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ChemicalBook >> CAS DataBase List >> EAI-045

EAI-045

EAI-045 price.
  • $7 - $1575
  • Product name: EAI-045
  • CAS: 1942114-09-1
  • MF: C19H14FN3O3S
  • MW: 383.4
  • EINECS:-0
  • MDL Number:MFCD30187871
  • Synonyms:EAI-045;2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide;EA1045;α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-N-2-thiazolyl-2H-Isoindole-2-acetamide;EAI 045;EAI-045;CS-2350;EAI045;EAI 045;EAI-045;N-(3-((5-fluoroethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide (EAI-045)
28 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • AvaChem
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Medical Isotopes, Inc.
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 5g
  • ManufacturerAK Scientific
  • Product number5125EG
  • Product descriptionCID121231412
  • Packaging10mg
  • Price$185
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105328
  • Product description2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97%
  • Packaging5mg
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105328
  • Product description2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97%
  • Packaging10mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105328
  • Product description2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97%
  • Packaging25mg
  • Price$14
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105328
  • Product description2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97%
  • Packaging50mg
  • Price$20
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105328
  • Product description2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97%
  • Packaging100mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105328
  • Product description2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97%
  • Packaging250mg
  • Price$44
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105328
  • Product description2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97%
  • Packaging1g
  • Price$109
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105328
  • Product description2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97%
  • Packaging5g
  • Price$376
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004748
  • Product descriptionALPHA-(5-FLUORO-2-HYDROXYPHENYL)-1,3-DIHYDRO-1-OXO-N-2-THIAZOLYL-2H-ISOINDOLE-2-ACETAMIDE 95.00%
  • Packaging5MG
  • Price$505.05
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6054
  • Product descriptionEAI045
  • Packaging10mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6054
  • Product descriptionEAI045
  • Packaging25mg
  • Price$330
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6054
  • Product descriptionEAI045
  • Packaging100mg
  • Price$980
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3368
  • Product descriptionEAI450
  • Packaging5mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3368
  • Product descriptionEAI450
  • Packaging25mg
  • Price$275
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3368
  • Product descriptionEAI450
  • Packaging100mg
  • Price$575
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5125EG CID121231412 10mg $185 2021-12-16 Buy
Ambeed A105328 2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97% 5mg $7 2021-12-16 Buy
Ambeed A105328 2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97% 10mg $10 2021-12-16 Buy
Ambeed A105328 2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97% 25mg $14 2021-12-16 Buy
Ambeed A105328 2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97% 50mg $20 2021-12-16 Buy
Ambeed A105328 2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97% 100mg $30 2021-12-16 Buy
Ambeed A105328 2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97% 250mg $44 2021-12-16 Buy
Ambeed A105328 2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97% 1g $109 2021-12-16 Buy
Ambeed A105328 2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97% 5g $376 2021-12-16 Buy
American Custom Chemicals Corporation INB0004748 ALPHA-(5-FLUORO-2-HYDROXYPHENYL)-1,3-DIHYDRO-1-OXO-N-2-THIAZOLYL-2H-ISOINDOLE-2-ACETAMIDE 95.00% 5MG $505.05 2021-12-16 Buy
ApexBio Technology B6054 EAI045 10mg $200 2021-12-16 Buy
ApexBio Technology B6054 EAI045 25mg $330 2021-12-16 Buy
ApexBio Technology B6054 EAI045 100mg $980 2021-12-16 Buy
AvaChem 3368 EAI450 5mg $105 2021-12-16 Buy
AvaChem 3368 EAI450 25mg $275 2021-12-16 Buy
AvaChem 3368 EAI450 100mg $575 2021-12-16 Buy

Properties

Density :1.546±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :≥38.3 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :7.20±0.50(Predicted)
color :White to khaki

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

EAI045 is a potent and selective EGFR inhibitor (fourth generation). EAI045 targets selected drug-resistant EGFR mutants without affecting the wild-type receptor. EAI045 inhibits L858R/T790M-mutant EGFR with low-nanomolar potency in biochemical assays. Therefore, it is a potential candidate drug for the treatment of related non-small cell lung cancer (NSCLC). It should be noted that EAI-045 is effectively in targeting the EGFR C797S mutation, which is resistance to the third-generation EGFR inhibitors including AZD9291 (osimertinib) and CO-1686 (rociletinib).

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