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ChemicalBook >> CAS DataBase List >> Ceritinib (LDK378)

Ceritinib (LDK378)

Ceritinib (LDK378) price.
  • $25 - $3600
  • Product name: Ceritinib (LDK378)
  • CAS: 1032900-25-6
  • MF: C28H36ClN5O3S
  • MW: 558.14
  • EINECS:811-457-8
  • MDL Number:MFCD26142648
  • Synonyms:Eritinib;5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)p;Ceritinib (LDK378);LDK 378 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine;Eritinib (LDK378);Ceritinib, >=98%;LDK37;CS-819
45 prices
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  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
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  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1199-M100
  • Product descriptionLDK378 ≥95%
  • Packaging100mg
  • Price$702
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2510AH
  • Product descriptionLDK378
  • Packaging5mg
  • Price$67
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126440
  • Product description5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 98+%
  • Packaging5mg
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126440
  • Product description5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 98+%
  • Packaging10mg
  • Price$43
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126440
  • Product description5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 98+%
  • Packaging100mg
  • Price$68
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126440
  • Product description5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 98+%
  • Packaging250mg
  • Price$102
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126440
  • Product description5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 98+%
  • Packaging1g
  • Price$810
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA126440
  • Product description5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 98+%
  • Packaging5g
  • Price$810
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8328
  • Product descriptionLDK378
  • Packaging10mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8328
  • Product descriptionLDK378
  • Packaging200mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60073
  • Product descriptionCeritinib(LDK378)
  • Packaging20mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3373
  • Product descriptionCeritinib
  • Packaging5mg
  • Price$29
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3373
  • Product descriptionCeritinib
  • Packaging25mg
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3373
  • Product descriptionCeritinib
  • Packaging100mg
  • Price$149
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3373
  • Product descriptionCeritinib
  • Packaging1g
  • Price$290
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146278
  • Product descriptionCeritinib(LDK378) >99%
  • Packaging100mg
  • Price$414.8
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1199-M100 LDK378 ≥95% 100mg $702 2021-12-16 Buy
AK Scientific 2510AH LDK378 5mg $67 2021-12-16 Buy
Ambeed A126440 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 98+% 5mg $25 2021-12-16 Buy
Ambeed A126440 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 98+% 10mg $43 2021-12-16 Buy
Ambeed A126440 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 98+% 100mg $68 2021-12-16 Buy
Ambeed A126440 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 98+% 250mg $102 2021-12-16 Buy
Ambeed A126440 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 98+% 1g $810 2021-12-16 Buy
Ambeed A126440 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 98+% 5g $810 2021-12-16 Buy
ApexBio Technology A8328 LDK378 10mg $70 2021-12-16 Buy
ApexBio Technology A8328 LDK378 200mg $300 2021-12-16 Buy
Arctom CFN60073 Ceritinib(LDK378) 20mg $50 2021-12-16 Buy
AvaChem 3373 Ceritinib 5mg $29 2021-12-16 Buy
AvaChem 3373 Ceritinib 25mg $49 2021-12-16 Buy
AvaChem 3373 Ceritinib 100mg $149 2021-12-16 Buy
AvaChem 3373 Ceritinib 1g $290 2021-12-16 Buy
Biorbyt Ltd orb146278 Ceritinib(LDK378) >99% 100mg $414.8 2021-12-16 Buy

Properties

Melting point :173-175°C
Boiling point :720.7±70.0 °C(Predicted)
Density :1.251±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :10.16±0.10(Predicted)
form :Off-white solid.
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Ceritinib (previously LDK378l, brand name Zykadia; Novartis Pharmaceuticals) is an oral small molecule tyrosine kinase inhibitor of ALK [87]. Preclinical studies suggested that it would inhibit ROS1 as well [88, 89].

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