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ChemicalBook >> CAS DataBase List >> TMC-207

TMC-207

TMC-207 price.
  • $40 - $2400
  • Product name: TMC-207
  • CAS: 843663-66-1
  • MF: C32H31BrN2O2
  • MW: 555.5
  • EINECS:1308068-626-2
  • MDL Number:
  • Synonyms:TMC-207;R 207910;Bedaquiline(R 207910,TMC 207);Bedaquiline (TMC-207);(αS,βR)-Bedaquiline ;bedaquinline;(1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol;Bedaquiline D6
33 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
  • AvaChem
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 10mM(in 1mL DMSO)
  • 1mg
  • 2mg
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 1g
  • ManufacturerAK Scientific
  • Product number9709BB
  • Product description(2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol
  • Packaging2mg
  • Price$104
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0010350
  • Product descriptionTMC-207 95.00%
  • Packaging5MG
  • Price$502.71
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3492
  • Product descriptionBedaquiline
  • Packaging5mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3492
  • Product descriptionBedaquiline
  • Packaging10mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3492
  • Product descriptionBedaquiline
  • Packaging10mM(in 1mL DMSO)
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3492
  • Product descriptionBedaquiline
  • Packaging50mg
  • Price$290
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0131
  • Product descriptionBedaquiline
  • Packaging2mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0131
  • Product descriptionBedaquiline
  • Packaging5mg
  • Price$138
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0131
  • Product descriptionBedaquiline
  • Packaging10mg
  • Price$196
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3375B
  • Product descriptionBedaquiline
  • Packaging5mg
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3375B
  • Product descriptionBedaquiline
  • Packaging10mg
  • Price$69
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3375B
  • Product descriptionBedaquiline
  • Packaging25mg
  • Price$109
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3375B
  • Product descriptionBedaquiline
  • Packaging100mg
  • Price$229
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3375B
  • Product descriptionBedaquiline
  • Packaging1g
  • Price$549
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB46540
  • Product description(1R,2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol
  • Packaging2mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB46540
  • Product description(1R,2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol
  • Packaging5mg
  • Price$75
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9709BB (2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol 2mg $104 2021-12-16 Buy
American Custom Chemicals Corporation API0010350 TMC-207 95.00% 5MG $502.71 2021-12-16 Buy
ApexBio Technology B3492 Bedaquiline 5mg $55 2021-12-16 Buy
ApexBio Technology B3492 Bedaquiline 10mg $75 2021-12-16 Buy
ApexBio Technology B3492 Bedaquiline 10mM(in 1mL DMSO) $80 2021-12-16 Buy
ApexBio Technology B3492 Bedaquiline 50mg $290 2021-12-16 Buy
Apolloscientific BISN0131 Bedaquiline 2mg $95 2021-12-16 Buy
Apolloscientific BISN0131 Bedaquiline 5mg $138 2021-12-16 Buy
Apolloscientific BISN0131 Bedaquiline 10mg $196 2021-12-16 Buy
AvaChem 3375B Bedaquiline 5mg $49 2021-12-16 Buy
AvaChem 3375B Bedaquiline 10mg $69 2021-12-16 Buy
AvaChem 3375B Bedaquiline 25mg $109 2021-12-16 Buy
AvaChem 3375B Bedaquiline 100mg $229 2021-12-16 Buy
AvaChem 3375B Bedaquiline 1g $549 2021-12-16 Buy
Biosynth Carbosynth FB46540 (1R,2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol 2mg $40 2021-12-16 Buy
Biosynth Carbosynth FB46540 (1R,2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol 5mg $75 2021-12-16 Buy

Properties

Melting point :104 °C
Boiling point :702.7±60.0 °C(Predicted)
Density :1.322±0.06 g/cm3(Predicted)
storage temp. :Room temperature
solubility :Soluble in DMSO (10 mg/ml)
form :solid
pka :13.05±0.29(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CAS DataBase Reference :843663-66-1

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P314 Get medical advice/attention if you feel unwell.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P391 Collect spillage. Hazardous to the aquatic environment
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

In December 2012, the US FDA approved bedaquiline as part of combination therapy for the treatment of multi-drug resistant tuberculosis (MDRTB). Bedaquiline is the first drug approved for MDR-TB and is the first approval from a new class of antituberculosis agents in the past 40 years. Due to the high unmetmedical need for treating MDR-TB, the FDA granted bedaquiline accelerated approval based on Phase II results, providing patients access to the drug while additional clinical studies are carried out. Bedaquiline (also known as TMC207 and R207910) is a diarylquinoline that was discovered from a high-throughput, whole-cell screening strategy with Mycobacterium smegmatis used as a surrogate for M. tuberculosis. Bedaquiline is a single enantiomer of an initial screening hit. Bedaquiline has potent and selective activity against mycobacteria, and is active against both drug-sensitive and drug-resistant M. tuberculosis. The mechanism of action of bedaquiline is unique amongst anti-TB drugs and involves inhibition of mycobacterial ATP synthase; it is not active against human ATP synthase. Bedaquiline has in vivo activity in numerous preclinical models of TB infection, alone and in combination with other anti-TB agents, and has bactericidal activity in established TB infection models. Bedaquiline is synthesized in five steps from 3-phenylpropionic acid and para-bromoaniline. Following amide formation, treatment with POCl3 and DMF under Vilsmeier–Hack conditions gave a 2-chloroquinoline product. Treatment with sodium methoxide, followed by condensation with 3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one, and separation of isomers gave bedaquiline.

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