ML-228
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- $32 - $2500
- Product name: ML-228
- CAS: 1357171-62-0
- MF: C27H21N5
- MW: 415.49
- EINECS:
- MDL Number:MFCD26792570
- Synonyms:ML-228;N-([1,1-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine;ML228; ML 228;N-([1,1'Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine;CID-46742353;ML-228;CID-46742353;L-228;1,2,4-Triazin-5-amine, N-([1,1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-
24 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Tocris
- Usbiological
Package
- 10
- 1mg
- 5mg
- 50
- 10mg
- 50mg
- 100mg
- 1g
- ManufacturerAK Scientific
- Product number3862AH
- Product descriptionN-([1,1'-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine
- Packaging50mg
- Price$1197
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3862AH
- Product descriptionN-([1,1'-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine
- Packaging5mg
- Price$243
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3862AH
- Product descriptionN-([1,1'-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine
- Packaging1mg
- Price$133
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4508
- Product descriptionML228
- Packaging5mg
- Price$156
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4508
- Product descriptionML228
- Packaging10mg
- Price$276
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4508
- Product descriptionML228
- Packaging50mg
- Price$1134
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4508
- Product descriptionML228
- Packaging100mg
- Price$1764
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14568
- Product descriptionML-228 ≥95%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14568
- Product descriptionML-228 ≥95%
- Packaging5mg
- Price$131
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14568
- Product descriptionML-228 ≥95%
- Packaging10mg
- Price$230
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14568
- Product descriptionML-228 ≥95%
- Packaging50mg
- Price$987
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-3939
- Product descriptionML228 >98.0%
- Packaging5mg
- Price$119
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3939
- Product descriptionML228 >98.0%
- Packaging10mg
- Price$210
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3939
- Product descriptionML228 >98.0%
- Packaging50mg
- Price$864
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3939
- Product descriptionML228 >98.0%
- Packaging100mg
- Price$1344
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003754
- Product descriptionML228 98+%
- Packaging5mg
- Price$69
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3862AH | N-([1,1'-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine | 50mg | $1197 | 2021-12-16 | Buy |
| AK Scientific | 3862AH | N-([1,1'-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine | 5mg | $243 | 2021-12-16 | Buy |
| AK Scientific | 3862AH | N-([1,1'-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine | 1mg | $133 | 2021-12-16 | Buy |
| ApexBio Technology | A4508 | ML228 | 5mg | $156 | 2021-12-16 | Buy |
| ApexBio Technology | A4508 | ML228 | 10mg | $276 | 2021-12-16 | Buy |
| ApexBio Technology | A4508 | ML228 | 50mg | $1134 | 2021-12-16 | Buy |
| ApexBio Technology | A4508 | ML228 | 100mg | $1764 | 2021-12-16 | Buy |
| Cayman Chemical | 14568 | ML-228 ≥95% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 14568 | ML-228 ≥95% | 5mg | $131 | 2024-03-01 | Buy |
| Cayman Chemical | 14568 | ML-228 ≥95% | 10mg | $230 | 2024-03-01 | Buy |
| Cayman Chemical | 14568 | ML-228 ≥95% | 50mg | $987 | 2024-03-01 | Buy |
| ChemScene | CS-3939 | ML228 >98.0% | 5mg | $119 | 2021-12-16 | Buy |
| ChemScene | CS-3939 | ML228 >98.0% | 10mg | $210 | 2021-12-16 | Buy |
| ChemScene | CS-3939 | ML228 >98.0% | 50mg | $864 | 2021-12-16 | Buy |
| ChemScene | CS-3939 | ML228 >98.0% | 100mg | $1344 | 2021-12-16 | Buy |
| Crysdot | CD31003754 | ML228 98+% | 5mg | $69 | 2021-12-16 | Buy |
Properties
Boiling point :686.0±65.0 °C(Predicted)
Density :1.228±0.06 g/cm3(Predicted)
storage temp. :-20°C, Inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :2.03±0.63(Predicted)
color :Pale Yellow to Light Yellow
Density :1.228±0.06 g/cm3(Predicted)
storage temp. :-20°C, Inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :2.03±0.63(Predicted)
color :Pale Yellow to Light Yellow
Safety Information
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Description
The hypoxia-inducible factor (HIF) transcription factors are members of the basic-helix-loop-helix (bHLH) family of transcription factors and play important roles in maintaining cellular oxygen homeostasis. HIF-1α has emerged as an important drug target in breast and prostate cancer, cardiovascular disease, and ischemia. ML-228 is an activator of the HIF signaling pathway, as demonstrated by HIF response element (HRE) reporter assay (EC50 = 1.2 μM), HIF-1α nuclear translocation assay (EC50 = 1.3 μM), and increased VEGF expression (EC50 = 1.6 μM). Its activity in the HRE assay is blocked by excess iron, suggesting that ML-228 can chelate iron. Molecular modeling indicates that ML-228 does not modulate HIF signaling by binding to prolyl hydroxyases. ML-228 also significantly inhibits ligand binding to several channels, receptors, and transporters, including ERG potassium channel, 5-HT2B and A3 adenosine receptors, and dopamine transporter.Related product price
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