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ChemicalBook >> CAS DataBase List >> RET Kinase inhibitor 1

RET Kinase inhibitor 1

RET Kinase inhibitor 1 price.
  • $32 - $3200
  • Product name: RET Kinase inhibitor 1
  • CAS: 1627856-64-7
  • MF: C22H21F4N3O4
  • MW: 467.41
  • EINECS:
  • MDL Number:MFCD30747847
  • Synonyms:RET Kinase inhibitor 1;CS-2597;c-RET inhibitor GS3179106;GSK3179106;GSK-3179106;Benzeneacetamide, 4-(4-ethoxy-1,6-dihydro-6-oxo-3-pyridinyl)-2-fluoro-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]-;syndrome,post-inflammatory,visceral,stress-induced,irritable,RET,Inhibitor,bowel,hypersensitivity,orally,GSK 3179106,inhibit,IBS,GSK3179106,GSK-3179106
14 prices
Selected condition:
Brand
  • AK Scientific
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number1815DY
  • Product descriptionRETKinaseinhibitor1
  • Packaging1mg
  • Price$133
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number1815DY
  • Product descriptionRETKinaseinhibitor1
  • Packaging5mg
  • Price$252
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number24023
  • Product descriptionRET Kinase Inhibitor 1
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number24023
  • Product descriptionRET Kinase Inhibitor 1
  • Packaging5mg
  • Price$139
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number24023
  • Product descriptionRET Kinase Inhibitor 1
  • Packaging10mg
  • Price$243
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number24023
  • Product descriptionRET Kinase Inhibitor 1
  • Packaging25mg
  • Price$533
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7799
  • Product descriptionGSK3179106 99.40%
  • Packaging1mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7799
  • Product descriptionGSK3179106 99.40%
  • Packaging5mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7799
  • Product descriptionGSK3179106 99.40%
  • Packaging10mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7799
  • Product descriptionGSK3179106 99.40%
  • Packaging50mg
  • Price$800
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7799
  • Product descriptionGSK3179106 99.40%
  • Packaging100mg
  • Price$1450
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10936
  • Product descriptionGSK3179106 >98%
  • Packaging100mg
  • Price$950
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10936
  • Product descriptionGSK3179106 >98%
  • Packaging250mg
  • Price$1700
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10936
  • Product descriptionGSK3179106 >98%
  • Packaging1g
  • Price$3200
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1815DY RETKinaseinhibitor1 1mg $133 2021-12-16 Buy
AK Scientific 1815DY RETKinaseinhibitor1 5mg $252 2021-12-16 Buy
Cayman Chemical 24023 RET Kinase Inhibitor 1 1mg $32 2024-03-01 Buy
Cayman Chemical 24023 RET Kinase Inhibitor 1 5mg $139 2024-03-01 Buy
Cayman Chemical 24023 RET Kinase Inhibitor 1 10mg $243 2024-03-01 Buy
Cayman Chemical 24023 RET Kinase Inhibitor 1 25mg $533 2024-03-01 Buy
ChemScene CS-7799 GSK3179106 99.40% 1mg $50 2021-12-16 Buy
ChemScene CS-7799 GSK3179106 99.40% 5mg $110 2021-12-16 Buy
ChemScene CS-7799 GSK3179106 99.40% 10mg $200 2021-12-16 Buy
ChemScene CS-7799 GSK3179106 99.40% 50mg $800 2021-12-16 Buy
ChemScene CS-7799 GSK3179106 99.40% 100mg $1450 2021-12-16 Buy
DC Chemicals DC10936 GSK3179106 >98% 100mg $950 2021-12-16 Buy
DC Chemicals DC10936 GSK3179106 >98% 250mg $1700 2021-12-16 Buy
DC Chemicals DC10936 GSK3179106 >98% 1g $3200 2021-12-16 Buy

Properties

Boiling point :670.1±55.0 °C(Predicted)
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO:81.0(Max Conc. mg/mL);173.29(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.53(Max Conc. mM)
Ethanol:15.5(Max Conc. mg/mL);33.16(Max Conc. mM) form :A crystalline solid
pka :10.30±0.10(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

GSK3179106 is an inhibitor of rearranged during transfection (RET) kinase (IC50 = 0.4 nM). It is selective for RET kinase over VEGF receptor 2 (VEGFR2/KDR; IC50 = 109 nM). GSK3179106 reduces the number of abdominal contractions induced by colorectal distension in acetic acid-sensitized rats when administered at a dose of 10 mg/kg twice per day.