成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate
106685-41-0

Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate synthesis

10synthesis methods
-

Yield:106685-41-0 79%

Reaction Conditions:

in tetrahydrofuran;methanol at 0 - 20; for 1 h;

Steps:

1.5 Methyl 6-(3-(adamantan-l-yl)-4-methoxyphenyl)-2-naphthoate (5).
To a solution of adapalene (50 mg, 0.121 mmol) in 4: 1 THF/MeOH (0.4 mL) at 0 °C was added TMSCH2N2 (0.15 mL, 0.290 mmol) and the reaction was warmed to room temperature over 1 hour. The reaction mixture was concentrated, IN HCl was added, and was extracted with EtOAc 3x. The combined organic layers were washed with water and brine, dried over Na2S04, filtered, and concentrated; yielding the title compound as a white solid (41 mg, 79% yield). NMR (500 MHz, CDC13) δ 8.61 (s, 1H), 8.07 (dd, J = 8.6, 1.7 Hz, 1H), 8.03 - 7.96 (m, 2H), 7.92 (d, J = 8.6 Hz, 1H), 7.80 (dd, J = 8.5, 1.8 Hz, 1H), 7.60 (d, J = 2.4 Hz, 1H), 7.55 (dd, J = 8.4, 2.4 Hz, 1H), 7.00 (d, J = 8.5 Hz, 1H), 3.99 (s, 3H), 3.91 (s, 3H), 2.19 (s, 6H), 2.10 (s, 3H), 1.80 (s, 6H); 13C NMR (125 MHz, CDC13) δ 167.44, 159.03, 141.51, 139.11, 136.06, 132.67, 131.35, 130.95, 129.82, 128.33, 127.02, 126.59, 126.09, 125.84, 125.68, 124.84, 112.21, 55.27, 52.31, 40.72, 37.25, 29.23; HRMS Accurate mass (ES+): Found 427.2268, C29H3i03 (M+H+) requires 427.2273.

References:

AUSUBEL, Frederick M.;KIM, Wooseong;MYLONAKIS, Eleftherios;WUEST, William M. WO2018/213609, 2018, A1 Location in patent:Page/Page column 93

Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate Related Search: