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ChemicalBook >> CAS DataBase List >> 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile

4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile

4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile price.
  • $12 - $2194.5
  • Product name: 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile
  • CAS: 500287-72-9
  • MF: C22H18N6
  • MW: 366.42
  • EINECS:
  • MDL Number:MFCD11046372
  • Synonyms:4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile;4-[[4-[[4-[(E)-2-Cyanovinyl]-2,6-diMethylphenyl]aMino]pyriMidin-2-yl]aMino]benzonitrile;4-{[4-({4-[(1E)-2-cyanoeth-1-en-1-yl]-2,6-diMethylphenyl}aMino)pyriMidin-2-yl]aMino}benzonitrile;Rilpivirine(R 278474;Rilpivirine (R 278474, TMC 278);4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile;R 278474;TMC 278
31 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • TRC
  • Usbiological
Package
  • 1mg
  • 2.5mg
  • 5mg
  • 10mg
  • 10mM(in 1mL DMSO)
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • 1000mg
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3750-M025
  • Product descriptionRilpivirine ≥98%(HPLC)
  • Packaging25mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberW9902
  • Product descriptionRilpivirine
  • Packaging50mg
  • Price$473
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA112484
  • Product description(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+%
  • Packaging1mg
  • Price$12
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA112484
  • Product description(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+%
  • Packaging5mg
  • Price$21
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA112484
  • Product description(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+%
  • Packaging10mg
  • Price$27
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA112484
  • Product description(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+%
  • Packaging50mg
  • Price$46
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA112484
  • Product description(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+%
  • Packaging100mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA112484
  • Product description(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+%
  • Packaging250mg
  • Price$116
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA112484
  • Product description(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+%
  • Packaging1g
  • Price$289
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008127
  • Product descriptionRILPIVIRINE 95.00%
  • Packaging10MG
  • Price$299.25
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008127
  • Product descriptionRILPIVIRINE 95.00%
  • Packaging25MG
  • Price$2194.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3765
  • Product descriptionRilpivirine
  • Packaging10mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3765
  • Product descriptionRilpivirine
  • Packaging10mM(in 1mL DMSO)
  • Price$173
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3765
  • Product descriptionRilpivirine
  • Packaging50mg
  • Price$469
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181114
  • Product descriptionRilpivirine(R 278474, TMC 278) >98%
  • Packaging100mg
  • Price$606.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181114
  • Product descriptionRilpivirine(R 278474, TMC 278) >98%
  • Packaging250mg
  • Price$838.1
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3750-M025 Rilpivirine ≥98%(HPLC) 25mg $200 2021-12-16 Buy
AK Scientific W9902 Rilpivirine 50mg $473 2021-12-16 Buy
Ambeed A112484 (E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+% 1mg $12 2021-12-16 Buy
Ambeed A112484 (E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+% 5mg $21 2021-12-16 Buy
Ambeed A112484 (E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+% 10mg $27 2021-12-16 Buy
Ambeed A112484 (E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+% 50mg $46 2021-12-16 Buy
Ambeed A112484 (E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+% 100mg $60 2021-12-16 Buy
Ambeed A112484 (E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+% 250mg $116 2021-12-16 Buy
Ambeed A112484 (E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+% 1g $289 2021-12-16 Buy
American Custom Chemicals Corporation API0008127 RILPIVIRINE 95.00% 10MG $299.25 2021-12-16 Buy
American Custom Chemicals Corporation API0008127 RILPIVIRINE 95.00% 25MG $2194.5 2021-12-16 Buy
ApexBio Technology A3765 Rilpivirine 10mg $140 2021-12-16 Buy
ApexBio Technology A3765 Rilpivirine 10mM(in 1mL DMSO) $173 2021-12-16 Buy
ApexBio Technology A3765 Rilpivirine 50mg $469 2021-12-16 Buy
Biorbyt Ltd orb181114 Rilpivirine(R 278474, TMC 278) >98% 100mg $606.9 2021-12-16 Buy
Biorbyt Ltd orb181114 Rilpivirine(R 278474, TMC 278) >98% 250mg $838.1 2021-12-16 Buy

Properties

Melting point :245℃
Boiling point :634.1±65.0 °C(Predicted)
Density :1.27
storage temp. :Refrigerator
solubility :Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Water (Very Slightly)
pka :4.56±0.10(Predicted)
form :Solid
color :Yellow

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330 Rinse mouth.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

In May 2011, the U.S. FDA approved rilpivirine in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV) 1 infection in treatment-naive adult patients. Rilpivirine is a member of the nonnucleoside reverse transcriptase inhibitor (NNRTI) class of anti-HIV agents. It is highly potent against a range of wild-type HIV strains (EC50=0.07–1.0 nM),～10–20 timesmore potent than the NNRTI efavirenz (Sustiva), and active against HIV strains resistant to other NNRTIs. The discovery of rilpivirine was guided by molecular modeling and X-ray crystallography of HIV-1 RT complexed with inhibitors. The synthesis of rilpivirine is accomplished by an efficient 6-step route in which the key step is coupling of 4-((4-chloropyrimidin-2-yl)amino)benzonitrile with (E)-3-(4-amino-3,5-dimethylphenyl)acrylonitrile.