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ChemicalBook >> CAS DataBase List >> Entrectinib

Entrectinib

Entrectinib price.
  • $36 - $595
  • Product name: Entrectinib
  • CAS: 1108743-60-7
  • MF: C31H34F2N6O2
  • MW: 560.64
  • EINECS:
  • MDL Number:MFCD28129099
  • Synonyms:Entrectinib;Entrectinib(NMS-E628);N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;RXDX-101;Entrectinib,NMS-E628,RXDX-101;entrecitinib;Entrectinib(RXDX-101);NMS-E628
15 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Crysdot
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 100mg
  • 10mM(in 1mL DMSO)
  • 50mg
  • ManufacturerAK Scientific
  • Product number2923DC
  • Product descriptionEntrectinib
  • Packaging5mg
  • Price$232
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5859
  • Product descriptionEntrectinib
  • Packaging5mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5859
  • Product descriptionEntrectinib
  • Packaging10mM(in 1mL DMSO)
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5859
  • Product descriptionEntrectinib
  • Packaging25mg
  • Price$265
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5859
  • Product descriptionEntrectinib
  • Packaging100mg
  • Price$595
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19476
  • Product descriptionEntrectinib ≥98%
  • Packaging1mg
  • Price$36
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19476
  • Product descriptionEntrectinib ≥98%
  • Packaging5mg
  • Price$120
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19476
  • Product descriptionEntrectinib ≥98%
  • Packaging10mg
  • Price$223
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4343
  • Product descriptionEntrectinib 99.32%
  • Packaging100mg
  • Price$330
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4343
  • Product descriptionEntrectinib 99.32%
  • Packaging50mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4343
  • Product descriptionEntrectinib 99.32%
  • Packaging10mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4343
  • Product descriptionEntrectinib 99.32%
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004559
  • Product descriptionEntrectinib 98+%
  • Packaging25mg
  • Price$193
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004559
  • Product descriptionEntrectinib 98+%
  • Packaging50mg
  • Price$342
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004559
  • Product descriptionEntrectinib 98+%
  • Packaging100mg
  • Price$569
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2923DC Entrectinib 5mg $232 2021-12-16 Buy
ApexBio Technology B5859 Entrectinib 5mg $75 2021-12-16 Buy
ApexBio Technology B5859 Entrectinib 10mM(in 1mL DMSO) $130 2021-12-16 Buy
ApexBio Technology B5859 Entrectinib 25mg $265 2021-12-16 Buy
ApexBio Technology B5859 Entrectinib 100mg $595 2021-12-16 Buy
Cayman Chemical 19476 Entrectinib ≥98% 1mg $36 2024-03-01 Buy
Cayman Chemical 19476 Entrectinib ≥98% 5mg $120 2024-03-01 Buy
Cayman Chemical 19476 Entrectinib ≥98% 10mg $223 2024-03-01 Buy
ChemScene CS-4343 Entrectinib 99.32% 100mg $330 2021-12-16 Buy
ChemScene CS-4343 Entrectinib 99.32% 50mg $190 2021-12-16 Buy
ChemScene CS-4343 Entrectinib 99.32% 10mg $90 2021-12-16 Buy
ChemScene CS-4343 Entrectinib 99.32% 5mg $60 2021-12-16 Buy
Crysdot CD31004559 Entrectinib 98+% 25mg $193 2021-12-16 Buy
Crysdot CD31004559 Entrectinib 98+% 50mg $342 2021-12-16 Buy
Crysdot CD31004559 Entrectinib 98+% 100mg $569 2021-12-16 Buy

Properties

Boiling point :717.5±60.0 °C(Predicted)
Density :1.340±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥28.05 mg/mL in DMSO; insoluble in H2O; ≥9.82 mg/mL in EtOH with ultrasonic
form :solid
pka :12.01±0.43(Predicted)
color :Off-white to light yellow
InChIKey :HAYYBYPASCDWEQ-UHFFFAOYSA-N
SMILES :C(NC1C2=C(NN=1)C=CC(CC1=CC(F)=CC(F)=C1)=C2)(=O)C1=CC=C(N2CCN(C)CC2)C=C1NC1CCOCC1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Entrectinib is an inhibitor of TrkA (IC50 = 1.7 nM), TrkB (IC50 = 0.1 nM), and TrkC (IC50 = 0.1 nM), as well as C-ros oncogene 1 (ROS1; IC50 = 0.2 nM) and anaplastic lymphoma kinase (ALK; IC50 = 1.6 nM). Entrectinib blocks proliferation of ALK-dependent cell lines, including those with L1196M or C1156Y resistance mutations, and inhibits ALK‐dependent signaling. It has been shown to inhibit the growth of a non-small cell lung cancer cell line bearing an EML4-ALK rearrangement. In mice bearing various Trk, ROS1, or ALK-driven xenografts, entrectinib has been shown to induce tumor regression.

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