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ChemicalBook >> CAS DataBase List >> PD 173074

PD 173074

PD 173074 price.
  • $28 - $1647
  • Product name: PD 173074
  • CAS: 219580-11-7
  • MF: C28H41N7O3
  • MW: 523.67
  • EINECS:
  • MDL Number:MFCD08705327
  • Synonyms:n-[2-[[4-(diethylamino)butyl]amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-n'-(1,1-dimethylethyl)urea;N-[2-[[4-(diethylaMino)butyl]aMino]-6-(3,5-diMethoxyphenyl)pyrido[2,3-d ]pyriMidin-7-yl]-N'-(1,1-diMethylethyl)-;PD173074/PD-173074;1-(tert-butyl)-3-(2-((4-(diethylaMino)butyl)aMino)-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl)urea;1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-;Urea, N-[2-[[4-(diethylaMino)butyl]aMino]-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl]-N'-(1,1-diMethylethyl)-;PD176074;N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea PD 173074
38 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Labseeker
  • Matrix Scientific
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
Package
  • 1MG
  • 1unit
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 10mM(in 1mL DMSO)
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberX7486
  • Product descriptionPD 173074
  • Packaging1g
  • Price$1491
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150425
  • Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
  • Packaging5mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150425
  • Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
  • Packaging10mg
  • Price$58
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150425
  • Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
  • Packaging50mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150425
  • Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
  • Packaging100mg
  • Price$136
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150425
  • Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
  • Packaging250mg
  • Price$262
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150425
  • Product description1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+%
  • Packaging1g
  • Price$650
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000180
  • Product descriptionPD 173074 95.00%
  • Packaging1MG
  • Price$166.95
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000180
  • Product descriptionPD 173074 95.00%
  • Packaging10MG
  • Price$693.92
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8253
  • Product descriptionPD 173074
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8253
  • Product descriptionPD 173074
  • Packaging10mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8253
  • Product descriptionPD 173074
  • Packaging10mM(in 1mL DMSO)
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8253
  • Product descriptionPD 173074
  • Packaging50mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60135
  • Product descriptionPD 173074
  • Packaging10mg
  • Price$118
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13032
  • Product descriptionPD 173074 ≥98%
  • Packaging5mg
  • Price$39
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13032
  • Product descriptionPD 173074 ≥98%
  • Packaging10mg
  • Price$74
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7486 PD 173074 1g $1491 2021-12-16 Buy
Ambeed A150425 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% 5mg $45 2021-12-16 Buy
Ambeed A150425 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% 10mg $58 2021-12-16 Buy
Ambeed A150425 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% 50mg $105 2021-12-16 Buy
Ambeed A150425 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% 100mg $136 2021-12-16 Buy
Ambeed A150425 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% 250mg $262 2021-12-16 Buy
Ambeed A150425 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea 99+% 1g $650 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000180 PD 173074 95.00% 1MG $166.95 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000180 PD 173074 95.00% 10MG $693.92 2021-12-16 Buy
ApexBio Technology A8253 PD 173074 1unit $28 2021-12-16 Buy
ApexBio Technology A8253 PD 173074 10mg $50 2021-12-16 Buy
ApexBio Technology A8253 PD 173074 10mM(in 1mL DMSO) $60 2021-12-16 Buy
ApexBio Technology A8253 PD 173074 50mg $140 2021-12-16 Buy
Arctom CFN60135 PD 173074 10mg $118 2021-12-16 Buy
Cayman Chemical 13032 PD 173074 ≥98% 5mg $39 2024-03-01 Buy
Cayman Chemical 13032 PD 173074 ≥98% 10mg $74 2024-03-01 Buy

Properties

Melting point :82-85°C
Density :1.163
storage temp. :2-8°C
solubility :DMSO: 21 mg/mL
form :solid
pka :10.12±0.43(Predicted)
color :yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

The fibroblast growth factor receptors (FGFRs) are cell surface receptors with intrinsic tyrosine kinase activity, which is necessary for receptor activation and signal propagation. PD 173074 is a potent and selective inhibitor of FGFR tyrosine kinase activity, blocking autophosphorylation of FGFR1 with an IC50 value of 21.5 nM. For comparison, it weakly inhibits PDGFR and c-Src (IC50 = 17.6 and 19.8 μM, respectively) and has no effect on EGFR, InsR, MEK, or PKC. PD 173074 also prevents signaling, at nanomolar levels, through FGFR2-5. Inhibition of FGFR signaling using PD 173074, impairs angiogenesis as well as self-renewal of stem cells via ERK1/2 activation.

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