CFTRinh-172
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- $70 - $809
- Product name: CFTRinh-172
- CAS: 307510-92-5
- MF: C18H10F3NO3S2
- MW: 409.4
- EINECS:
- MDL Number:MFCD06411408
- Synonyms:3-[(3-Trifluoromethyl)Phenyl]-5-[(4-Carboxyphenyl)Methylene]-2-Thioxo-4-Thiazolidinone 4-[(Z)-[4-Oxo-2-Sulfanylidene-3-[3-(Trifluoromethyl)Phenyl]-1,3-Thiazolidin-5-Ylidene]Methyl]Benzoic Acid;4-[[4-Oxo-2-Thioxo-3-[3-(Trifluoromethyl)Phenyl]Thiazolidin-;InSolution? CFTR Inhibitor-172 ;CFTR(INH)-172;CFTR INHIBITOR-172;5-[(4-CARBOXYPHENYL)METHYLENE]-2-THIOXO-3-[(3-TRIFLUOROMETHYL)PHENYL-4-THIAZOLIDINONE];3-[(3-TRIFLUOROMETHYL)PHENYL]-5-[(4-CARBOXYPHENYL)METHYLENE]-2-THIOXO-4-THIAZOLIDINONE;4-[4-OXO-2-THIOXO-3-(3TRIFLUOROMETHYL-PHENYL)-THIAZOLIDIN-5-YLIDENEMETHYL]-BENZOIC ACID (FOR R&D ONLY)
28 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10mg
- 10
- 5mg
- 25mg
- 100mg
- 500MG
- 50mg
- 50
- 10mM(in 1mL DMSO)
- 1g
- ManufacturerAK Scientific
- Product number2313AH
- Product description4-[(E)-[4-oxo-2-Sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoicacid
- Packaging1g
- Price$771
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberHCH0012817
- Product description4-[4-OXO-2-THIOXO-3-(3-TRIFLUOROMETHYL-PHENYL)-THIAZOLIDIN-(5Z)-YLIDENEMETHYL]-BENZOIC ACID 95.00%
- Packaging500MG
- Price$589
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberHCH0012817
- Product description4-[4-OXO-2-THIOXO-3-(3-TRIFLUOROMETHYL-PHENYL)-THIAZOLIDIN-(5Z)-YLIDENEMETHYL]-BENZOIC ACID 95.00%
- Packaging1G
- Price$778
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1435
- Product descriptionCFTRinh-172
- Packaging10mM(in 1mL DMSO)
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1435
- Product descriptionCFTRinh-172
- Packaging10mg
- Price$103
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1435
- Product descriptionCFTRinh-172
- Packaging50mg
- Price$329
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60320
- Product descriptionCFTRinh-172
- Packaging10mg
- Price$208
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15545
- Product descriptionCFTR Inhibitor-172 ≥98%
- Packaging5mg
- Price$81
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15545
- Product descriptionCFTR Inhibitor-172 ≥98%
- Packaging10mg
- Price$152
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15545
- Product descriptionCFTR Inhibitor-172 ≥98%
- Packaging25mg
- Price$356
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15545
- Product descriptionCFTR Inhibitor-172 ≥98%
- Packaging50mg
- Price$553
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM161930
- Product descriptionCFTR(inh)-172 98%
- Packaging10mg
- Price$113
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM161930
- Product descriptionCFTR(inh)-172 98%
- Packaging50mg
- Price$404
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3185
- Product descriptionCFTR(inh)-172 98.70%
- Packaging5mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3185
- Product descriptionCFTR(inh)-172 98.70%
- Packaging10mg
- Price$116
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3185
- Product descriptionCFTR(inh)-172 98.70%
- Packaging50mg
- Price$450
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2313AH | 4-[(E)-[4-oxo-2-Sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoicacid | 1g | $771 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0012817 | 4-[4-OXO-2-THIOXO-3-(3-TRIFLUOROMETHYL-PHENYL)-THIAZOLIDIN-(5Z)-YLIDENEMETHYL]-BENZOIC ACID 95.00% | 500MG | $589 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0012817 | 4-[4-OXO-2-THIOXO-3-(3-TRIFLUOROMETHYL-PHENYL)-THIAZOLIDIN-(5Z)-YLIDENEMETHYL]-BENZOIC ACID 95.00% | 1G | $778 | 2021-12-16 | Buy |
| ApexBio Technology | B1435 | CFTRinh-172 | 10mM(in 1mL DMSO) | $70 | 2021-12-16 | Buy |
| ApexBio Technology | B1435 | CFTRinh-172 | 10mg | $103 | 2021-12-16 | Buy |
| ApexBio Technology | B1435 | CFTRinh-172 | 50mg | $329 | 2021-12-16 | Buy |
| Arctom | CFN60320 | CFTRinh-172 | 10mg | $208 | 2021-12-16 | Buy |
| Cayman Chemical | 15545 | CFTR Inhibitor-172 ≥98% | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 15545 | CFTR Inhibitor-172 ≥98% | 10mg | $152 | 2024-03-01 | Buy |
| Cayman Chemical | 15545 | CFTR Inhibitor-172 ≥98% | 25mg | $356 | 2024-03-01 | Buy |
| Cayman Chemical | 15545 | CFTR Inhibitor-172 ≥98% | 50mg | $553 | 2024-03-01 | Buy |
| Chemenu | CM161930 | CFTR(inh)-172 98% | 10mg | $113 | 2021-12-16 | Buy |
| Chemenu | CM161930 | CFTR(inh)-172 98% | 50mg | $404 | 2021-12-16 | Buy |
| ChemScene | CS-3185 | CFTR(inh)-172 98.70% | 5mg | $70 | 2021-12-16 | Buy |
| ChemScene | CS-3185 | CFTR(inh)-172 98.70% | 10mg | $116 | 2021-12-16 | Buy |
| ChemScene | CS-3185 | CFTR(inh)-172 98.70% | 50mg | $450 | 2021-12-16 | Buy |
Properties
Melting point :181-183 °C
Boiling point :555.7±60.0 °C(Predicted)
Density :1.61±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
form :Yellow solid
pka :3.88±0.10(Predicted)
color :yellow
CAS DataBase Reference :307510-92-5
Boiling point :555.7±60.0 °C(Predicted)
Density :1.61±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
form :Yellow solid
pka :3.88±0.10(Predicted)
color :yellow
CAS DataBase Reference :307510-92-5
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Warning | ||||||||||||||||||||||||||||||||||||||||||
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Description
The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). CFTR Inhibitor-172 is a thiazolidinone that selectively blocks the CFTR channel (Ki = 300 nM) in a voltage-independent manner. It appears to directly modulate the gating of chloride at the channel and does not prevent elevation of cAMP or inhibit other pumps or channels. In mice, CFTR inhibitor-172 prevents cholera toxin-induced fluid secretion in the small intestine, when given by intraperitoneal injection. It slows cyst growth in animal models of polycystic kidney disease. As CFTR also modulates glutathione (GSH) efflux, CFTR inhibitor-172 can affect intracellular GSH concentration and reactive oxygen species balance.More related product prices
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
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