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ChemicalBook >> CAS DataBase List >> BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-

BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-

BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- price.
  • $55 - $1450
  • Product name: BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-
  • CAS: 1054543-47-3
  • MF: C33H25F6N3O3
  • MW: 625.56
  • EINECS:604-604-1
  • MDL Number:MFCD19443178
  • Synonyms:BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-;Apoptosis Activator VII, Apoptozole;6-BROMO-4-CHLOROQUINOLINE HYDROCHLORIDE (1:1);5-bis(trifluoroMethyl)phenyl]-4;5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-;Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem;4-({2-[3,5-Bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)-1 H-imidazol-1-yl}methyl)benzamide;Apoptozole，Apoptosis Activator VII
21 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • TRC
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number1922DC
  • Product descriptionApoptozole
  • Packaging25mg
  • Price$459
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA102708
  • Product descriptionApoptozole 98+%
  • Packaging5mg
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA102708
  • Product descriptionApoptozole 98+%
  • Packaging10mg
  • Price$77
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA102708
  • Product descriptionApoptozole 98+%
  • Packaging50mg
  • Price$131
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberHCH0316515
  • Product description4-[[2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-4,5-BIS-(4-METHOXYPHENYL)-1H-IMIDAZOL-1-YL]METHYL]BENZAMIDE 95.00%
  • Packaging5MG
  • Price$501.61
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC4803
  • Product descriptionApoptozole
  • Packaging5mg
  • Price$82
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC4803
  • Product descriptionApoptozole
  • Packaging10mg
  • Price$154
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC4803
  • Product descriptionApoptozole
  • Packaging25mg
  • Price$369
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC4803
  • Product descriptionApoptozole
  • Packaging50mg
  • Price$654
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2251
  • Product descriptionApoptozole 100%
  • Packaging10mg
  • Price$104.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17675
  • Product descriptionApoptozole ≥98%
  • Packaging50mg
  • Price$468
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17675
  • Product descriptionApoptozole ≥98%
  • Packaging25mg
  • Price$270
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17675
  • Product descriptionApoptozole ≥98%
  • Packaging10mg
  • Price$116
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17675
  • Product descriptionApoptozole ≥98%
  • Packaging5mg
  • Price$73
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5990
  • Product descriptionApoptozole 99.97%
  • Packaging5mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5990
  • Product descriptionApoptozole 99.97%
  • Packaging10mg
  • Price$95
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1922DC Apoptozole 25mg $459 2021-12-16 Buy
Ambeed A102708 Apoptozole 98+% 5mg $59 2021-12-16 Buy
Ambeed A102708 Apoptozole 98+% 10mg $77 2021-12-16 Buy
Ambeed A102708 Apoptozole 98+% 50mg $131 2021-12-16 Buy
American Custom Chemicals Corporation HCH0316515 4-[[2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-4,5-BIS-(4-METHOXYPHENYL)-1H-IMIDAZOL-1-YL]METHYL]BENZAMIDE 95.00% 5MG $501.61 2021-12-16 Buy
ApexBio Technology C4803 Apoptozole 5mg $82 2021-12-16 Buy
ApexBio Technology C4803 Apoptozole 10mg $154 2021-12-16 Buy
ApexBio Technology C4803 Apoptozole 25mg $369 2021-12-16 Buy
ApexBio Technology C4803 Apoptozole 50mg $654 2021-12-16 Buy
Axon Medchem Axon2251 Apoptozole 100% 10mg $104.5 2021-12-16 Buy
Cayman Chemical 17675 Apoptozole ≥98% 50mg $468 2024-03-01 Buy
Cayman Chemical 17675 Apoptozole ≥98% 25mg $270 2024-03-01 Buy
Cayman Chemical 17675 Apoptozole ≥98% 10mg $116 2024-03-01 Buy
Cayman Chemical 17675 Apoptozole ≥98% 5mg $73 2024-03-01 Buy
ChemScene CS-5990 Apoptozole 99.97% 5mg $55 2021-12-16 Buy
ChemScene CS-5990 Apoptozole 99.97% 10mg $95 2021-12-16 Buy

Properties

Melting point :225-228°C
Boiling point :703.5±70.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form :White solid
pka :15.98±0.50(Predicted)
color :White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. It does not act on Hsp40, Hsp60, or Hsp90. Apoptozole dose-dependently induces apoptosis in cancer cells (IC50 = 5-7 μM). It prevents the association of Hsp70 with apoptotic protease-activating factor 1 and triggers caspase activation in HeLa cells. Apoptozole (10 mg/kg, i.p.) prevents the growth of A549, RKO, and HeLa cell xenografts in mice without significant loss of body weight.