Cardiotonic Agent; Pacemaker Current (If) Inhibitor
Form:
HCl salt
REVIEW Ivabradine is a novel medication used for the symptomatic management of stable angina pectoris. Ivabradine selectively inhibits the pacemaker If current in a dose-dependent manner. Blocking this channel reduces cardiac pacemaker activity, slowing the heart rate and allowing more time for blood to flow to the myocardium.
REFERENCES
[1]
Sosunov EA, Anyukhovsky EP (2012). Differential effects of ivabradine and ryanodine on pacemaker activity in canine sinus node and purkinje fibers. J Cardiovasc Electrophysiol. 23(6):650-5. PMID 22353259.
[2]
Adile KK, Kapoor A, Jain SK, Gupta A, Kumar S, Tewari S, Garg N, Goel PK (2012). Safety and efficacy of oral ivabradine as a heart rate-reducing agent in patients undergoing CT coronary angiography. Br J Radiol. 85(1016):e424-8. PMID 22815422.
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