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ChemicalBook >> CAS DataBase List >> Dapagliflozin

Dapagliflozin

Dapagliflozin price.
  • $5 - $1504.5
  • Product name: Dapagliflozin
  • CAS: 461432-26-8
  • MF: C21H25ClO6
  • MW: 408.88
  • EINECS:639-683-0
  • MDL Number:MFCD13182359
  • Synonyms:Dapagliflozin(BMS-512148);1-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-1-deoxy-beta-D-glucopyranose (1S)-1,5-Anhydro-1-C-[4-chloro-3-(4-ethoxybenzyl)phenyl]-D-glucitol (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxyMethyl)tetrahydro-2H-pyran-3,4,5-triol;(2S,3R,4R,5S,6R)-2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxyMethyltetrahydro-2H-pyran-3,4,5-triol;1-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-1-deoxy-beta-D-glucopyranose;BMS5121458;Dag coluMn net;Dapagliflozin Isomer Impurity;Dapagliflozin, >=98%
46 prices
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Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • TRC
  • Usbiological
Package
  • 1unit
  • 10mM(in 1mL DMSO)
  • 1mg
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  • 10mg
  • 20mg
  • 25mg
  • 50mg
  • 100mg
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  • 1g
  • 2g
  • 5g
  • 10g
  • 25g
  • ManufacturerAK Scientific
  • Product numberJ95139
  • Product descriptionDapagliflozin
  • Packaging1g
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ95139
  • Product descriptionDapagliflozin
  • Packaging10g
  • Price$380
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA120381
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+%
  • Packaging5mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA120381
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+%
  • Packaging10mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA120381
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+%
  • Packaging50mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA120381
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+%
  • Packaging100mg
  • Price$17
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA120381
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+%
  • Packaging250mg
  • Price$32
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA120381
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+%
  • Packaging1g
  • Price$81
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA120381
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+%
  • Packaging5g
  • Price$237
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA120381
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+%
  • Packaging10g
  • Price$447
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA120381
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+%
  • Packaging25g
  • Price$878
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5854
  • Product descriptionDapagliflozin
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5854
  • Product descriptionDapagliflozin
  • Packaging5mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5854
  • Product descriptionDapagliflozin
  • Packaging10mM(in 1mL DMSO)
  • Price$77
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5854
  • Product descriptionDapagliflozin
  • Packaging25mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5854
  • Product descriptionDapagliflozin
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J95139 Dapagliflozin 1g $70 2021-12-16 Buy
AK Scientific J95139 Dapagliflozin 10g $380 2021-12-16 Buy
Ambeed A120381 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+% 5mg $5 2021-12-16 Buy
Ambeed A120381 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+% 10mg $6 2021-12-16 Buy
Ambeed A120381 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+% 50mg $10 2021-12-16 Buy
Ambeed A120381 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+% 100mg $17 2021-12-16 Buy
Ambeed A120381 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+% 250mg $32 2021-12-16 Buy
Ambeed A120381 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+% 1g $81 2021-12-16 Buy
Ambeed A120381 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+% 5g $237 2021-12-16 Buy
Ambeed A120381 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+% 10g $447 2021-12-16 Buy
Ambeed A120381 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+% 25g $878 2021-12-16 Buy
ApexBio Technology A5854 Dapagliflozin 1unit $28 2021-12-16 Buy
ApexBio Technology A5854 Dapagliflozin 5mg $70 2021-12-16 Buy
ApexBio Technology A5854 Dapagliflozin 10mM(in 1mL DMSO) $77 2021-12-16 Buy
ApexBio Technology A5854 Dapagliflozin 25mg $210 2021-12-16 Buy
ApexBio Technology A5854 Dapagliflozin 100mg $450 2021-12-16 Buy

Properties

Melting point :55-58°C
Boiling point :609.0±55.0 °C(Predicted)
Density :1.349
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :13.23±0.70(Predicted)
form :Solid
color :White to Pale Yellow
Stability :Hygroscopic
InChIKey :JVHXJTBJCFBINQ-JNTNYNDRNA-N
SMILES :O[C@@H]1[C@H]([C@H](O)[C@@H](CO)O[C@H]1C1C=CC(Cl)=C(CC2C=CC(OCC)=CC=2)C=1)O |&1:1,2,3,5,9,r|

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P314 Get medical advice/attention if you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

Inhibiting renal glucose reabsorbtion through the sodium-glucose cotransporter (SGLT) offers an insulin-independent alternative to controlling blood glucose concentrations in patients with type 2 diabetes. While the majority of glucose is reabsorbed from glomerular filtrate by SGLT2, which is predominantly expressed in the kidney S1 segment of the proximal tubule, SGLT1 reabsorbs glucose in the distal S3 segment of the renal proximal tubule as well as from the small intestine. Dapagliflozin is a first generation, selective SGLT inhibitor that blocks glucose transport with about 100-fold selectivity for SGLT2 (Ki = 6 nM; EC50 = 1.1 nM) over SGLT1 (Ki = 390 nM). After single oral doses ranging from 0.1 to 1.0 mg/kg, dapagliflozin increases urinary glucose excretion in both normal and diabetic rats, improves glucose tolerance in normal rats, and reduces hyperglycemia in Zucker diabetic fatty rats. Within two weeks of treating diabetic rats with 0.1 to 1.0 mg/kg dapagliflozin, fasting and fed glucose levels have been shown to be significantly lowered as a result of increased glucose utilization accompanied by reduced glucose production.

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