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ChemicalBook >> CAS DataBase List >> α-Naphthoflavone

α-Naphthoflavone

α-Naphthoflavone price.
  • $18 - $975
  • Product name: α-Naphthoflavone
  • CAS: 604-59-1
  • MF: C19H12O2
  • MW: 272.3
  • EINECS:210-071-1
  • MDL Number:MFCD00004985
  • Synonyms:7,8-BENZOFLAVONE;ALPHA-NAPHTHOFLAVONE;A-NAPHTHOFLAVANONE;A-NAPHTHOFLAVONE;BENZOFLAVONE;NAPHTHOFLAVANONE, A-;NAPHTHOFLAVONE, A-;2-b)pyran-4-one,2-phenyl-4h-naphtho(
37 prices
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Brand
  • AK Scientific
  • Alfa Aesar
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • AvaChem
  • Biosynth Carbosynth
  • Cayman Chemical
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • SynQuest Laboratories
  • TCI Chemical
  • TRC
Package
  • 10mg
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  • ManufacturerAK Scientific
  • Product numberJ54118
  • Product description2-Phenyl-4H-benzo[h]chromen-4-one
  • Packaging5g
  • Price$20
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberA18542
  • Product descriptionalpha-Naphthoflavone, 97%
  • Packaging5g
  • Price$51.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberA18542
  • Product descriptionalpha-Naphthoflavone, 97%
  • Packaging25g
  • Price$215.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberPXT0004616
  • Product descriptionALPHA-NAPHTHOFLAVONE 95.00%
  • Packaging1G
  • Price$430.2
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberPXT0004616
  • Product descriptionALPHA-NAPHTHOFLAVONE 95.00%
  • Packaging5G
  • Price$469.3
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberPXT0004616
  • Product descriptionALPHA-NAPHTHOFLAVONE 95.00%
  • Packaging25G
  • Price$746.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3353
  • Product descriptionα-Naphthoflavone
  • Packaging10g
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberOR1158
  • Product descriptionalpha-Naphthoflavone
  • Packaging5g
  • Price$111
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberOR1158
  • Product descriptionalpha-Naphthoflavone
  • Packaging25g
  • Price$279
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberOR1158
  • Product descriptionalpha-Naphthoflavone
  • Packaging100g
  • Price$595
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN94465
  • Product description7,8-Benzoflavone
  • Packaging20mg
  • Price$40
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number4501
  • Product descriptionalpha-Naphthylflavone
  • Packaging10mg
  • Price$29
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number4501
  • Product descriptionalpha-Naphthylflavone
  • Packaging20mg
  • Price$39
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number4501
  • Product descriptionalpha-Naphthylflavone
  • Packaging100mg
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB09432
  • Product description7,8-Benzoflavone
  • Packaging10g
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB09432
  • Product description7,8-Benzoflavone
  • Packaging25g
  • Price$70
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J54118 2-Phenyl-4H-benzo[h]chromen-4-one 5g $20 2021-12-16 Buy
Alfa Aesar A18542 alpha-Naphthoflavone, 97% 5g $51.65 2024-03-01 Buy
Alfa Aesar A18542 alpha-Naphthoflavone, 97% 25g $215.65 2024-03-01 Buy
American Custom Chemicals Corporation PXT0004616 ALPHA-NAPHTHOFLAVONE 95.00% 1G $430.2 2021-12-16 Buy
American Custom Chemicals Corporation PXT0004616 ALPHA-NAPHTHOFLAVONE 95.00% 5G $469.3 2021-12-16 Buy
American Custom Chemicals Corporation PXT0004616 ALPHA-NAPHTHOFLAVONE 95.00% 25G $746.5 2021-12-16 Buy
ApexBio Technology C3353 α-Naphthoflavone 10g $135 2021-12-16 Buy
Apolloscientific OR1158 alpha-Naphthoflavone 5g $111 2021-12-16 Buy
Apolloscientific OR1158 alpha-Naphthoflavone 25g $279 2021-12-16 Buy
Apolloscientific OR1158 alpha-Naphthoflavone 100g $595 2021-12-16 Buy
Arctom CFN94465 7,8-Benzoflavone 20mg $40 2021-12-16 Buy
AvaChem 4501 alpha-Naphthylflavone 10mg $29 2021-12-16 Buy
AvaChem 4501 alpha-Naphthylflavone 20mg $39 2021-12-16 Buy
AvaChem 4501 alpha-Naphthylflavone 100mg $49 2021-12-16 Buy
Biosynth Carbosynth FB09432 7,8-Benzoflavone 10g $40 2021-12-16 Buy
Biosynth Carbosynth FB09432 7,8-Benzoflavone 25g $70 2021-12-16 Buy

Properties

Melting point :153-157 °C (lit.)
Boiling point :375.35°C (rough estimate)
Density :1.1382 (rough estimate)
refractive index :1.5510 (estimate)
storage temp. :2-8°C
solubility :Chloroform (Slightly), Ethyl Acetate (Slightly)
form :Crystalline Powder or Crystals
color :yellow
BRN :210862
Stability :Stable. Incompatible with strong oxidizing agents.
LogP :5.003 (est)
CAS DataBase Reference :604-59-1(CAS DataBase Reference)
EPA Substance Registry System :4H-Naphtho[1,2-b]pyran-4-one, 2-phenyl- (604-59-1)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.

Description

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. α-Naphthoflavone is a flavone that modulates xenobiotic metabolism at several points. It antagonizes AhR, blocking the expression of phase I and II genes at nanomolar concentrations, although it can agonize AhR at higher concentrations (10 μM). α-Naphthoflavone inhibits CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 μM). Dietary α-naphthoflavone can contribute to carcinogenesis in the presence of synthetic estrogens.

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