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ChemicalBook >> CAS DataBase List >> 4-HYDROXYPHENYLRETINAMIDE

4-HYDROXYPHENYLRETINAMIDE

4-HYDROXYPHENYLRETINAMIDE price.
  • $38 - $4435.3
  • Product name: 4-HYDROXYPHENYLRETINAMIDE
  • CAS: 65646-68-6
  • MF: C26H33NO2
  • MW: 391.55
  • EINECS:200-256-5
  • MDL Number:MFCD00792674
  • Synonyms:4-HYDROXYPHENYLRETINAMIDE;4HPR;FENRETINIDE;p-Hydroxyphenylretinamide;4-HPR, Fenretinide, N-(4-Hydroxyphenyl)retinamide;(2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenamide;Fenretinimide;Fenretinide(4-HPR)
57 prices
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Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological
Package
  • 50
  • 10mg
  • 25MG
  • 5MG
  • 50mg
  • 10
  • 100mg
  • 100ul
  • 200mg
  • 250mg
  • 1g
  • 10mM(in 1mL DMSO)
  • 500mg
  • 2g
  • 5G
  • 96Tests
  • 400μl
  • ManufacturerAK Scientific
  • Product number3670AH
  • Product descriptionFenretinide
  • Packaging10mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3670AH
  • Product descriptionFenretinide
  • Packaging50mg
  • Price$262
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA129384
  • Product description(2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide 98+%
  • Packaging10mg
  • Price$43
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA129384
  • Product description(2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide 98+%
  • Packaging50mg
  • Price$72
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA129384
  • Product description(2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide 98+%
  • Packaging100mg
  • Price$93
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA129384
  • Product description(2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide 98+%
  • Packaging250mg
  • Price$198
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA129384
  • Product description(2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide 98+%
  • Packaging1g
  • Price$456
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0005890
  • Product descriptionFENRETINIDE 95.00%
  • Packaging5MG
  • Price$160.6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0005890
  • Product descriptionFENRETINIDE 95.00%
  • Packaging25MG
  • Price$721.88
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0005890
  • Product descriptionFENRETINIDE 95.00%
  • Packaging250MG
  • Price$1732.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3412
  • Product descriptionFenretinide
  • Packaging10mg
  • Price$47
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3412
  • Product descriptionFenretinide
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3412
  • Product descriptionFenretinide
  • Packaging50mg
  • Price$74
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS444378
  • Product descriptionFenretinide ≥98%
  • Packaging100mg
  • Price$92
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS444378
  • Product descriptionFenretinide ≥98%
  • Packaging250mg
  • Price$196
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546045
  • Product descriptionFenretinide (4-HPR) >98%
  • Packaging10mg
  • Price$187
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3670AH Fenretinide 10mg $110 2021-12-16 Buy
AK Scientific 3670AH Fenretinide 50mg $262 2021-12-16 Buy
Ambeed A129384 (2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide 98+% 10mg $43 2021-12-16 Buy
Ambeed A129384 (2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide 98+% 50mg $72 2021-12-16 Buy
Ambeed A129384 (2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide 98+% 100mg $93 2021-12-16 Buy
Ambeed A129384 (2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide 98+% 250mg $198 2021-12-16 Buy
Ambeed A129384 (2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide 98+% 1g $456 2021-12-16 Buy
American Custom Chemicals Corporation API0005890 FENRETINIDE 95.00% 5MG $160.6 2021-12-16 Buy
American Custom Chemicals Corporation API0005890 FENRETINIDE 95.00% 25MG $721.88 2021-12-16 Buy
American Custom Chemicals Corporation API0005890 FENRETINIDE 95.00% 250MG $1732.5 2021-12-16 Buy
ApexBio Technology A3412 Fenretinide 10mg $47 2021-12-16 Buy
ApexBio Technology A3412 Fenretinide 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology A3412 Fenretinide 50mg $74 2021-12-16 Buy
Arctom AS444378 Fenretinide ≥98% 100mg $92 2021-12-16 Buy
Arctom AS444378 Fenretinide ≥98% 250mg $196 2021-12-16 Buy
Biorbyt Ltd orb546045 Fenretinide (4-HPR) >98% 10mg $187 2021-12-16 Buy

Properties

Melting point :162-163°C
Boiling point :597.6±42.0 °C(Predicted)
Density :1.081±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Chloroform (Slightly), Methanol (Slightly)
form :Orange solid
pka :9.98±0.26(Predicted)
color :Yellow
λmax :362nm(MeOH)(lit.)
Merck :14,3998
Stability :Light Sensitive - Protect from Light Exposure
InChIKey :AKJHMTWEGVYYSE-FXILSDISSA-N
CAS DataBase Reference :65646-68-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Fenretinide is a synthetic retinoic acid that induces ceramide in tumor cell lines, leading to caspase-dependent apoptosis (IC50 = 2.4 μM). It promotes the generation of reactive oxygen species, the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ. At 5-20 μM, fenretinide selectively activates retinoic acid receptor γ and is reported to inhibit the growth of Caov-3, OVCAR-3, and SK-OV-3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 μM, respectively.

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