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ChemicalBook >> CAS DataBase List >> (±)-JQ1

(±)-JQ1

(±)-JQ1 price.
  • $85 - $1575
  • Product name: (±)-JQ1
  • CAS: 1268524-69-1
  • MF: C23H25ClN4O2S
  • MW: 456.99
  • EINECS:
  • MDL Number:MFCD23726614
  • Synonyms:[(R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-acetic acid tert-butyl ester;tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(+/-)-SGCBD01;rac JQ-1;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester;(+/-)-JQ1;tert-butyl 2-[7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11 ,12-tetraazatricyclo[8.3.0.0,2,6]trideca-2(6),4,7,10,1 2-pentaen-9-yl]acetate
8 prices
Selected condition：
Brand
  • AK Scientific
  • Alichem
  • Biosynth Carbosynth
  • Crysdot
  • Sigma-Aldrich
  • TRC
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product number3598DH
  • Product descriptionTert-butyl2-[7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate
  • Packaging50mg
  • Price$451
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number1268524691
  • Product descriptiontert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
  • Packaging100mg
  • Price$1575
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFJ74795
  • Product description(+/-)-JQ 1
  • Packaging10mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFJ74795
  • Product description(+/-)-JQ 1
  • Packaging50mg
  • Price$297.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11303096
  • Product descriptiontert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 95+%
  • Packaging100mg
  • Price$1500
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0974
  • Product description(+/-)-JQ1 ≥98% (HPLC)
  • Packaging5mg
  • Price$204
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0974
  • Product description(+/-)-JQ1 ≥98% (HPLC)
  • Packaging25mg
  • Price$324.8
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberT117575
  • Product descriptionrac-tert-Butyl2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
  • Packaging25mg
  • Price$605
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3598DH Tert-butyl2-[7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate 50mg $451 2021-12-16 Buy
Alichem 1268524691 tert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 100mg $1575 2021-12-16 Buy
Biosynth Carbosynth FJ74795 (+/-)-JQ 1 10mg $85 2021-12-16 Buy
Biosynth Carbosynth FJ74795 (+/-)-JQ 1 50mg $297.5 2021-12-16 Buy
Crysdot CD11303096 tert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 95+% 100mg $1500 2021-12-16 Buy
Sigma-Aldrich SML0974 (+/-)-JQ1 ≥98% (HPLC) 5mg $204 2024-03-01 Buy
Sigma-Aldrich SML0974 (+/-)-JQ1 ≥98% (HPLC) 25mg $324.8 2024-03-01 Buy
TRC T117575 rac-tert-Butyl2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 25mg $605 2021-12-16 Buy

Properties

Boiling point :610.4±65.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble2mg/mL, clear (warmed)
pka :2.05±0.60(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

(±) JQ1 (1268524-69-1) is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding by (±) JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers.1 Chiral version is available for purchase (Cat#10-1584).

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