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ChemicalBook >> CAS DataBase List >> N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide price.
22 prices
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  • AK Scientific
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product number3708AH
  • Product descriptionN-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide
  • Packaging50mg
  • Price$556
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3708AH
  • Product descriptionN-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide
  • Packaging10mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5833
  • Product descriptionGSK503
  • Packaging10mM(in 1mL DMSO)
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFG137681
  • Product descriptionGSK 503
  • Packaging10mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFG137681
  • Product descriptionGSK 503
  • Packaging50mg
  • Price$375
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18531
  • Product descriptionGSK503 ≥98%
  • Packaging25mg
  • Price$456
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18531
  • Product descriptionGSK503 ≥98%
  • Packaging10mg
  • Price$243
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18531
  • Product descriptionGSK503 ≥98%
  • Packaging5mg
  • Price$139
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18531
  • Product descriptionGSK503 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4179
  • Product descriptionGSK503 99.73%
  • Packaging5mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4179
  • Product descriptionGSK503 99.73%
  • Packaging10mg
  • Price$156
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4179
  • Product descriptionGSK503 99.73%
  • Packaging50mg
  • Price$540
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4179
  • Product descriptionGSK503 99.73%
  • Packaging100mg
  • Price$960
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003799
  • Product descriptionGSK503 98+%
  • Packaging100mg
  • Price$965
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003799
  • Product descriptionGSK503 98+%
  • Packaging50mg
  • Price$568
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8044
  • Product descriptionGSK503 >98%
  • Packaging100mg
  • Price$650
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3708AH N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide 50mg $556 2021-12-16 Buy
AK Scientific 3708AH N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide 10mg $218 2021-12-16 Buy
ApexBio Technology B5833 GSK503 10mM(in 1mL DMSO) $150 2021-12-16 Buy
Biosynth Carbosynth FG137681 GSK 503 10mg $125 2021-12-16 Buy
Biosynth Carbosynth FG137681 GSK 503 50mg $375 2021-12-16 Buy
Cayman Chemical 18531 GSK503 ≥98% 25mg $456 2024-03-01 Buy
Cayman Chemical 18531 GSK503 ≥98% 10mg $243 2024-03-01 Buy
Cayman Chemical 18531 GSK503 ≥98% 5mg $139 2024-03-01 Buy
Cayman Chemical 18531 GSK503 ≥98% 1mg $32 2024-03-01 Buy
ChemScene CS-4179 GSK503 99.73% 5mg $108 2021-12-16 Buy
ChemScene CS-4179 GSK503 99.73% 10mg $156 2021-12-16 Buy
ChemScene CS-4179 GSK503 99.73% 50mg $540 2021-12-16 Buy
ChemScene CS-4179 GSK503 99.73% 100mg $960 2021-12-16 Buy
Crysdot CD31003799 GSK503 98+% 100mg $965 2021-12-16 Buy
Crysdot CD31003799 GSK503 98+% 50mg $568 2021-12-16 Buy
DC Chemicals DC8044 GSK503 >98% 100mg $650 2021-12-16 Buy

Properties

Boiling point :798.6±60.0 °C(Predicted)
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥21.65 mg/mL in DMSO; insoluble in H2O; ≥26.85 mg/mL in EtOH with gentle warming
form :solid
pka :11.93±0.10(Predicted)
color :White to gray

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

The lysine methyltransferase EZH2 (KMT6), part of the polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 (H3K27me3) and is involved in proliferation and aggressive cell growth associated with neoplastic cells. GSK503 is an inhibitor of EZH2 that prevents the methyltransferase activity of wild-type and mutant EZH2 with similar potency (Kiapp = 3-27 nM). It is more than 200-fold selective for EZH2 over EZH1 and more than 4,000-fold selective over other histone methyltransferases. GSK503 displays favorable pharmacokinetics in mice. It prevents germinal center formation and hyperplasia that is relevant to lymphoma generation and inhibits growth and metastasis of cutaneous melanomas in mice.