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ChemicalBook >> CAS DataBase List >> KYNURENIC ACID

KYNURENIC ACID

KYNURENIC ACID price.
  • $20.6 - $540
  • Product name: KYNURENIC ACID
  • CAS: 492-27-3
  • MF: C10H7NO3
  • MW: 189.17
  • EINECS:207-751-5
  • MDL Number:MFCD00006753
  • Synonyms:KYNURENIC ACID;2-Carboxy-4-hydroxyquinoline;4-Hydroxyquinaldinic Acid;NSC 58973;4-Hydroxyquinaldic Acid 4-Hydroxyquinoline-2-carboxylic Acid;4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID FOR;4-keto-1H-quinoline-2-carboxylic acid;4-oxo-1H-quinoline-2-carboxylic acid
21 prices
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  • Absolute Chiral
  • AHH
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Chemcia Scientific
  • ChemScene
  • Crysdot
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  • DC Chemicals
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
Package
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  • ManufacturerAbsolute Chiral
  • Product numberO1917-00-N
  • Product description4-Hydroxyquinoline-2-carboxylicacid techgrade
  • Packaging100mg
  • Price$68
  • Updated2021-12-16
  • Buy
  • ManufacturerAHH
  • Product numberMT-15575
  • Product description4-Hydroxyquinoline-2-carboxylicacid 98%
  • Packaging50g
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberW6496
  • Product description4-Hydroxy-2-quinolincarboxylicacid
  • Packaging1g
  • Price$41
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6227
  • Product descriptionKynurenic acid
  • Packaging1g
  • Price$98
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN90072
  • Product descriptionKynurenic acid ≥98%
  • Packaging20mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerChemcia Scientific
  • Product numberCC00-6079B
  • Product description4-Hydroxy-quinoline-2-carboxylicacid 95%
  • Packaging5G
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerChemcia Scientific
  • Product numberCC00-6079B
  • Product description4-Hydroxy-quinoline-2-carboxylicacid 95%
  • Packaging10g
  • Price$195
  • Updated2021-12-16
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  • ManufacturerChemScene
  • Product numberCS-W020664
  • Product descriptionKynurenic acid 99.03%
  • Packaging1g
  • Price$90
  • Updated2021-12-16
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  • ManufacturerChemScene
  • Product numberCS-W020664
  • Product descriptionKynurenic acid 99.03%
  • Packaging5g
  • Price$270
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-W020664
  • Product descriptionKynurenic acid 99.03%
  • Packaging10g
  • Price$540
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11117095
  • Product descriptionKynurenic acid 95+%
  • Packaging100mg
  • Price$90
  • Updated2021-12-16
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  • ManufacturerCSNpharm
  • Product numberCSN10840
  • Product descriptionKynurenic acid
  • Packaging25mg
  • Price$35
  • Updated2021-12-16
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  • ManufacturerDC Chemicals
  • Product numberDC9889
  • Product descriptionKynurenic acid >98%
  • Packaging100mg
  • Price$180
  • Updated2021-12-16
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  • ManufacturerSigma-Aldrich
  • Product numberK3375
  • Product descriptionKynurenic acid ≥98%
  • Packaging250mg
  • Price$20.6
  • Updated2024-03-01
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  • ManufacturerSigma-Aldrich
  • Product numberK3375
  • Product descriptionKynurenic acid ≥98%
  • Packaging1g
  • Price$47.1
  • Updated2024-03-01
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  • ManufacturerSigma-Aldrich
  • Product number67667
  • Product descriptionKynurenic acid analytical standard
  • Packaging10mg
  • Price$75.3
  • Updated2022-05-15
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Absolute Chiral O1917-00-N 4-Hydroxyquinoline-2-carboxylicacid techgrade 100mg $68 2021-12-16 Buy
AHH MT-15575 4-Hydroxyquinoline-2-carboxylicacid 98% 50g $320 2021-12-16 Buy
AK Scientific W6496 4-Hydroxy-2-quinolincarboxylicacid 1g $41 2021-12-16 Buy
ApexBio Technology B6227 Kynurenic acid 1g $98 2021-12-16 Buy
Arctom CFN90072 Kynurenic acid ≥98% 20mg $40 2021-12-16 Buy
Chemcia Scientific CC00-6079B 4-Hydroxy-quinoline-2-carboxylicacid 95% 5G $105 2021-12-16 Buy
Chemcia Scientific CC00-6079B 4-Hydroxy-quinoline-2-carboxylicacid 95% 10g $195 2021-12-16 Buy
ChemScene CS-W020664 Kynurenic acid 99.03% 1g $90 2021-12-16 Buy
ChemScene CS-W020664 Kynurenic acid 99.03% 5g $270 2021-12-16 Buy
ChemScene CS-W020664 Kynurenic acid 99.03% 10g $540 2021-12-16 Buy
Crysdot CD11117095 Kynurenic acid 95+% 100mg $90 2021-12-16 Buy
CSNpharm CSN10840 Kynurenic acid 25mg $35 2021-12-16 Buy
DC Chemicals DC9889 Kynurenic acid >98% 100mg $180 2021-12-16 Buy
Sigma-Aldrich K3375 Kynurenic acid ≥98% 250mg $20.6 2024-03-01 Buy
Sigma-Aldrich K3375 Kynurenic acid ≥98% 1g $47.1 2024-03-01 Buy
Sigma-Aldrich 67667 Kynurenic acid analytical standard 10mg $75.3 2022-05-15 Buy

Properties

Melting point :275 °C (dec.)(lit.)
Boiling point :324.41°C (rough estimate)
Density :1.3175 (rough estimate)
refractive index :1.5400 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :DMSO : 9 mg/mL (47.58 mM; Need ultrasonic and warming)
form :Off-white to tan powder.
pka :1.08±0.30(Predicted)
color :White to Gray to Brown
Water Solubility :8.92g/L(100 ºC)
Merck :14,5327
BRN :147451
CAS DataBase Reference :492-27-3(CAS DataBase Reference)
EPA Substance Registry System :2-Quinolinecarboxylic acid, 4-hydroxy- (492-27-3)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

Kynurenic acid is a natural metabolite of tryptophan via the kynurenine pathway. It has pronounced effects on neuronal signaling and, thus, impacts diverse neurological systems. Kynurenic acid broadly antagonizes ionotopic glutamate receptors at high micromolar to millimolar concentrations and is used to pharmacologically block the activation of these receptors in vivo or in vitro. In addition, it reportedly has more potent effects at glutamate receptor subunit ζ-1 (Ki = 5.4 μM), GPR35 (EC50 = 39 μM), aryl hydrocarbon receptor (EC50 = 300 nM), and neuronal acetylcholine receptor α-7 (IC50 = 7 μM).

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