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ChemicalBook >> CAS DataBase List >> Carbamazepine

Carbamazepine

Carbamazepine price.
  • $7 - $2055.9
  • Product name: Carbamazepine
  • CAS: 298-46-4
  • MF: C15H12N2O
  • MW: 236.27
  • EINECS:206-062-7
  • MDL Number:MFCD00005073
  • Synonyms:CarbaMazepine (D10, 98%);CarbaMazepine-13C6;Carbamazepine solution ;CARBAMAZEPINE;ANBROMINE;5H-DIBENZ[B,F]AZEPINE-5-CARBOXAMIDE;5-Carbamoyl-5H-dibenzo(b,f)azepine;5-Carbamoyldibenzo(b,f)azepine
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  • AHH
  • AK Scientific
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  • ApexBio Technology
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  • Chem-Impex
  • ChemScene
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  • 25mg
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  • 1mL
  • 1G
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  • 250g
  • 10mM(in 1mL DMSO)
  • ManufacturerAHH
  • Product numberMT-48928
  • Product descriptionCarbamazepine 98%
  • Packaging250g
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ10617
  • Product descriptionCarbamazepine
  • Packaging25mg
  • Price$29
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ62590
  • Product descriptionCarbamazepine, 98%
  • Packaging25g
  • Price$129
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ62590
  • Product descriptionCarbamazepine, 98%
  • Packaging100g
  • Price$388
  • Updated2024-03-01
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0001842
  • Product descriptionCARBAMAZEPINE 95.00%
  • Packaging1G
  • Price$129.15
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0001842
  • Product descriptionCARBAMAZEPINE 95.00%
  • Packaging10G
  • Price$2055.9
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1390
  • Product descriptionCarbamazepine
  • Packaging50mg
  • Price$42
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1390
  • Product descriptionCarbamazepine
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBIC0130
  • Product descriptionCarbamazepine
  • Packaging25g
  • Price$66
  • Updated2021-12-16
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  • ManufacturerApolloscientific
  • Product numberBIC0130
  • Product descriptionCarbamazepine
  • Packaging100g
  • Price$196
  • Updated2021-12-16
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  • ManufacturerApolloscientific
  • Product numberBIC0130
  • Product descriptionCarbamazepine
  • Packaging250g
  • Price$392
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS019070
  • Product descriptionCarbamazepine ≥98%
  • Packaging1g
  • Price$7
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS019070
  • Product descriptionCarbamazepine ≥98%
  • Packaging5g
  • Price$12
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS019070
  • Product descriptionCarbamazepine ≥98%
  • Packaging10g
  • Price$15
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS019070
  • Product descriptionCarbamazepine ≥98%
  • Packaging25g
  • Price$33
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS019070
  • Product descriptionCarbamazepine ≥98%
  • Packaging100g
  • Price$88
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH MT-48928 Carbamazepine 98% 250g $320 2021-12-16 Buy
AK Scientific J10617 Carbamazepine 25mg $29 2021-12-16 Buy
Alfa Aesar J62590 Carbamazepine, 98% 25g $129 2024-03-01 Buy
Alfa Aesar J62590 Carbamazepine, 98% 100g $388 2024-03-01 Buy
American Custom Chemicals Corporation API0001842 CARBAMAZEPINE 95.00% 1G $129.15 2021-12-16 Buy
American Custom Chemicals Corporation API0001842 CARBAMAZEPINE 95.00% 10G $2055.9 2021-12-16 Buy
ApexBio Technology B1390 Carbamazepine 50mg $42 2021-12-16 Buy
ApexBio Technology B1390 Carbamazepine 10mM(in 1mL DMSO) $50 2021-12-16 Buy
Apolloscientific BIC0130 Carbamazepine 25g $66 2021-12-16 Buy
Apolloscientific BIC0130 Carbamazepine 100g $196 2021-12-16 Buy
Apolloscientific BIC0130 Carbamazepine 250g $392 2021-12-16 Buy
Arctom AS019070 Carbamazepine ≥98% 1g $7 2021-12-16 Buy
Arctom AS019070 Carbamazepine ≥98% 5g $12 2021-12-16 Buy
Arctom AS019070 Carbamazepine ≥98% 10g $15 2021-12-16 Buy
Arctom AS019070 Carbamazepine ≥98% 25g $33 2021-12-16 Buy
Arctom AS019070 Carbamazepine ≥98% 100g $88 2021-12-16 Buy

Properties

Melting point :191-192 °C (lit.)
Boiling point :378.73°C (rough estimate)
Density :1.1099 (rough estimate)
refractive index :1.5906 (estimate)
Flash point :9℃
storage temp. :2-8°C
solubility :45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble29mg/mL
pka :13.94±0.20(Predicted)
form :Crystals
color :Almost white
Water Solubility :pract. insoluble
Merck :14,1781
BCS Class :2
LogP :2.450
CAS DataBase Reference :298-46-4(CAS DataBase Reference)
NIST Chemistry Reference :Carbamazepine(298-46-4)
EPA Substance Registry System :5H-Dibenz[b,f]azepine-5-carboxamide (298-46-4)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
Precautionary statements:
P201 Obtain special instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Carbamazepine (CBZ) is a first generation anticonvulsant and mood stabilizing compound that has been used as a therapeutic in the context of neuropathic pain, epilepsy, and affective disorders. It exerts its effects by blocking voltage-gated sodium channels (IC50 = 640 μM), making fewer of these channels available to subsequently open, which leads to decreased high-frequency repetitive firing of action potentials. The estimated IC50 values for inhibition of Nav1.7-, Nav1.3-, and Nav1.8-type channels by CBZ following prolonged inactivation have been reported as 406, 900, and 138 μM, respectively. CBZ can also inhibit L-type Ca2+ channels (IC50 = 974 μM) and has been shown to potentiate GABAA receptors (IC50 >3 mM).

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