ChemicalBook CAS DataBase List 1-CYCLOPROPYL-1-METHYLETHANOL

1-CYCLOPROPYL-1-METHYLETHANOL synthesis

14synthesis methods

Product Name:1-CYCLOPROPYL-1-METHYLETHANOL
CAS Number:930-39-2
Molecular formula:C6H12O
Molecular Weight:100.16

765-43-5 Synthesis

765-43-5
411 suppliers
$10.00/1g

75-16-1
270 suppliers
$12.00/10ml

930-39-2
50 suppliers
$45.00/10mg

Yield:930-39-2 92%

Reaction Conditions:

in diethyl ether at 20;Reflux;

Steps:

1

To a solution of 1-cyclopropylethan-1-one (1.0 g, 11.2 mmol) in anhydrous Et₂O (5 mL) was added a solution of MgMeBr (4.4 mL, 13.2 mmol) at a rate suitable to maintain gentle reflux of the solvent, to afford the expected alcoholate as a white precipitate. The reaction mixture was maintained refluxing for an additional 30 minutes, then stirred at RT overnight, and quenched with sat. NH₄Cl solution (5 mL). The resulting mixture was extracted with Et₂O (5 mL), and the combined organic layers were washed with brine (5 mL), dried over Na₂SO₄, and filtered. The filtrate was concentrated in vacuo to afford 2-cyclopropylpropan-2-ol as a pale yellow oil (1.1 g, 92%). ¹H NMR (500 MHz, CDCl₃) δ 1.18 (s, 6H), 0.97-0.94 (m, 1H), 0.39-0.30 (m, 4H).

References:

WO2017/176961,2017,A1 Location in patent:Paragraph 00228

917-64-6 Synthesis