N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
33 prices
-
Adipogen Life Sciences
-
AK Scientific
-
American Custom Chemicals Corporation
-
ApexBio Technology
-
Biorbyt Ltd
-
Biosynth Carbosynth
-
Cayman Chemical
-
Chemenu
-
ChemScene
-
Crysdot
-
DC Chemicals
-
TRC
- 5mg
- 10MG
- 1MG
- 10mM(in 1mL DMSO)
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
| Manufacturer |
Product number |
Product description |
Packaging |
Price |
Updated |
Buy |
|
Adipogen Life Sciences
| SYN-1010-M005 |
AT7519hydrochloride ≥95% |
5mg |
$108 |
2021-12-16 |
Buy |
|
AK Scientific
| SYN1010 |
AT-7519HCl |
50mg |
$560 |
2021-12-16 |
Buy |
|
AK Scientific
| SYN1010 |
AT-7519HCl |
100mg |
$890 |
2021-12-16 |
Buy |
|
American Custom Chemicals Corporation
| KIN0002512 |
4-(2,6-DICHLOROBENZAMIDO)-N-(PIPERIDIN-4-YL)-1H-PYRAZOLE-3-CARBOXAMIDE HYDROCHLORIDE 95.00% |
5MG |
$497.5 |
2021-12-16 |
Buy |
|
American Custom Chemicals Corporation
| API0005131 |
AT-7519 95.00% |
1MG |
$988.4 |
2021-12-16 |
Buy |
|
American Custom Chemicals Corporation
| API0005131 |
AT-7519 95.00% |
10MG |
$2025.29 |
2021-12-16 |
Buy |
|
ApexBio Technology
| A3197 |
AT7519Hydrochloride |
5mg |
$78 |
2021-12-16 |
Buy |
|
ApexBio Technology
| A3197 |
AT7519Hydrochloride |
10mM(in 1mL DMSO) |
$86 |
2021-12-16 |
Buy |
|
ApexBio Technology
| A3197 |
AT7519Hydrochloride |
10mg |
$117 |
2021-12-16 |
Buy |
|
ApexBio Technology
| A3197 |
AT7519Hydrochloride |
50mg |
$247 |
2021-12-16 |
Buy |
|
ApexBio Technology
| A3197 |
AT7519Hydrochloride |
100mg |
$325 |
2021-12-16 |
Buy |
|
Biorbyt Ltd
| orb146068 |
AT7519 HCL >99% |
100mg |
$606.9 |
2021-12-16 |
Buy |
|
Biorbyt Ltd
| orb146068 |
AT7519 HCL >99% |
250mg |
$912.9 |
2021-12-16 |
Buy |
|
Biorbyt Ltd
| orb146068 |
AT7519 HCL >99% |
1g |
$1802 |
2021-12-16 |
Buy |
|
Biosynth Carbosynth
| FD32785 |
4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide HCl |
25mg |
$70 |
2021-12-16 |
Buy |
|
Biosynth Carbosynth
| FD32785 |
4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide HCl |
50mg |
$110 |
2021-12-16 |
Buy |
Properties
storage temp. :Store at -20°C
solubility :≥29.93 mg/mL in H2O; ≥43.3 mg/mL in DMSO with ultrasonic; ≥8.82 mg/mL in EtOH with ultrasonic
form :crystalline solid
color :White to off-white
Safety Information
| Symbol(GHS): |
|
| Signal word: |
Warning |
| Hazard statements: |
| Code |
Hazard statements |
Hazard class |
Category |
Signal word |
Pictogram |
P-Codes |
| H302 |
Harmful if swallowed |
Acute toxicity,oral |
Category 4 |
Warning |
|
P264, P270, P301+P312, P330, P501 |
| H315 |
Causes skin irritation |
Skin corrosion/irritation |
Category 2 |
Warning |
|
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Causes serious eye irritation |
Serious eye damage/eye irritation |
Category 2A |
Warning |
|
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
May cause respiratory irritation |
Specific target organ toxicity, single exposure;Respiratory tract irritation |
Category 3 |
Warning |
|
|
|
| Precautionary statements: |
| P261 |
Avoid breathing dust/fume/gas/mist/vapours/spray. |
| P264 |
Wash hands thoroughly after handling. |
| P264 |
Wash skin thouroughly after handling. |
| P270 |
Do not eat, drink or smoke when using this product. |
| P271 |
Use only outdoors or in a well-ventilated area. |
| P280 |
Wear protective gloves/protective clothing/eye protection/face protection. |
| P301+P312 |
IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
| P302+P352 |
IF ON SKIN: wash with plenty of soap and water. |
| P304+P340 |
IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
| P305+P351+P338 |
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
| P321 |
Specific treatment (see … on this label). |
| P330 |
Rinse mouth. |
| P332+P313 |
IF SKIN irritation occurs: Get medical advice/attention. |
| P337+P313 |
IF eye irritation persists: Get medical advice/attention. |
| P403+P233 |
Store in a well-ventilated place. Keep container tightly closed. |
| P405 |
Store locked up. |
| P501 |
Dispose of contents/container to..… |
|
Description
AT7519 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) with IC50 values of 210, 47, 100, 13, 170, and <10 nM for Cdk1, 2, 4, 5, 6, and 9, respectively. It is less potent against Cdk3 and Cdk7 and inactive against non-Cdk kinases save for GSK3β (IC50 = 89 nM). AT7519 demonstrates antiproliferative activity against a wide variety of human tumor cell lines (IC50s = 40-940 nM in vitro), inhibiting cell cycle progression and inducing apoptosis, and prevents tumor growth in human tumor xenograft models. AT7519 induces activation of GSK3β by down-regulating GSK3β phosphorylation, which contributes to AT7519-induced apoptosis.
