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ChemicalBook >> CAS DataBase List >> Tolbutamide-d9

Tolbutamide-d9

Tolbutamide-d9 price.
  • $73 - $1963.5
  • Product name: Tolbutamide-d9
  • CAS: 1219794-57-6
  • MF: C12H18N2O3S
  • MW: 270.35
  • EINECS:
  • MDL Number:
  • Synonyms:1-(Butyl-3-(p-tolyl- sulfonyl)urea-d9;3-(p-Tolyl-4-sulfonyl)-1-butylurea-d9;Artosin-d9;Artozin-d9;Mobenol-d9;N-[(ButylaMino-d9)carbonyl]-4-MethylbenzenesulfonaMide;N-Butyl-N'-(4-Methylphenylsulfonyl)urea-d9;Tolylsulfonylbutylurea-d9
9 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • Medical Isotopes, Inc.
  • TRC
Package
  • 1mg
  • 2.5MG
  • 5mg
  • 0.01g
  • 10mg
  • 25MG
  • 0.05g
  • ManufacturerAK Scientific
  • Product number5880DV
  • Product descriptionTolbutamide-d9
  • Packaging1mg
  • Price$179
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberBAR0001590
  • Product descriptionTOLBUTAMIDE-D9 95.00%
  • Packaging25MG
  • Price$1963.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberBAR0001590
  • Product descriptionTOLBUTAMIDE-D9 95.00%
  • Packaging2.5MG
  • Price$715
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number30738
  • Product descriptionTolbutamide-d9
  • Packaging1mg
  • Price$73
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number30738
  • Product descriptionTolbutamide-d9
  • Packaging5mg
  • Price$324
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number30738
  • Product descriptionTolbutamide-d9
  • Packaging10mg
  • Price$575
  • Updated2024-03-01
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product numberD2584
  • Product descriptionTolbutamide-d9(butyl-d9)
  • Packaging0.01g
  • Price$780
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product numberD2584
  • Product descriptionTolbutamide-d9(butyl-d9)
  • Packaging0.05g
  • Price$1700
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberT535152
  • Product descriptionTolbutamide-d9
  • Packaging25mg
  • Price$1355
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5880DV Tolbutamide-d9 1mg $179 2021-12-16 Buy
American Custom Chemicals Corporation BAR0001590 TOLBUTAMIDE-D9 95.00% 25MG $1963.5 2021-12-16 Buy
American Custom Chemicals Corporation BAR0001590 TOLBUTAMIDE-D9 95.00% 2.5MG $715 2021-12-16 Buy
Cayman Chemical 30738 Tolbutamide-d9 1mg $73 2024-03-01 Buy
Cayman Chemical 30738 Tolbutamide-d9 5mg $324 2024-03-01 Buy
Cayman Chemical 30738 Tolbutamide-d9 10mg $575 2024-03-01 Buy
Medical Isotopes, Inc. D2584 Tolbutamide-d9(butyl-d9) 0.01g $780 2021-12-16 Buy
Medical Isotopes, Inc. D2584 Tolbutamide-d9(butyl-d9) 0.05g $1700 2021-12-16 Buy
TRC T535152 Tolbutamide-d9 25mg $1355 2021-12-16 Buy

Properties

Melting point :108-111°C
storage temp. :Refrigerator
solubility :DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.14 mg/ml
form :A solid
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Tolbutamide-d9 is intended for use as an internal standard for the quantification of tolbutamide by GC- or LC-MS. Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 μM). It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 μM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets. In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; ). Formulations containing tolbutamide have been used in the treatment of type 2 diabetes.

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