LDN 193189 hydrochloride
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- $25 - $920
- Product name: LDN 193189 hydrochloride
- CAS: 1435934-00-1
- MF: C25H24Cl2N6
- MW: 479.40426
- EINECS:
- MDL Number:
- Synonyms:LDN-193189 2HCl;LDN 193189 dihydrochloride;4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride;Viomycin LDN 193189 Dihydrochloride;DM-3189 2HCl;LDN-193189 2HC;LDN-193189 (DM3189) 2HCl;LDN-193189 2HCl|||DM-3189 2HCl
9 prices
Selected condition：
Brand
- AK Scientific
- Biosynth Carbosynth
- Cayman Chemical
- Tocris
Package
- 50
- 1mg
- 5mg
- 10mg
- 25mg
- 10
- 50mg
- ManufacturerAK Scientific
- Product number3810EC
- Product description4-[6-(4-Piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline;dihydrochloride
- Packaging50mg
- Price$920
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBL162781
- Product descriptionLDN 193189 dihydrochloride
- Packaging10mg
- Price$145
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBL162781
- Product descriptionLDN 193189 dihydrochloride
- Packaging50mg
- Price$645
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19396
- Product descriptionLDN-193189 (hydrochloride)
- Packaging1mg
- Price$25
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19396
- Product descriptionLDN-193189 (hydrochloride)
- Packaging5mg
- Price$56
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19396
- Product descriptionLDN-193189 (hydrochloride)
- Packaging10mg
- Price$100
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19396
- Product descriptionLDN-193189 (hydrochloride)
- Packaging25mg
- Price$219
- Updated2024-03-01
- Buy
- ManufacturerTocris
- Product number6053
- Product descriptionLDN193189dihydrochloride ≥98%(HPLC)
- Packaging10
- Price$216
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number6053
- Product descriptionLDN193189dihydrochloride ≥98%(HPLC)
- Packaging50
- Price$850
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3810EC | 4-[6-(4-Piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline;dihydrochloride | 50mg | $920 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BL162781 | LDN 193189 dihydrochloride | 10mg | $145 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BL162781 | LDN 193189 dihydrochloride | 50mg | $645 | 2021-12-16 | Buy |
| Cayman Chemical | 19396 | LDN-193189 (hydrochloride) | 1mg | $25 | 2024-03-01 | Buy |
| Cayman Chemical | 19396 | LDN-193189 (hydrochloride) | 5mg | $56 | 2024-03-01 | Buy |
| Cayman Chemical | 19396 | LDN-193189 (hydrochloride) | 10mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 19396 | LDN-193189 (hydrochloride) | 25mg | $219 | 2024-03-01 | Buy |
| Tocris | 6053 | LDN193189dihydrochloride ≥98%(HPLC) | 10 | $216 | 2021-12-16 | Buy |
| Tocris | 6053 | LDN193189dihydrochloride ≥98%(HPLC) | 50 | $850 | 2021-12-16 | Buy |
Properties
storage temp. :-20°C
solubility :Soluble in DMSO or in Water (up to 5 mg/ml)
form :solid
color :Orange-yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
solubility :Soluble in DMSO or in Water (up to 5 mg/ml)
form :solid
color :Orange-yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
Safety Information
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Description
LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.More related product prices
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