Thiamphenicol
- $5 - $1000
- Product name: Thiamphenicol
- CAS: 15318-45-3
- MF: C12H15Cl2NO5S
- MW: 356.22
- EINECS:239-355-3
- MDL Number:MFCD00467983
- Synonyms:THIAMPHENICOL;methylsulfonyl chloramphenicol;D-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA-(HYDROXYMETHYL)-P-(METHYL-SULFONYL)PHENETHYL]ACETAMIDE;Acetamide, 2,2-dichloro-N-(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-4-(methylsulfonyl)phenylethyl-;d-threo-2,2-dichloro-n-(β-hydroxy-α-[hydroxymethyl]-4-[methylsulfonyl]phenethyl)acetamide;Acetamide, 2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl]- (9CI);Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl]-, [R-(R*,R*)]-;Acetamide, 2,2-dichloro-N-[b-hydroxy-a-(hydroxymethyl)-p-(methylsulfonyl)phenethyl]-, D-threo-(+)- (8CI)
37 prices
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Brand
- AHH
- AK Scientific
- Alfa Aesar
- Ambeed
- Biorbyt Ltd
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Usbiological
Package
- 50μg
- 100μg
- 500μg
- 100mg
- 250mg
- 500mg
- t1100000
- 500ul
- 1g
- 5g
- 10g
- 25g
- 50g
- 100g
- 250G
- 1000g
- ManufacturerAHH
- Product numberAPI-1001
- Product descriptionThiamphenicol 98%
- Packaging1000g
- Price$210
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberF386
- Product descriptionThiamphenicol
- Packaging25g
- Price$187
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ63575
- Product descriptionThiamphenicol
- Packaging1g
- Price$30.6
- Updated2024-03-01
- Buy
- ManufacturerAlfa Aesar
- Product numberJ63575
- Product descriptionThiamphenicol
- Packaging5g
- Price$65.4
- Updated2024-03-01
- Buy
- ManufacturerAlfa Aesar
- Product numberJ63575
- Product descriptionThiamphenicol
- Packaging25g
- Price$290
- Updated2024-03-01
- Buy
- ManufacturerAmbeed
- Product numberA216643
- Product description2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+%
- Packaging100mg
- Price$5
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA216643
- Product description2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+%
- Packaging1g
- Price$9
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA216643
- Product description2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+%
- Packaging5g
- Price$26
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA216643
- Product description2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+%
- Packaging25g
- Price$73
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA216643
- Product description2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+%
- Packaging100g
- Price$252
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb593363
- Product descriptionThiamphenicol
- Packaging50μg
- Price$425
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb593363
- Product descriptionThiamphenicol
- Packaging100μg
- Price$635.8
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb593363
- Product descriptionThiamphenicol
- Packaging500μg
- Price$957.1
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number21357
- Product descriptionThiamphenicol ≥98%
- Packaging5g
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21357
- Product descriptionThiamphenicol ≥98%
- Packaging10g
- Price$100
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21357
- Product descriptionThiamphenicol ≥98%
- Packaging25g
- Price$208
- Updated2024-03-01
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AHH | API-1001 | Thiamphenicol 98% | 1000g | $210 | 2021-12-16 | Buy |
AK Scientific | F386 | Thiamphenicol | 25g | $187 | 2021-12-16 | Buy |
Alfa Aesar | J63575 | Thiamphenicol | 1g | $30.6 | 2024-03-01 | Buy |
Alfa Aesar | J63575 | Thiamphenicol | 5g | $65.4 | 2024-03-01 | Buy |
Alfa Aesar | J63575 | Thiamphenicol | 25g | $290 | 2024-03-01 | Buy |
Ambeed | A216643 | 2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+% | 100mg | $5 | 2021-12-16 | Buy |
Ambeed | A216643 | 2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+% | 1g | $9 | 2021-12-16 | Buy |
Ambeed | A216643 | 2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+% | 5g | $26 | 2021-12-16 | Buy |
