetic acid and hydrobromic acid (48%) and 2, 2 ', 4-trimethoxybenzophenone(0.18 mol) in a three-necked flask, the reaction temperature was controlled at 110 ° C for 5 to 6 hours,The reaction mixture was cooled and washed with water to remove the acidic substance. The mixture was separated and extracted with ethyl acetate. After drying, the ethyl acetate was removed by evaporation to give an oily substance, which was recrystallized from 150 ml of n-hexane as a solvent and the temperature was controlled at 0 to 5 ° C Crystallization, filtration, drying under reduced pressure to get pale yellow crystalline powder 2, 2 '-dihydroxy-4-methoxybenzophenone 37. 3g.The yield was 85%, mp 67 ~ 69 ° C, and the content was 99.0% by HPLC.

References:

CN104058945,2016,B Location in patent:Paragraph 0028; 0029; 0031