SP2509
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- $32 - $2106
- Product name: SP2509
- CAS: 1423715-09-6
- MF: C19H20ClN3O5S
- MW: 437.9
- EINECS:-0
- MDL Number:MFCD28348370
- Synonyms:(E)-N'-(1-(5-chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide;HCI-2509;(E)-N'-(1-(5-chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide SP2509;SP2509;3-(4-Morpholinylsulfonyl)benzoic acid (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide;SP-2509;HCI-2509;SP 2509;SP-2509;CS-1755
24 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 2x5mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1212-M010
- Product descriptionSP2509 ≥95%
- Packaging10mg
- Price$421
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1212-M100
- Product descriptionSP2509 ≥95%
- Packaging100mg
- Price$2106
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1212
- Product descriptionSP2509
- Packaging100mg
- Price$1970
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4894
- Product descriptionSP2509
- Packaging10mM(in 1mL DMSO)
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2864
- Product descriptionSP2509 98%
- Packaging2x5mg
- Price$132
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546198
- Product descriptionSP2509 >98%
- Packaging5mg
- Price$190.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546198
- Product descriptionSP2509 >98%
- Packaging25mg
- Price$504.9
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15487
- Product descriptionSP2509 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15487
- Product descriptionSP2509 ≥98%
- Packaging5mg
- Price$86
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15487
- Product descriptionSP2509 ≥98%
- Packaging10mg
- Price$153
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15487
- Product descriptionSP2509 ≥98%
- Packaging25mg
- Price$343
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-3822
- Product descriptionSP2509 99.81%
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3822
- Product descriptionSP2509 99.81%
- Packaging10mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3822
- Product descriptionSP2509 99.81%
- Packaging50mg
- Price$270
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3822
- Product descriptionSP2509 99.81%
- Packaging100mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003530
- Product descriptionSP2509 98+%
- Packaging50mg
- Price$507
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1212-M010 | SP2509 ≥95% | 10mg | $421 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1212-M100 | SP2509 ≥95% | 100mg | $2106 | 2021-12-16 | Buy |
| AK Scientific | SYN1212 | SP2509 | 100mg | $1970 | 2021-12-16 | Buy |
| ApexBio Technology | B4894 | SP2509 | 10mM(in 1mL DMSO) | $105 | 2021-12-16 | Buy |
| Axon Medchem | Axon2864 | SP2509 98% | 2x5mg | $132 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546198 | SP2509 >98% | 5mg | $190.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546198 | SP2509 >98% | 25mg | $504.9 | 2021-12-16 | Buy |
| Cayman Chemical | 15487 | SP2509 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 15487 | SP2509 ≥98% | 5mg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 15487 | SP2509 ≥98% | 10mg | $153 | 2024-03-01 | Buy |
| Cayman Chemical | 15487 | SP2509 ≥98% | 25mg | $343 | 2024-03-01 | Buy |
| ChemScene | CS-3822 | SP2509 99.81% | 5mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-3822 | SP2509 99.81% | 10mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-3822 | SP2509 99.81% | 50mg | $270 | 2021-12-16 | Buy |
| ChemScene | CS-3822 | SP2509 99.81% | 100mg | $450 | 2021-12-16 | Buy |
| Crysdot | CD31003530 | SP2509 98+% | 50mg | $507 | 2021-12-16 | Buy |
Properties
Density :1.44±0.1 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :Off-white solid
pka :7.96±0.43(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :Off-white solid
pka :7.96±0.43(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4), resulting in transcriptional repression. SP2509 is a reversible inhibitor of LSD1 (IC50 = 13 nM). It has no effect on monoamine oxidases A and B. SP2509 attenuates the binding of LSD1 to CoREST, allowing increased methylation of H3K4 and driving increased expression of p21, p27, and CCAAT/enhancer binding protein α in cultured acute myeloid leukemia (AML) cells. It improves survival of mice with AML xenografts when given (25 mg/kg biweekly via intraperitoneal injection) for three weeks. Co-treatment of SP2509 with the pan-HDAC inhibitor panobinostat synergistically kills AML cells in vitro and improves survival of mice engrafted with AML cells.More related product prices
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