Ambeed | A216643 | 2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+% | 25g | $73 | 2021-12-16 | Buy |
Ambeed | A216643 | 2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+% | 100g | $252 | 2021-12-16 | Buy |
Biorbyt Ltd | orb593363 | Thiamphenicol | 50μg | $425 | 2021-12-16 | Buy |
Biorbyt Ltd | orb593363 | Thiamphenicol | 100μg | $635.8 | 2021-12-16 | Buy |
Biorbyt Ltd | orb593363 | Thiamphenicol | 500μg | $957.1 | 2021-12-16 | Buy |
Cayman Chemical | 21357 | Thiamphenicol ≥98% | 5g | $57 | 2024-03-01 | Buy |
Cayman Chemical | 21357 | Thiamphenicol ≥98% | 10g | $100 | 2024-03-01 | Buy |
Cayman Chemical | 21357 | Thiamphenicol ≥98% | 25g | $208 | 2024-03-01 | Buy |
Properties
Melting point :163-166 °C
alpha :D25 +12.9° (ethanol)
Density :1.3281 (rough estimate)
refractive index :1.6000 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :ethanol: 50 mg/mL, clear, colorless
form :powder
Boiling point :695.9±55.0 °C(Predicted)
pka :11.05±0.46(Predicted)
color :white to off-white
Water Solubility :Soluble in acetonitrile or DMF. Slightly soluble in water
Merck :14,9301
BRN :2819542
InChIKey :OTVAEFIXJLOWRX-NXEZZACHSA-N
CAS DataBase Reference :15318-45-3
EPA Substance Registry System :Thiamphenicol (15318-45-3)
alpha :D25 +12.9° (ethanol)
Density :1.3281 (rough estimate)
refractive index :1.6000 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :ethanol: 50 mg/mL, clear, colorless
form :powder
Boiling point :695.9±55.0 °C(Predicted)
pka :11.05±0.46(Predicted)
color :white to off-white
Water Solubility :Soluble in acetonitrile or DMF. Slightly soluble in water
Merck :14,9301
BRN :2819542
InChIKey :OTVAEFIXJLOWRX-NXEZZACHSA-N
CAS DataBase Reference :15318-45-3
EPA Substance Registry System :Thiamphenicol (15318-45-3)
Safety Information
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Description
Thiamphenicol is a broad-spectrum antibiotic chloramphenicol, which is more effective to the gram-negative bacteria than the gram-positive bacteria. At room temperature, it is a white to off-white crystalline powder or crystal, which can be quickly and completely absorped by oral adminstration, as well as it is excreted mainly in the prototype from the urine for metabolism. It is clinically applied for the treatment of respiratory, urinary tract, liver and gallbladder, typhoid and other intestinal surgery, gynecology and ENT infections. Especially in the mild infections it is more effective. It has the similar chemical structure with the chloramphenicol. Its methyl sulfone substituted the nitro of chloramphenicol, which reduced its toxicity, and in vivo its antibacterial activity is 2.5-5 times stronger than chloramphenicol. For gram-positive bacteria, such as streptococcus pneumoniae and hemolytic streptococcus, it has very strong antibacterial effect, while for gram-negative bacteria, such as Neisseria gonorrhoeae, meningococcus, lung Bacteroides, E. coli, Vibrio cholerae, Shigella and influenza bacillus, it also has strong antibacterial effect. For anaerobic bacteria, Rickettsia and amoeba, it has antibacterial effect in some extent. It has the same antimicrobial mechanism with chloramphenicol, which mainly inhibits the synthesis of bacterial protein. This drug is absorped quickly by oral administration, which reaches peak blood concentration within two hours. Its half-life is 5 hours, that is more longer than chloramphenicol. The bacteria have complete cross resistance to it and chloramphenicol, while the bacteria have some cross-resistance phenomenon to it and tetracycline.Thiamphenicol also has strong immunosuppressive effects, which is an excellent immunosuppressant. Its mechanism of action have significantly different with other immunosuppressive agents. The immunosuppressive effect is several times higher than the chloramphenicol. It can be as the effective extender for transplantation reaction and surgically allogeneic transplantation.
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Suppliers and manufacturers
Capot Chemical Co.,Ltd.
Shanghai Bojing Chemical Co.,Ltd.