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ChemicalBook >> CAS DataBase List >> Thiamphenicol

Thiamphenicol

Thiamphenicol price.
  • $5 - $1000
  • Product name: Thiamphenicol
  • CAS: 15318-45-3
  • MF: C12H15Cl2NO5S
  • MW: 356.22
  • EINECS:239-355-3
  • MDL Number:MFCD00467983
  • Synonyms:THIAMPHENICOL;methylsulfonyl chloramphenicol;D-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA-(HYDROXYMETHYL)-P-(METHYL-SULFONYL)PHENETHYL]ACETAMIDE;Acetamide, 2,2-dichloro-N-(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-4-(methylsulfonyl)phenylethyl-;d-threo-2,2-dichloro-n-(β-hydroxy-α-[hydroxymethyl]-4-[methylsulfonyl]phenethyl)acetamide;Acetamide, 2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl]- (9CI);Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl]-, [R-(R*,R*)]-;Acetamide, 2,2-dichloro-N-[b-hydroxy-a-(hydroxymethyl)-p-(methylsulfonyl)phenethyl]-, D-threo-(+)- (8CI)
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  • AHH
  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • Biorbyt Ltd
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • Usbiological
Package
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  • 500ul
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  • ManufacturerAHH
  • Product numberAPI-1001
  • Product descriptionThiamphenicol 98%
  • Packaging1000g
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberF386
  • Product descriptionThiamphenicol
  • Packaging25g
  • Price$187
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ63575
  • Product descriptionThiamphenicol
  • Packaging1g
  • Price$30.6
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ63575
  • Product descriptionThiamphenicol
  • Packaging5g
  • Price$65.4
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ63575
  • Product descriptionThiamphenicol
  • Packaging25g
  • Price$290
  • Updated2024-03-01
  • Buy
  • ManufacturerAmbeed
  • Product numberA216643
  • Product description2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+%
  • Packaging100mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA216643
  • Product description2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+%
  • Packaging1g
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA216643
  • Product description2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+%
  • Packaging5g
  • Price$26
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA216643
  • Product description2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+%
  • Packaging25g
  • Price$73
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA216643
  • Product description2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+%
  • Packaging100g
  • Price$252
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb593363
  • Product descriptionThiamphenicol
  • Packaging50μg
  • Price$425
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb593363
  • Product descriptionThiamphenicol
  • Packaging100μg
  • Price$635.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb593363
  • Product descriptionThiamphenicol
  • Packaging500μg
  • Price$957.1
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number21357
  • Product descriptionThiamphenicol ≥98%
  • Packaging5g
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21357
  • Product descriptionThiamphenicol ≥98%
  • Packaging10g
  • Price$100
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21357
  • Product descriptionThiamphenicol ≥98%
  • Packaging25g
  • Price$208
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH API-1001 Thiamphenicol 98% 1000g $210 2021-12-16 Buy
AK Scientific F386 Thiamphenicol 25g $187 2021-12-16 Buy
Alfa Aesar J63575 Thiamphenicol 1g $30.6 2024-03-01 Buy
Alfa Aesar J63575 Thiamphenicol 5g $65.4 2024-03-01 Buy
Alfa Aesar J63575 Thiamphenicol 25g $290 2024-03-01 Buy
Ambeed A216643 2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+% 100mg $5 2021-12-16 Buy
Ambeed A216643 2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+% 1g $9 2021-12-16 Buy
Ambeed A216643 2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+% 5g $26 2021-12-16 Buy
Ambeed A216643 2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+% 25g $73 2021-12-16 Buy
Ambeed A216643 2,2-Dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide 98+% 100g $252 2021-12-16 Buy
Biorbyt Ltd orb593363 Thiamphenicol 50μg $425 2021-12-16 Buy
Biorbyt Ltd orb593363 Thiamphenicol 100μg $635.8 2021-12-16 Buy
Biorbyt Ltd orb593363 Thiamphenicol 500μg $957.1 2021-12-16 Buy
Cayman Chemical 21357 Thiamphenicol ≥98% 5g $57 2024-03-01 Buy
Cayman Chemical 21357 Thiamphenicol ≥98% 10g $100 2024-03-01 Buy
Cayman Chemical 21357 Thiamphenicol ≥98% 25g $208 2024-03-01 Buy

Properties

Melting point :163-166 °C
alpha :D25 +12.9° (ethanol)
Density :1.3281 (rough estimate)
refractive index :1.6000 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :ethanol: 50 mg/mL, clear, colorless
form :powder
Boiling point :695.9±55.0 °C(Predicted)
pka :11.05±0.46(Predicted)
color :white to off-white
Water Solubility :Soluble in acetonitrile or DMF. Slightly soluble in water
Merck :14,9301
BRN :2819542
InChIKey :OTVAEFIXJLOWRX-NXEZZACHSA-N
CAS DataBase Reference :15318-45-3
EPA Substance Registry System :Thiamphenicol (15318-45-3)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Thiamphenicol is a broad-spectrum antibiotic chloramphenicol, which is more effective to the gram-negative bacteria than the gram-positive bacteria. At room temperature, it is a white to off-white crystalline powder or crystal, which can be quickly and completely absorped by oral adminstration, as well as it is excreted mainly in the prototype from the urine for metabolism. It is clinically applied for the treatment of respiratory, urinary tract, liver and gallbladder, typhoid and other intestinal surgery, gynecology and ENT infections. Especially in the mild infections it is more effective. It has the similar chemical structure with the chloramphenicol. Its methyl sulfone substituted the nitro of chloramphenicol, which reduced its toxicity, and in vivo its antibacterial activity is 2.5-5 times stronger than chloramphenicol. For gram-positive bacteria, such as streptococcus pneumoniae and hemolytic streptococcus, it has very strong antibacterial effect, while for gram-negative bacteria, such as Neisseria gonorrhoeae, meningococcus, lung Bacteroides, E. coli, Vibrio cholerae, Shigella and influenza bacillus, it also has strong antibacterial effect. For anaerobic bacteria, Rickettsia and amoeba, it has antibacterial effect in some extent. It has the same antimicrobial mechanism with chloramphenicol, which mainly inhibits the synthesis of bacterial protein. This drug is absorped quickly by oral administration, which reaches peak blood concentration within two hours. Its half-life is 5 hours, that is more longer than chloramphenicol. The bacteria have complete cross resistance to it and chloramphenicol, while the bacteria have some cross-resistance phenomenon to it and tetracycline.
Thiamphenicol also has strong immunosuppressive effects, which is an excellent immunosuppressant. Its mechanism of action have significantly different with other immunosuppressive agents. The immunosuppressive effect is several times higher than the chloramphenicol. It can be as the effective extender for transplantation reaction and surgically allogeneic transplantation.

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