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ChemicalBook >> CAS DataBase List >> Chk2 Inhibitor

Chk2 Inhibitor

Chk2 Inhibitor price.
  • $242 - $645
  • Product name: Chk2 Inhibitor
  • CAS: 724708-21-8
  • MF: C15H13N5O2
  • MW: 295.3
  • EINECS:-0
  • MDL Number:MFCD22380609
  • Synonyms:Chk2 Inhibitor;Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem;Azepino[3,4-b]indol-1(2H)-one, 5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro-, (5Z)-;SC 203885;SC203885;SC-203885
3 prices
Selected condition：
Brand
  • Cayman Chemical
  • TRC
Package
  • 500μg
  • 1000μg
  • 1mg
  • ManufacturerCayman Chemical
  • Product number21184
  • Product descriptionChk2 Inhibitor
  • Packaging500μg
  • Price$242
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21184
  • Product descriptionChk2 Inhibitor
  • Packaging1mg
  • Price$387
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberC263468
  • Product descriptionChk2Inhibitor
  • Packaging1000μg
  • Price$645
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 21184 Chk2 Inhibitor 500μg $242 2024-03-01 Buy
Cayman Chemical 21184 Chk2 Inhibitor 1mg $387 2024-03-01 Buy
TRC C263468 Chk2Inhibitor 1000μg $645 2021-12-16 Buy

Properties

storage temp. :-20C
solubility :DMSO: Soluble
form :Pale yellow solid

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Chk2 Inhibitor is an indoloazepine checkpoint kinase inhibitor that mediates apoptosis and cell cycle arrest. Checkpoint kinase 2 is activated upon DNA damage or genomic instability which eventually causes apoptosis. Mechanistic studies show that Chk2 inhibitor causes autophosphorylation of Chk2 at Thr68 and targets ATP binding pockets of Chk2. Further studies demonstrate that Chk2 inhibitors also inhibit Chk1 and MEK-1 and affect interleukin-2 (IL-2), TNF-α, MEK-1, and GSK-3β.