Dronedarone
- $50 - $4232.5
- Product name: Dronedarone
- CAS: 141626-36-0
- MF: C31H44N2O5S
- MW: 556.76
- EINECS:
- MDL Number:MFCD00910331
- Synonyms:Dronedarone;N-(2-Butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamide;N-(2-butyl-3-(4-(3-(dibutylaMino)propoxy)benzoyl)benzofuran-5-yl)MethanesulfonaMide;MethanesulfonaMide,N-[2-butyl-3-[4-[3-(dibutylaMino)propoxy]benzoyl]-5-benzofuranyl]-;CS-294;Dronedarone (SR-33589);N-[2-butyl-3-[[4-[3-(dibutylamino)propoxy]phenyl]-oxomethyl]-5-benzofuranyl]methanesulfonamide;DRONEDARONE BASE
19 prices
Selected condition:
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Chemenu
- ChemScene
- Chemtos
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
Package
- 10mM(in 1mL DMSO)
- 5mg
- 10mg
- 20mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1G
- 5G
- ManufacturerAK Scientific
- Product numberW3084
- Product descriptionDronedarone
- Packaging25mg
- Price$111
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA404830
- Product descriptionDronedarone 98+%
- Packaging10mg
- Price$53
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA404830
- Product descriptionDronedarone 98+%
- Packaging25mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA404830
- Product descriptionDronedarone 98+%
- Packaging50mg
- Price$116
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0024392
- Product descriptionDRONEDARONE 95.00%
- Packaging5G
- Price$4232.5
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0024392
- Product descriptionDRONEDARONE 95.00%
- Packaging1G
- Price$730.8
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3374
- Product descriptionDronedarone
- Packaging10mM(in 1mL DMSO)
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3374
- Product descriptionDronedarone
- Packaging1g
- Price$357
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3374
- Product descriptionDronedarone
- Packaging5g
- Price$973
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN90014
- Product descriptionDronedarone
- Packaging20mg
- Price$218
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611660
- Product descriptionDronedarone
- Packaging100mg
- Price$397.8
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611660
- Product descriptionDronedarone
- Packaging250mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM158968
- Product descriptionN-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide 98%
- Packaging50mg
- Price$299
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0384
- Product descriptionDronedarone 99.81%
- Packaging10mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0384
- Product descriptionDronedarone 99.81%
- Packaging50mg
- Price$186
- Updated2021-12-16
- Buy
- ManufacturerChemtos
- Product numberD-2591
- Product descriptionDronedaroneHydrochlorideLabeledd7
- Packaging10mg
- Price$2750
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | W3084 | Dronedarone | 25mg | $111 | 2021-12-16 | Buy |
Ambeed | A404830 | Dronedarone 98+% | 10mg | $53 | 2021-12-16 | Buy |
Ambeed | A404830 | Dronedarone 98+% | 25mg | $90 | 2021-12-16 | Buy |
Ambeed | A404830 | Dronedarone 98+% | 50mg | $116 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0024392 | DRONEDARONE 95.00% | 5G | $4232.5 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0024392 | DRONEDARONE 95.00% | 1G | $730.8 | 2021-12-16 | Buy |
ApexBio Technology | A3374 | Dronedarone | 10mM(in 1mL DMSO) | $50 | 2021-12-16 | Buy |
ApexBio Technology | A3374 | Dronedarone | 1g | $357 | 2021-12-16 | Buy |
ApexBio Technology | A3374 | Dronedarone | 5g | $973 | 2021-12-16 | Buy |
Arctom | CFN90014 | Dronedarone | 20mg | $218 | 2021-12-16 | Buy |
Biorbyt Ltd | orb611660 | Dronedarone | 100mg | $397.8 | 2021-12-16 | Buy |
Biorbyt Ltd | orb611660 | Dronedarone | 250mg | $606.9 | 2021-12-16 | Buy |
Chemenu | CM158968 | N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide 98% | 50mg | $299 | 2021-12-16 | Buy |
ChemScene | CS-0384 | Dronedarone 99.81% | 10mg | $60 | 2021-12-16 | Buy |
ChemScene | CS-0384 | Dronedarone 99.81% | 50mg | $186 | 2021-12-16 | Buy |
Chemtos | D-2591 | DronedaroneHydrochlorideLabeledd7 | 10mg | $2750 | 2021-12-16 | Buy |
Properties
Melting point :65.3°
Boiling point :683.9±65.0 °C(Predicted)
Density :1.143±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :≥27.84 mg/mL in DMSO; insoluble in H2O; ≥49.8 mg/mL in EtOH
form :solid
pka :7.40±0.30(Predicted)
color :White to off-white
CAS DataBase Reference :141626-36-0(CAS DataBase Reference)
Boiling point :683.9±65.0 °C(Predicted)
Density :1.143±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :≥27.84 mg/mL in DMSO; insoluble in H2O; ≥49.8 mg/mL in EtOH
form :solid
pka :7.40±0.30(Predicted)
color :White to off-white
CAS DataBase Reference :141626-36-0(CAS DataBase Reference)
Safety Information
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Signal word: | Warning | ||||||||||||||||||||||||||||||||||||||||||
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Precautionary statements: |
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Description
AF is the most common form of sustained cardiac arrhythmia, with an increasing prevalence in the aging population. AF accounts for 34.5% of arrhythmia-related hospital admissions in the United States. The most significant consequences of AF include congestive heart failure, a 5-fold increased risk of stroke, and increased rate of mortality. Although a 90% conversion rate from AF to normal sinus rhythm (NSR) can be achieved with electrical cardioversion, up to 70% of these patients require additional therapy with antiarrhythmic drugs in order to maintain NSR.Dronedarone, a close analog of amiodarone, is structurally modified to provide improved safety and pharmacokinetic profile. With the introduction of a sulfonamide group, dronedarone is less lipophilic, has lower tissue accumulation, and has a much shorter serum half-life (~24 h) compared with amiodarone. Additionally, dronedarone lacks the iodine moieties that are responsible for thyroid dysfunctions associated with amiodarone. Dronedarone is specifically indicated to reduce the risk of cardiovascular hospitalization in patients with paroxysmal or persistent AF or AFL, with a recent episode of AF/AFL and associated cardiovascular risk factors, who are in sinus rhythm or who will be cardioverted. Similar to amiodarone, dronedarone is a potent blocker of multiple ion currents (including the rapidly activating delayed-rectifier potassium current, the slowly activating delayed-rectifier potassium current, the inward rectifier potassium current, the acetylcholine-activated potassium current, peak sodium current, and L-type calcium current) and exhibits antiadrenergic effects. Overall, dronedarone was well tolerated. The most common side effects were gastrointestinal in nature and included nausea, vomiting, and diarrhea.
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