Ruxolitinib
|
- $25 - $2757.4
- Product name: Ruxolitinib
- CAS: 941678-49-5
- MF: C17H18N6
- MW: 306.37
- EINECS:1312995-182-4
- MDL Number:MFCD12031592
- Synonyms:(betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile;(3R)-3-(4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile;(3R)-3-cyclopentyl-3-(4-{7H-pyrrolo[2,3-d]pyriMidin-4-yl}-1H-pyrazol-1-yl)propanenitrile;INCB018424 (Ruxolitinib);β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-(βR)-1H-pyrazole-1-propanenitrile;(βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazole-1-propanenitrile;Ruxolitinib(INCB-018424);1H-Pyrazole-1-propanenitrile,.beta.-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-,(.beta.R)-
52 prices
Selected condition：
Brand
- AccelPharmtech
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
- Tocris
- TRC
Package
- 2.5MG
- 50
- 1mg
- 5mg
- 10MG
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1G
- 2g
- ManufacturerAccelPharmtech
- Product numberLW2807
- Product descriptionRuxolitinib 98%
- Packaging1G
- Price$1270
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1120-M005
- Product descriptionRuxolitinib ≥95%
- Packaging5mg
- Price$151
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1120-M050
- Product descriptionRuxolitinib ≥95%
- Packaging50mg
- Price$648
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ57064
- Product descriptionRuxolitinib
- Packaging5mg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberW9658
- Product descriptionRuxolitinib
- Packaging5mg
- Price$47
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA272323
- Product description(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile 98+%
- Packaging100mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA272323
- Product description(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile 98+%
- Packaging250mg
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA272323
- Product description(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile 98+%
- Packaging1g
- Price$380
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000439
- Product descriptionRUXOLITINIB 95.00%
- Packaging2.5MG
- Price$357
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000439
- Product descriptionRUXOLITINIB 95.00%
- Packaging10MG
- Price$773.97
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3012
- Product descriptionRuxolitinib(INCB018424)
- Packaging25mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIFK0027
- Product descriptionRuxolitinib
- Packaging5mg
- Price$58
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIFK0027
- Product descriptionRuxolitinib
- Packaging10mg
- Price$87
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIFK0027
- Product descriptionRuxolitinib
- Packaging25mg
- Price$174
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60063
- Product descriptionRuxolitinib(INCB018424) ≥98%
- Packaging10mg
- Price$168
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2597
- Product descriptionRuxolitinib
- Packaging5mg
- Price$29
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AccelPharmtech | LW2807 | Ruxolitinib 98% | 1G | $1270 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1120-M005 | Ruxolitinib ≥95% | 5mg | $151 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1120-M050 | Ruxolitinib ≥95% | 50mg | $648 | 2021-12-16 | Buy |
| AK Scientific | J57064 | Ruxolitinib | 5mg | $35 | 2021-12-16 | Buy |
| AK Scientific | W9658 | Ruxolitinib | 5mg | $47 | 2021-12-16 | Buy |
| Ambeed | A272323 | (R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile 98+% | 100mg | $90 | 2021-12-16 | Buy |
| Ambeed | A272323 | (R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile 98+% | 250mg | $185 | 2021-12-16 | Buy |
| Ambeed | A272323 | (R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile 98+% | 1g | $380 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000439 | RUXOLITINIB 95.00% | 2.5MG | $357 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000439 | RUXOLITINIB 95.00% | 10MG | $773.97 | 2021-12-16 | Buy |
| ApexBio Technology | A3012 | Ruxolitinib(INCB018424) | 25mg | $150 | 2021-12-16 | Buy |
| Apolloscientific | BIFK0027 | Ruxolitinib | 5mg | $58 | 2021-12-16 | Buy |
| Apolloscientific | BIFK0027 | Ruxolitinib | 10mg | $87 | 2021-12-16 | Buy |
| Apolloscientific | BIFK0027 | Ruxolitinib | 25mg | $174 | 2021-12-16 | Buy |
| Arctom | CFN60063 | Ruxolitinib(INCB018424) ≥98% | 10mg | $168 | 2021-12-16 | Buy |
| AvaChem | 2597 | Ruxolitinib | 5mg | $29 | 2021-12-16 | Buy |
Properties
Melting point :84-89°C
Density :1.40
storage temp. :-20°
solubility :Soluble in DMSO (up to 28 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
form :White powder.
pka :11.63±0.50(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI :InChI=1/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/s3
InChIKey :HFNKQEVNSGCOJV-UJHUVDBMNA-N
SMILES :[C@@H](C1CCCC1)(N1N=CC(C2N=CN=C3NC=CC=23)=C1)CC#N |&1:0,r|
CAS DataBase Reference :941678-49-5
Density :1.40
storage temp. :-20°
solubility :Soluble in DMSO (up to 28 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
form :White powder.
pka :11.63±0.50(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI :InChI=1/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/s3
InChIKey :HFNKQEVNSGCOJV-UJHUVDBMNA-N
SMILES :[C@@H](C1CCCC1)(N1N=CC(C2N=CN=C3NC=CC=23)=C1)CC#N |&1:0,r|
CAS DataBase Reference :941678-49-5
Safety Information
| Symbol(GHS): |
 
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Danger | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been linked to myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Ruxolitinib is a potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5 nM, respectively and is relatively less selective for JAK3 (IC50 = 322 nM). It can block interleukin-6 (IL-6) signaling (IC50 = 281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50 = 127 nM). In primary cultures, ruxolitinib preferentially suppresses erythroid progenitor colony formation from JAK2V617F+ polycythemia vera patients (IC50 = 67 nM) versus healthy donors (IC50 > 400 nM). In a mouse model of JAK2V617F+ MPN, 90 mg/kg ruxolitinib reduced splenomegaly, decreased circulating levels of IL-6 and TNF-α, eliminated neoplastic cells, and prolonged survival of the treated animals.More related product prices
871700-17-3 Dasatinib MK-2206 2HCl Y27632 (hydrochloride) Bortezomib Ibrutinib Gefitinib Abiraterone Lenalidomide Ponatinib Ruxolitinib phosphate Calcium dobesilate Posaconazole 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol DL-Malic acid 283173-50-2 PF-01367338Related product price
- 871700-17-3
$28-4391.1 - Dasatinib
$9-4498.73 - MK-2206 2HCl
$10-5132
Suppliers and manufacturers
Zhengzhou Anhuida Chemical Co., Ltd
TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD
