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ChemicalBook >> CAS DataBase List >> (+)-Camptothecin

(+)-Camptothecin

(+)-Camptothecin price.
  • $18 - $1900.44
  • Product name: (+)-Camptothecin
  • CAS: 7689-03-4
  • MF: C20H16N2O4
  • MW: 348.35
  • EINECS:444-280-6
  • MDL Number:MFCD00081076
  • Synonyms:CaMpetothecin;(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;CaMptothecin(NATURAL);4-ETHYL-4-HYDROXY-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-3,14(4H,12H)DIONE;5,6-DIHYDROXY-4-OXO-2-PHENYL-4H-1-BENZOPYRAN-7-YL BETA-D-GLUCOPYRANOSIDURONIC ACID;(+)-CAMPTOTHECIN;(s)-droxy ;1h-pyrano(3’,4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4-hy
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  • Adipogen Life Sciences
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  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0463-M050
  • Product description(S)-(+)-Camptothecin >98%(HPLC)
  • Packaging50mg
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0463-M250
  • Product description(S)-(+)-Camptothecin >98%(HPLC)
  • Packaging250mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ10012
  • Product description(S)-(+)-Camptothecin
  • Packaging1g
  • Price$155
  • Updated2021-12-16
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  • ManufacturerAK Scientific
  • Product numberK332
  • Product description(S)-(+)-Camptothecin
  • Packaging25g
  • Price$327
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ62523
  • Product descriptionCamptothecin
  • Packaging250mg
  • Price$91.3
  • Updated2023-06-20
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ62523
  • Product descriptionCamptothecin
  • Packaging1g
  • Price$180
  • Updated2023-06-20
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ62523
  • Product descriptionCamptothecin
  • Packaging5g
  • Price$712
  • Updated2023-06-20
  • Buy
  • ManufacturerAmbeed
  • Product numberA159794
  • Product description(S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging1g
  • Price$18
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA159794
  • Product description(S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging5g
  • Price$67
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA159794
  • Product description(S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging10g
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA159794
  • Product description(S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging25g
  • Price$266
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA159794
  • Product description(S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging100g
  • Price$1045
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0001826
  • Product descriptionCAMPTOTHECINE 95.00%
  • Packaging1G
  • Price$883.11
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0001826
  • Product descriptionCAMPTOTHECINE 95.00%
  • Packaging5G
  • Price$1900.44
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0001826
  • Product descriptionCAMPTOTHECINE 95.00%
  • Packaging5MG
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0001826
  • Product descriptionCAMPTOTHECINE 95.00%
  • Packaging250MG
  • Price$708.48
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CN2-0463-M050 (S)-(+)-Camptothecin >98%(HPLC) 50mg $25 2021-12-16 Buy
Adipogen Life Sciences AG-CN2-0463-M250 (S)-(+)-Camptothecin >98%(HPLC) 250mg $90 2021-12-16 Buy
AK Scientific J10012 (S)-(+)-Camptothecin 1g $155 2021-12-16 Buy
AK Scientific K332 (S)-(+)-Camptothecin 25g $327 2021-12-16 Buy
Alfa Aesar J62523 Camptothecin 250mg $91.3 2023-06-20 Buy
Alfa Aesar J62523 Camptothecin 1g $180 2023-06-20 Buy
Alfa Aesar J62523 Camptothecin 5g $712 2023-06-20 Buy
Ambeed A159794 (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 1g $18 2021-12-16 Buy
Ambeed A159794 (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 5g $67 2021-12-16 Buy
Ambeed A159794 (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 10g $120 2021-12-16 Buy
Ambeed A159794 (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 25g $266 2021-12-16 Buy
Ambeed A159794 (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 100g $1045 2021-12-16 Buy
American Custom Chemicals Corporation API0001826 CAMPTOTHECINE 95.00% 1G $883.11 2021-12-16 Buy
American Custom Chemicals Corporation API0001826 CAMPTOTHECINE 95.00% 5G $1900.44 2021-12-16 Buy
American Custom Chemicals Corporation API0001826 CAMPTOTHECINE 95.00% 5MG $550 2021-12-16 Buy
American Custom Chemicals Corporation API0001826 CAMPTOTHECINE 95.00% 250MG $708.48 2021-12-16 Buy

Properties

Melting point :260 °C (dec.)(lit.)
alpha :D25 +31.3° (in chloroform-methanol, 8:2)
Boiling point :482.73°C (rough estimate)
Density :1.3112 (rough estimate)
refractive index :1.5700 (estimate)
storage temp. :2-8°C
solubility :chloroform/methanol (4:1): 4 mg/mL
form :solid
pka :pKa 10.83 (Uncertain)
color :yellow
Water Solubility :insoluble
Merck :14,1735
BRN :631069
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :VSJKWCGYPAHWDS-FQEVSTJZSA-N
LogP :1.740
CAS DataBase Reference :7689-03-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.

Description

DNA topoisomerases relax DNA torsional strain created during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks enables anticancer agents to reversibly trap the complex by intercalating between DNA base pairs at the cleavage site, thus inhibiting religa Camptothecin is a cytotoxic, quinoline alkaloid, discovered as the active principle of extracts from the Chinese tree C. acuminate, that inhibits the DNA enzyme topoisomerase I (Top1). It binds the Top1-DNA cleavage complex, inducing DNA-strand breaks. Camptothecin has strong anti-tumor activity against a wide range of experimental tumors and inhibits both DNA and RNA synthesis in mammalian cells. It displays cytotoxity in HT-29 cells with an IC50 value of 10 nM and induces DNA damage at concentrations as low as 51 nM in whole cells and 12 nM in isolated nuclei in in vitro assays.

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