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ChemicalBook >> CAS DataBase List >> Aristolochic acid

Aristolochic acid

Aristolochic acid price.
  • $32 - $1732.5
  • Product name: Aristolochic acid
  • CAS: 313-67-7
  • MF: C17H11NO7
  • MW: 341.27
  • EINECS:206-238-3
  • MDL Number:MFCD00004996
  • Synonyms:Aristolochic acid, mixture of I and II, 96%;8-Methoxy-6-nitro-phenanthro[3,4-d]-1,3-dioxole-5-carboxylic Acid;Aristolochia A;Aristolochic Acid 1;NSC 11926;TR 1736;Aristolochic;Aristolochic acid (93% of Aristolochic acid I)
36 prices
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Brand
  • AHH
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • JR MediChem
  • Sigma-Aldrich
  • TRC
Package
  • y0001185
  • 10mg
  • 20mg
  • 25MG
  • 50mg
  • 100mg
  • 250MG
  • y0001323
  • 1g
  • ManufacturerAHH
  • Product numberMT-47223
  • Product descriptionAristolochicacid 97%
  • Packaging1g
  • Price$430
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA714436
  • Product descriptionAristolochicAcidA 99+%
  • Packaging100mg
  • Price$98
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0000398
  • Product descriptionARISTOLOCHIC ACID A 95.00%
  • Packaging250MG
  • Price$1732.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0000398
  • Product descriptionARISTOLOCHIC ACID A 95.00%
  • Packaging25MG
  • Price$180.6
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN2032
  • Product descriptionAristolochicAcidA
  • Packaging20mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberSY074862
  • Product descriptionAristolochicacidI,95% ≥98%
  • Packaging10mg
  • Price$95.45
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS643278
  • Product descriptionAristolochicAcidA ≥99%
  • Packaging100mg
  • Price$97
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN99505
  • Product descriptionAristolochicacidA ≥98%
  • Packaging20mg
  • Price$100
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number1871
  • Product descriptionAristolochic acid I
  • Packaging100mg
  • Price$249
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb545885
  • Product descriptionAristolochic acid >98%
  • Packaging20mg
  • Price$154.7
  • Updated2021-12-16
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  • ManufacturerBiorbyt Ltd
  • Product numberorb545885
  • Product descriptionAristolochic acid >98%
  • Packaging100mg
  • Price$389.3
  • Updated2021-12-16
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  • ManufacturerBiorbyt Ltd
  • Product numberorb105211
  • Product descriptionAristolochic acid >98%,Standard References Grade
  • Packaging20mg
  • Price$569.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA17982
  • Product descriptionAristolochic acid - Mixture of I and II
  • Packaging10mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA17982
  • Product descriptionAristolochic acid - Mixture of I and II
  • Packaging25mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberXA167153
  • Product descriptionAristolochic acid I
  • Packaging10mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberXA167153
  • Product descriptionAristolochic acid I
  • Packaging25mg
  • Price$175
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH MT-47223 Aristolochicacid 97% 1g $430 2021-12-16 Buy
Ambeed A714436 AristolochicAcidA 99+% 100mg $98 2021-12-16 Buy
American Custom Chemicals Corporation API0000398 ARISTOLOCHIC ACID A 95.00% 250MG $1732.5 2021-12-16 Buy
American Custom Chemicals Corporation API0000398 ARISTOLOCHIC ACID A 95.00% 25MG $180.6 2021-12-16 Buy
ApexBio Technology N2032 AristolochicAcidA 20mg $80 2021-12-16 Buy
Arctom SY074862 AristolochicacidI,95% ≥98% 10mg $95.45 2021-12-16 Buy
Arctom AS643278 AristolochicAcidA ≥99% 100mg $97 2021-12-16 Buy
Arctom CFN99505 AristolochicacidA ≥98% 20mg $100 2021-12-16 Buy
AvaChem 1871 Aristolochic acid I 100mg $249 2021-12-16 Buy
Biorbyt Ltd orb545885 Aristolochic acid >98% 20mg $154.7 2021-12-16 Buy
Biorbyt Ltd orb545885 Aristolochic acid >98% 100mg $389.3 2021-12-16 Buy
Biorbyt Ltd orb105211 Aristolochic acid >98%,Standard References Grade 20mg $569.5 2021-12-16 Buy
Biosynth Carbosynth FA17982 Aristolochic acid - Mixture of I and II 10mg $60 2021-12-16 Buy
Biosynth Carbosynth FA17982 Aristolochic acid - Mixture of I and II 25mg $120 2021-12-16 Buy
Biosynth Carbosynth XA167153 Aristolochic acid I 10mg $125 2021-12-16 Buy
Biosynth Carbosynth XA167153 Aristolochic acid I 25mg $175 2021-12-16 Buy

Properties

Melting point :260 °C
Boiling point :476.92°C (rough estimate)
Density :1.3162 (rough estimate)
refractive index :1.4500 (estimate)
storage temp. :2-8°C
solubility :DMSO: soluble
pka :2.99±0.20(Predicted)
form :powder
color :yellow
InChIKey :LIDQMWRBMLSXLL-UHFFFAOYSA-N
CAS DataBase Reference :313-67-7(CAS DataBase Reference)
IARC :1 (Vol. 82, 100A) 2012, 1 (Vol. 82, 100A) 2012

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger GHS hazard pictograms
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.

Description

Aristolochic Acid is an alkaloid that was originally derived from Aristolochia radix. This compound is a potent PLA2 enzyme inhibitor and also suppresses edema-inducing activity as well as direct and indirect hemolytic activity. Specifically, Aristolochic Acid displays anti-inflammatory activity against edema in mouse foot pads induced by PLA2. Other experiments have shown this agent to be associated with aristolochic acid nephropathy. Mechanistic studies have reported Aristolochic Acid to play a regulatory role towards genes in DNA repair processes and responses to DNA damage stimulus, regulation of cell cycle, and apoptosis. More detailed studies have shown this compound to up-regulate GADD 45β, NAIP genes and down-regulate TP53, PARP1, ERCC1, OGG1/2, MGMT, and ERCC2 genes. Furthermore, a down-regulation of gene expression in anti-oxidant enzymes was also observed by Aristolochic Acid treatment of human kidney tubular cells. These studies suggest that oxidative stress plays a role in the cytotoxicity of Aristolochic Acid.

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