Chemical Safety Data Sheet MSDS / SDS

Trifluoroacetic anhydride

Revision Date:2024-12-21Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: Trifluoroacetic anhydride
CBnumber: CB6853606
CAS: 407-25-0
EINECS Number: 206-982-9
Synonyms: TFAA,trifluoroacetic anhydride

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P405 Store locked up.

P310 Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P273 Avoid release to the environment.

Hazard statements

H412 Harmful to aquatic life with long lasting effects

H402 Harmful to aquatic life

H332 Harmful if inhaled

H318 Causes serious eye damage

H314 Causes severe skin burns and eye damage

SECTION 3: Composition/information on ingredients

Substance

Product name: Trifluoroacetic anhydride
Synonyms: TFAA,trifluoroacetic anhydride
CAS: 407-25-0
EC number: 206-982-9
MF: C4F6O3
MW: 210.03

SECTION 4: First aid measures

Description of first aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Dry powder Dry sand

Unsuitable extinguishing media

Do NOT use water jet.

Special hazards arising from the substance or mixture

Carbon oxides, Hydrogen fluoride Not combustible.

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

Further information

No data available

NFPA 704

HEALTH	3	Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
FIRE	0	Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride)
REACT	1	Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.

For personal protection see section 8.

Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up

Soak up with inert absorbent material and dispose of as hazardous waste. Do not flush with water. Keep in suitable, closed containers for disposal.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store in cool place. Never allow product to get in contact with water during storage.

Hygroscopic. Store under inert gas.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection

Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.

Full contact

Material: Nature latex/chloroprene Minimum layer thickness: 0,6 mm Break through time: 480 min

Material tested:Lapren? (KCL 706 / Aldrich Z677558, Size M)

Splash contact Material: Nitrile rubber

Minimum layer thickness: 0,11 mm Break through time: 38 min

Material tested:Dermatril? (KCL 740 / Aldrich Z677272, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Complete suit protecting against chemicals, Flame retardant protective clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearancecolourless, to, light yellow clear, liquid
Odourpungent
Odour ThresholdNo data available
pHNo data available
Melting point/freezing pointMelting point/range: -65 °C - lit.
Initial boiling point and boiling range39,5 - 40 °C - lit.
Flash point-26 °C
Evaporation rateNo data available
Flammability (solid, gas)No data available
Upper/lower flammability or explosive limitsNo data available
Vapour pressure433 hPa at 20 °C - Regulation (EC) No. 440/2008, Annex, A.4
Vapour densityNo data available
Relative density1,511 g/cm3 at 20 °C - lit.
Water solubility10.000 g/l - US-EPA - completely soluble
Partition coefficient: n-octanol/waterNo data available
Autoignition temperatureNo data available
Decomposition temperatureNo data available
ViscosityNo data available
Explosive propertiesNo data available
Oxidizing propertiesNo data available

Other safety information

Surface tension 72,5 mN/m at 1g/l at 20 °C

- OECD Test Guideline 115

SECTION 10: Stability and reactivity

Reactivity

Reacts violently with water.

Chemical stability

Stable under recommended storage conditions.

Possibility of hazardous reactions

Reacts violently with water.

Conditions to avoid

Exposure to moisture

Incompatible materials

Strong oxidizing agents, Strong acids, Strong bases, Alcohols

Hazardous decomposition products

Hazardous decomposition products formed under fire conditions. - Carbon oxides, Hydrogen fluoride

Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

No data available

Skin corrosion/irritation

Skin - In vitro study
Result: Extremely corrosive and destructive to tissue. (OECD Test Guideline 435)
Tendency of poor wound-healing after penetration of the substance.

Serious eye damage/eye irritation

Causes serious eye damage.

Respiratory or skin sensitisation

(OECD Test Guideline 429)
Remarks: (in analogy to similar products)

Germ cell mutagenicity

In vitro mammalian cell gene mutation test mouse lymphoma cells
Result: negative
(in analogy to similar products)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

Specific target organ toxicity - single exposure

No data available
Acute oral toxicity - If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the oesophagus and the stomach.
Acute inhalation toxicity - burns of mucous membranes, Cough, Shortness of breath, Inhalation may lead to the formation of oedemas in the respiratory tract., Possible damages:, damage of respiratory tract

Specific target organ toxicity - repeated exposure Aspiration hazard

Additional Information

RTECS: AJ9800000
Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., Cough, Shortness of breath, Headache, Nausea
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Decomposition of the substance with tissue moisture. Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.

Toxicity

skn-rbt 500 mg/24H SEV 28ZPAK -,91,72