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ChemicalBook >> CAS DataBase List >> 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine price.
  • $9 - $1802
  • Product name: 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
  • CAS: 500579-04-4
  • MF: C27H35N5
  • MW: 429.6
  • EINECS:
  • MDL Number:MFCD14635408
  • Synonyms:2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine;GANT 61;Benzenamine, 2,2'-[[dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl-;2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine] GANT61;GNT61;NSC 136476;GANT61, >=98%;GANT-61,NSC 136476
42 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
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  • 2mg
  • 1mg
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  • 10mg
  • 25mg
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  • 1g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3561-M001
  • Product descriptionGANT61 ≥98%
  • Packaging1mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2423AH
  • Product descriptionGANT61
  • Packaging10mg
  • Price$164
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109328
  • Product description2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+%
  • Packaging1mg
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109328
  • Product description2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+%
  • Packaging5mg
  • Price$19
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109328
  • Product description2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+%
  • Packaging10mg
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109328
  • Product description2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+%
  • Packaging50mg
  • Price$68
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109328
  • Product description2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+%
  • Packaging100mg
  • Price$101
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109328
  • Product description2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+%
  • Packaging250mg
  • Price$172
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109328
  • Product description2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+%
  • Packaging1g
  • Price$437
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1615
  • Product descriptionGANT61
  • Packaging25mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2642
  • Product descriptionGANT61-NSC136476 99%
  • Packaging50mg
  • Price$462
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181000
  • Product descriptionGANT61(NSC 136476) >98%
  • Packaging100mg
  • Price$606.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181000
  • Product descriptionGANT61(NSC 136476) >98%
  • Packaging250mg
  • Price$912.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181000
  • Product descriptionGANT61(NSC 136476) >98%
  • Packaging1000mg
  • Price$1802
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFG137676
  • Product descriptionGANT 61
  • Packaging10mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFG137676
  • Product descriptionGANT 61
  • Packaging50mg
  • Price$297.5
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3561-M001 GANT61 ≥98% 1mg $40 2021-12-16 Buy
AK Scientific 2423AH GANT61 10mg $164 2021-12-16 Buy
Ambeed A109328 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+% 1mg $9 2021-12-16 Buy
Ambeed A109328 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+% 5mg $19 2021-12-16 Buy
Ambeed A109328 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+% 10mg $28 2021-12-16 Buy
Ambeed A109328 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+% 50mg $68 2021-12-16 Buy
Ambeed A109328 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+% 100mg $101 2021-12-16 Buy
Ambeed A109328 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+% 250mg $172 2021-12-16 Buy
Ambeed A109328 2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline) 98+% 1g $437 2021-12-16 Buy
ApexBio Technology A1615 GANT61 25mg $150 2021-12-16 Buy
Axon Medchem Axon2642 GANT61-NSC136476 99% 50mg $462 2021-12-16 Buy
Biorbyt Ltd orb181000 GANT61(NSC 136476) >98% 100mg $606.9 2021-12-16 Buy
Biorbyt Ltd orb181000 GANT61(NSC 136476) >98% 250mg $912.9 2021-12-16 Buy
Biorbyt Ltd orb181000 GANT61(NSC 136476) >98% 1000mg $1802 2021-12-16 Buy
Biosynth Carbosynth FG137676 GANT 61 10mg $85 2021-12-16 Buy
Biosynth Carbosynth FG137676 GANT 61 50mg $297.5 2021-12-16 Buy

Properties

Melting point :110 - 113°C
Boiling point :549.0±50.0 °C(Predicted)
Density :1.134±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >2mg/mL
pka :5.97±0.10(Predicted)
form :powder
color :white to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Hedgehog proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the GLI family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the GLI proteins are named. GANT 61 is a GLI antagonist, inhibiting GLI1 activation of gene expression with an IC50 value of 5 μM. It does not affect signaling through NF-κB, glucocorticoid receptor, MAPK, HGF, C/EBPα, or HIF-1, supporting specificity for the Hedgehog pathway. GANT 61 has been shown to inhibit the in vitro proliferation of PANC-1 and 22Rv1 cancer cells, which have elevated GLI1 levels, and prevent the development of 22Rv1 tumors in mice.

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