ChemicalBook CAS DataBase List 1-(4-Hydroxyphenyl)-1-butanone

1-(4-Hydroxyphenyl)-1-butanone synthesis

7synthesis methods

Product Name:1-(4-Hydroxyphenyl)-1-butanone
CAS Number:1009-11-6
Molecular formula:C10H12O2
Molecular Weight:164.2

141-75-3
339 suppliers
$12.32/25G

108-95-2 Synthesis

108-95-2
737 suppliers
$14.00/25g

1009-11-6
204 suppliers
$11.00/5g

Yield:1009-11-6 98%

Reaction Conditions:

with trifluorormethanesulfonic acid at 0 - 20; for 1 h;regiospecific reaction;Friedel-Crafts acylation;

Steps:

4.3. General procedure of Friedel-Crafts acylation of phenols in TfOH

General procedure: Phenol (0.28 mmol) and acyl chloride (0.28 mmol) were dissolved in TfOH (3 ml) at 0 °C. The reaction mixture was warmed to room temperature for appropriate time in Table 2, then poured into cold water and ethyl acetate. The organic layer was washed with 1 M HCl, saturated NaHCO₃, and saturated NaCl, and dried over MgSO₄, then filtrated. The filtrate was concentrated and the residue was subjected silica column chromatography to afford acylated products. All spectral data were identical with the literatures.²⁷

References:

Murashige, Ryo;Hayashi, Yuka;Ohmori, Syo;Torii, Ayuko;Aizu, Yoko;Muto, Yasuyuki;Murai, Yuta;Oda, Yuji;Hashimoto, Makoto [Tetrahedron,2011,vol. 67,# 3,p. 641 - 649] Location in patent:experimental part

627-19-0 Synthesis