Regorafenib monohydrate synthesis
- Product Name:Regorafenib monohydrate
- CAS Number:1019206-88-2
- Molecular formula:C21H17ClF4N4O4
- Molecular Weight:500.83
755037-03-7
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Yield:-
Reaction Conditions:
with water in acetoneProduct distribution / selectivity;
Steps:
1.1
400 mg of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N- methylpyridine-2-carboxamide in the polymorph I, prepared as described in WO 2005/009961, are dissolved in acetone and the solution is filtered. Water is added to one fourth of the filtrate until precipitation. The precipitate is filtered and dried at room temperature under ambient humidity. The sample is tested gravimetrically and corresponds to the title compound.
References:
BAYER HEALTHCARE AG WO2008/43446, 2008, A1 Location in patent:Page/Page column 19