1-METHYL-D-TRYPTOPHAN
|
- $37 - $2320
- Product name: 1-METHYL-D-TRYPTOPHAN
- CAS: 110117-83-4
- MF: C12H14N2O2
- MW: 218.25
- EINECS:
- MDL Number:MFCD00274271
- Synonyms:1-METHYL-D-TRYPTOPHAN;1-Methyl-D-tryptophane;1-METHYL-D-TRYPTOPHAN 95%;(R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid;IndoxiMod;Indoximod (NLG-8189）;NLG-8189;1-Me-D-Trp
19 prices
Selected condition：
Brand
- Acrotein
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
Package
- 50mg
- 200mg
- 250mg
- 500mg
- 50
- 1g
- 5g
- 10G
- 25g
- ManufacturerAcrotein
- Product numberNA-2694
- Product description1-Methyl-D-tryptophan 97%
- Packaging1g
- Price$165
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ52918
- Product description1-Methyl-D-tryptophan
- Packaging5g
- Price$320
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0006850
- Product description1-METHYL-D-TRYPTOPHAN 95.00%
- Packaging1G
- Price$679.28
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0006850
- Product description1-METHYL-D-TRYPTOPHAN 95.00%
- Packaging5G
- Price$1085.24
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0006850
- Product description1-METHYL-D-TRYPTOPHAN 95.00%
- Packaging10G
- Price$1622.89
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4900
- Product descriptionIndoximod(NLG-8189)
- Packaging200mg
- Price$63
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4900
- Product descriptionIndoximod(NLG-8189)
- Packaging50mg
- Price$38
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16456
- Product description1-methyl-D-Tryptophan ≥95%
- Packaging250mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16456
- Product description1-methyl-D-Tryptophan ≥95%
- Packaging500mg
- Price$65
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16456
- Product description1-methyl-D-Tryptophan ≥95%
- Packaging1g
- Price$115
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16456
- Product description1-methyl-D-Tryptophan ≥95%
- Packaging5g
- Price$474
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-4941
- Product descriptionIndoximod 99.39%
- Packaging250mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8021
- Product descriptionIndoximod(NLG-8189) >98%
- Packaging1g
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number52384
- Product description1-Methyl-D-tryptophan
- Packaging25g
- Price$2320
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product number452483
- Product description1-Methyl-D-tryptophan 95%
- Packaging250mg
- Price$47
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product number452483
- Product description1-Methyl-D-tryptophan 95%
- Packaging1g
- Price$146
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Acrotein | NA-2694 | 1-Methyl-D-tryptophan 97% | 1g | $165 | 2021-12-16 | Buy |
| AK Scientific | J52918 | 1-Methyl-D-tryptophan | 5g | $320 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0006850 | 1-METHYL-D-TRYPTOPHAN 95.00% | 1G | $679.28 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0006850 | 1-METHYL-D-TRYPTOPHAN 95.00% | 5G | $1085.24 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0006850 | 1-METHYL-D-TRYPTOPHAN 95.00% | 10G | $1622.89 | 2021-12-16 | Buy |
| ApexBio Technology | B4900 | Indoximod(NLG-8189) | 200mg | $63 | 2021-12-16 | Buy |
| ApexBio Technology | B4900 | Indoximod(NLG-8189) | 50mg | $38 | 2021-12-16 | Buy |
| Cayman Chemical | 16456 | 1-methyl-D-Tryptophan ≥95% | 250mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 16456 | 1-methyl-D-Tryptophan ≥95% | 500mg | $65 | 2024-03-01 | Buy |
| Cayman Chemical | 16456 | 1-methyl-D-Tryptophan ≥95% | 1g | $115 | 2024-03-01 | Buy |
| Cayman Chemical | 16456 | 1-methyl-D-Tryptophan ≥95% | 5g | $474 | 2024-03-01 | Buy |
| ChemScene | CS-4941 | Indoximod 99.39% | 250mg | $60 | 2021-12-16 | Buy |
| DC Chemicals | DC8021 | Indoximod(NLG-8189) >98% | 1g | $450 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 52384 | 1-Methyl-D-tryptophan | 25g | $2320 | 2021-12-16 | Buy |
| Sigma-Aldrich | 452483 | 1-Methyl-D-tryptophan 95% | 250mg | $47 | 2024-03-01 | Buy |
| Sigma-Aldrich | 452483 | 1-Methyl-D-tryptophan 95% | 1g | $146 | 2024-03-01 | Buy |
Properties
Melting point :242-245 °C(lit.)
alpha :12.4o (C = 2 IN ACETIC ACID)
Boiling point :429.3±35.0 °C(Predicted)
Density :1.28
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :Soluble in DMSO (greater than 25 mg/ml).
pka :2.26±0.10(Predicted)
form :White to light brown crystalline powder.
color :White
optical activity :[α]22/D +12.4°, c = 2 in acetic acid
Water Solubility :Soluble to 5 mM in water with gentle warming
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey :ZADWXFSZEAPBJS-SNVBAGLBSA-N
alpha :12.4o (C = 2 IN ACETIC ACID)
Boiling point :429.3±35.0 °C(Predicted)
Density :1.28
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :Soluble in DMSO (greater than 25 mg/ml).
pka :2.26±0.10(Predicted)
form :White to light brown crystalline powder.
color :White
optical activity :[α]22/D +12.4°, c = 2 in acetic acid
Water Solubility :Soluble to 5 mM in water with gentle warming
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey :ZADWXFSZEAPBJS-SNVBAGLBSA-N
Safety Information
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Description
Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.Related product price
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