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ChemicalBook >> CAS DataBase List >> Ivabradine hydrochloride

Ivabradine hydrochloride

Ivabradine hydrochloride price.
  • $5 - $1802
  • Product name: Ivabradine hydrochloride
  • CAS: 148849-67-6
  • MF: C27H37ClN2O5
  • MW: 505.05
  • EINECS:638-798-3
  • MDL Number:MFCD00929899
  • Synonyms:Ivabradine hydrochloride;3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride;Ivabradine hydrochloride, >=99%;IVABRADINE HYDROCHLORIDE-OTHER COMPOUNDSCONTAINING AN UNFUSED PYRAZOLE RING(WHETHER OR NOT HYDROGENATED)IN THE STRUCTUR;3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one Hydrochloride;Corlentor;S-16257;(7,8-Dimethoxy 3-(3-(((1S)-(4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2H-benzazepin-2-one hydrochloride
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  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
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  • AvaChem
  • Biorbyt Ltd
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  • Cayman Chemical
  • Chemenu
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Package
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  • 5g
  • 10g
  • 1g
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product numberE147
  • Product descriptionIvabradineHCl
  • Packaging5mg
  • Price$29
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA103870
  • Product descriptionIvabradine hydrochloride 98+%
  • Packaging10mg
  • Price$5
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA103870
  • Product descriptionIvabradine hydrochloride 98+%
  • Packaging50mg
  • Price$9
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA103870
  • Product descriptionIvabradine hydrochloride 98+%
  • Packaging100mg
  • Price$16
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA103870
  • Product descriptionIvabradine hydrochloride 98+%
  • Packaging250mg
  • Price$29
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA103870
  • Product descriptionIvabradine hydrochloride 98+%
  • Packaging1g
  • Price$76
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA103870
  • Product descriptionIvabradine hydrochloride 98+%
  • Packaging5g
  • Price$279
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0000615
  • Product descriptionIVABRADINE HYDROCHLORIDE 95.00%
  • Packaging10MG
  • Price$133.35
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB1360
  • Product descriptionIvabradineHCl
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB1360
  • Product descriptionIvabradineHCl
  • Packaging10mg
  • Price$45
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS426912
  • Product descriptionIvabradine hydrochloride ≥98%
  • Packaging10mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS426912
  • Product descriptionIvabradine hydrochloride ≥98%
  • Packaging50mg
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS426912
  • Product descriptionIvabradine hydrochloride ≥98%
  • Packaging100mg
  • Price$16
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS426912
  • Product descriptionIvabradine hydrochloride ≥98%
  • Packaging250mg
  • Price$29
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS426912
  • Product descriptionIvabradine hydrochloride ≥98%
  • Packaging1g
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS426912
  • Product descriptionIvabradine hydrochloride ≥98%
  • Packaging5g
  • Price$276
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific E147 IvabradineHCl 5mg $29 2021-12-16 Buy
Ambeed A103870 Ivabradine hydrochloride 98+% 10mg $5 2021-12-16 Buy
Ambeed A103870 Ivabradine hydrochloride 98+% 50mg $9 2021-12-16 Buy
Ambeed A103870 Ivabradine hydrochloride 98+% 100mg $16 2021-12-16 Buy
Ambeed A103870 Ivabradine hydrochloride 98+% 250mg $29 2021-12-16 Buy
Ambeed A103870 Ivabradine hydrochloride 98+% 1g $76 2021-12-16 Buy
Ambeed A103870 Ivabradine hydrochloride 98+% 5g $279 2021-12-16 Buy
American Custom Chemicals Corporation API0000615 IVABRADINE HYDROCHLORIDE 95.00% 10MG $133.35 2021-12-16 Buy
ApexBio Technology B1360 IvabradineHCl 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology B1360 IvabradineHCl 10mg $45 2021-12-16 Buy
Arctom AS426912 Ivabradine hydrochloride ≥98% 10mg $5 2021-12-16 Buy
Arctom AS426912 Ivabradine hydrochloride ≥98% 50mg $9 2021-12-16 Buy
Arctom AS426912 Ivabradine hydrochloride ≥98% 100mg $16 2021-12-16 Buy
Arctom AS426912 Ivabradine hydrochloride ≥98% 250mg $29 2021-12-16 Buy
Arctom AS426912 Ivabradine hydrochloride ≥98% 1g $75 2021-12-16 Buy
Arctom AS426912 Ivabradine hydrochloride ≥98% 5g $276 2021-12-16 Buy

Properties

Melting point :193-196?C
alpha :58921 +7.8°; 36521 +27.8° (c = 1% in DMSO)
storage temp. :2-8°C
solubility :H2O: ≥5mg/mL (warmed)
form :powder
color :white to beige
optical activity :[α]/D +5 to +9°, c = 1 in DMSO
Merck :14,5247
InChIKey :HLUKNZUABFFNQS-ZMBIFBSDSA-N
SMILES :C([C@H]1CC2=CC(OC)=C(OC)C=C12)N(C)CCCN1CCC2=CC(OC)=C(OC)C=C2CC1=O.Cl |&1:1,r|
CAS DataBase Reference :148849-67-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.

Description

Ivabradine is a highly selective open channel blocker that targets the mixed Na+/K+ inward “funny current” (If) carried by hyperpolarization-activated cyclic nucleotide gated (HCN) channels. It suppresses channel activity at HCN1, HCN2, and HCN4, all with the same EC50 value of 4 μM. Notably, ivabradine selectively targets cardiac signaling, resulting in resting heart rate reducing (bradycardic) effects.

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