JIB-04
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- $8 - $2723
- Product name: JIB-04
- CAS: 199596-05-9
- MF: C17H13ClN4
- MW: 308.76
- EINECS:-0
- MDL Number:MFCD26936344
- Synonyms:JIB-04;JIB-04 (NSC 693627);JIB04/JIB-04;5-Chloro-2(1H)-pyridinone (2E)-(phenyl-2-pyridinylmethylene)hydrazone;(E)-5-CHLORO-2-(2-(PHENYL(PYRIDIN-2-YL)METHYLENE)HYDRAZINYL)PYRIDINE;5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine;NSC 693627;5-Chloro-2(1H)-pyridinone (2E)-(phenyl-2-pyridinylmethylene)hydrazone JIB-04(NSC 693627)
35 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 50
- 1mg
- 10
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- 1000mg
- ManufacturerAK Scientific
- Product numberY1874
- Product descriptionJIB-04
- Packaging1g
- Price$2723
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA228395
- Product description(E)-5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine 98+%
- Packaging1g
- Price$336
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA228395
- Product description(E)-5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine 98+%
- Packaging250mg
- Price$134
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA228395
- Product description(E)-5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine 98+%
- Packaging100mg
- Price$83
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA228395
- Product description(E)-5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine 98+%
- Packaging50mg
- Price$56
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA228395
- Product description(E)-5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine 98+%
- Packaging25mg
- Price$38
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA228395
- Product description(E)-5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine 98+%
- Packaging10mg
- Price$23
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA228395
- Product description(E)-5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine 98+%
- Packaging5mg
- Price$16
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA228395
- Product description(E)-5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine 98+%
- Packaging1mg
- Price$8
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2160
- Product descriptionJIB04-NSC693627 99%
- Packaging50mg
- Price$352
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545940
- Product descriptionJIb-04 >98%
- Packaging5mg
- Price$173.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545940
- Product descriptionJIb-04 >98%
- Packaging25mg
- Price$406.3
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181264
- Product descriptionJIB-04 >98%
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181264
- Product descriptionJIB-04 >98%
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181264
- Product descriptionJIB-04 >98%
- Packaging1000mg
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15338
- Product descriptionJIB-04 ≥95%
- Packaging50mg
- Price$396
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | Y1874 | JIB-04 | 1g | $2723 | 2021-12-16 | Buy |
| Ambeed | A228395 | (E)-5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine 98+% | 1g | $336 | 2021-12-16 | Buy |
| Ambeed | A228395 | (E)-5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine 98+% | 250mg | $134 | 2021-12-16 | Buy |
| Ambeed | A228395 | (E)-5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine 98+% | 100mg | $83 | 2021-12-16 | Buy |
| Ambeed | A228395 | (E)-5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine 98+% | 50mg | $56 | 2021-12-16 | Buy |
| Ambeed | A228395 | (E)-5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine 98+% | 25mg | $38 | 2021-12-16 | Buy |
| Ambeed | A228395 | (E)-5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine 98+% | 10mg | $23 | 2021-12-16 | Buy |
| Ambeed | A228395 | (E)-5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine 98+% | 5mg | $16 | 2021-12-16 | Buy |
| Ambeed | A228395 | (E)-5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine 98+% | 1mg | $8 | 2021-12-16 | Buy |
| Axon Medchem | Axon2160 | JIB04-NSC693627 99% | 50mg | $352 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545940 | JIb-04 >98% | 5mg | $173.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545940 | JIb-04 >98% | 25mg | $406.3 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181264 | JIB-04 >98% | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181264 | JIB-04 >98% | 250mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181264 | JIB-04 >98% | 1000mg | $1802 | 2021-12-16 | Buy |
| Cayman Chemical | 15338 | JIB-04 ≥95% | 50mg | $396 | 2024-03-01 | Buy |
Properties
Boiling point :472.9±55.0 °C(Predicted)
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
pka :11.00±0.10(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey :YHHFKWKMXWRVTJ-OQKWZONESA-N
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
pka :11.00±0.10(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey :YHHFKWKMXWRVTJ-OQKWZONESA-N
Safety Information
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Description
JIB-04 is a pyridine hydrazone that broadly inhibits Jumonji histone demethylases (IC50s values = 230, 340, 435, 445, 855 and 1,100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3, and JMJD2C, respectively). It does not inhibit histone deacetylases and has minimal effect on the iron-containing enzymes methylcytosine dioxygenase TET1 and hypoxia-inducible factor prolyl hydroxylase 2. JIB-04 inhibits Jumonji demethylase activity, alters gene expression, and blocks viability of cancer cells but not in patient-matched normal cells. It also inhibits Jumonji demethylase activity in cancer cells in vivo, resulting in reduced tumor burden and prolonged survival.More related product prices
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