(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid synthesis
- Product Name:(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid
- CAS Number:196404-55-4
- Molecular formula:C22H25NO6
- Molecular Weight:399.44
670254-71-4
37 suppliers
inquiry
196404-55-4
192 suppliers
$8.00/250mg
Yield:196404-55-4 92%
Reaction Conditions:
with methanol;sodium hydroxide at 20;
Steps:
6 Synthesis of benzooxazoline carboxylic acid
The above mention product 7 dissolved with ΜeOΗ, added dilute NaOH and stir at room temperature, TLC has been monitored after completion of the reaction and remove MeOH, the residue is diluted with Ac0Et / H20, static stratification. Into the aqueous phase added the AcOEt, and adjust the pH with dilute hydrochloric acid. The mixture is allowed to stand for separation, the organic phase has been separated, and the aqueous phase has been extracted with AcOEt, the combined organic phases are washed with water, dried over anhydrous MgS04, the solvent has been removed, and then obtained benzooxazoline carboxylic acid 8, yield of both steps is 92%.
References:
Jilin Pharmaceutical College;Fourth Military Medical University;Zhang Xiurong;Zhang Shengyong;Chen Ming;Jin Ying;Liang Chengwu;Chang Sheng;Li Xiaoye;Liu Xueying;Chen Weiping;Guan Shaoyu CN106632297, 2017, A Location in patent:Paragraph 0021
1531632-32-2
1 suppliers
inquiry
196404-55-4
192 suppliers
$8.00/250mg
124605-42-1
173 suppliers
$8.00/250mg
196404-55-4
192 suppliers
$8.00/250mg
157240-36-3
16 suppliers
inquiry
196404-55-4
192 suppliers
$8.00/250mg
![2-Propanesulfinamide, 2-methyl-N-(phenylmethylene)-, [S(R)]-](/CAS/20210305/GIF/196929-85-8.gif)
196929-85-8
0 suppliers
inquiry
196404-55-4
192 suppliers
$8.00/250mg