Tolylene-2,4-diisocyanate
Product identifier
- Product name: Tolylene-2,4-diisocyanate
- CBnumber: CB6170855
- CAS: 584-84-9
- EINECS Number: 209-544-5
- Synonyms: TDI,TDI-80
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: Tolylene-2,4-diisocyanate
- Synonyms: TDI,TDI-80
- CAS: 584-84-9
- EC number: 209-544-5
- MF: C9H6N2O2
- MW: 174.16
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides Nitrogen oxides (NOx)
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
Further information
No data available
NFPA 704
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 2 | Undergoes violent chemical change at elevated temperatures and pressures, reacts violently with water, or may form explosive mixtures with water (e.g. white phosphorus, potassium, sodium) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
For personal protection see section 8.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Advice on safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapor or mist.
Hygiene measures
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Storage conditions
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Store under inert gas. Moisture sensitive. Product is sensitive to light and moisture.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Personal protective equipmentFace shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Full contact
Material: butyl-rubber
Minimum layer thickness: 0,3 mm Break through time: 480 min
Material tested:Butoject? (KCL 897 / Aldrich Z677647, Size M)
Splash contact Material: Nitrile rubber
Minimum layer thickness: 0,11 mm Break through time: 240 min
Material tested:Dermatril? (KCL 740 / Aldrich Z677272, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
Information on basic physicochemical properties
- Appearancecolorless clear, liquid
- OdourNo data available
- Odour ThresholdNo data available
- pHNo data available
- Melting point/freezing pointMelting point/range: 19,5 - 21,5 °C - lit.
- Initial boiling point and boiling range 124 - 126 °C at 24 hPa - lit. 251 °C - lit.
- Flash point132 °C - closed cup
- Evaporation rateNo data available
- Flammability (solid, gas)No data available
- Upper/lower flammability or explosive limits Upper explosion limit: 9,5 %(V) Lower explosion limit: 0,9 %(V)
- Vapour pressure 0,04 hPa at 25 °C
- Vapour density 6,01 - (Air = 1.0)
- Relative density1.225
- Water solubilityMiscible with ether, acetone, benzene, carbontetrachloride and chlorobenzene.
- Partition coefficient: n-octanol/waterlog Pow: 3,43 at 22 °C
- Autoignition temperatureNo data available
- Decomposition temperatureNo data available
- ViscosityViscosity, kinematic: 2 mm2/s at 21 °C Viscosity, dynamic: No data available
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
Other safety information
Surface tension 25 mN/m at 25 °C
Relative vapor density
6,01 - (Air = 1.0)
Reactivity
No data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
No data available
Conditions to avoid
Heat.
Incompatible materials
Alcohols, Strong bases, Amines, acids, Strong oxidizing agents
Hazardous decomposition products
In the event of fire: see section 5
Information on toxicological effects
Acute toxicityRemarks: (in analogy to similar compounds)
The value is given in analogy to the following substances: m-tolylidene diisocyanate LC50 Inhalation - Rat - male and female - 4 h - 0,12 mg/l
(OECD Test Guideline 403)
Remarks: (in analogy to similar products)
LD50 Dermal - Rabbit - male and female - > 9.400 mg/kg (OECD Test Guideline 402)
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: m-tolylidene diisocyanate
Result: Irritating to skin. - 24 h Remarks: (RTECS)
Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Result: Irritating to eyes. (Draize Test)
Remarks: (ECHA)
Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
May cause allergy or asthma symptoms or breathing difficulties if inhaled. Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471
Result: positive
Test Type: In vivo micronucleus test Species: Rat
Application Route: Inhalation
Method: Mutagenicity (micronucleus test) Result: negative
Test Type: unscheduled DNA synthesis assay Species: Rat
Application Route: Inhalation Result: negative
Remarks: (ECHA)
Test Type: Micronucleus test Species: Mouse
Application Route: Inhalation Method: OECD Test Guideline 474 Result: negative
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Toxicity
(OECD Test Guideline 203)
Remarks: (in analogy to similar products)
static test EC50 - Daphnia magna (Water flea) - 12,5 mg/l - 48 h (OECD Test Guideline 202)
Remarks: (in analogy to similar products)
Remarks: (in analogy to similar products)
(OECD Test Guideline 209)
Remarks: (in analogy to similar products)
Persistence and degradability
Biodegradability aerobic Biochemical oxygen demand - Exposure time 28 d Result: 0 % - Not biodegradable.
(OECD Test Guideline 302C)
Remarks: (in analogy to similar compounds)
Bioaccumulative potential
Bioaccumulation Cyprinus carpio (Carp) - 60 d
at 24,8 °C - 0,8 mg/l(4-methyl-m-phenylene diisocyanate)
Bioconcentration factor (BCF): 180 (OECD Test Guideline 305)
Mobility in soil
No data available
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
Harmful to aquatic life with long lasting effects.
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
IncompatibilitiesContact with strong oxidizers may cause fires and explosions. Contact with water, acids, bases, and amines can lead to reactions that liberate heat and CO2 and cause violent foaming and spattering. TDI will attack some forms of plastic, rubber, and coatings.
Waste DisposalExcess TDI and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines.
Contaminated packaging
Dispose of as unused product.
UN number
ADR/RID: 2078 IMDG: 2078 IATA: 2078
UN proper shipping name
| | ADR/RID: TOLUENE DIISOCYANATE IMDG: TOLUENE DIISOCYANATE | |
| IATA: Toluene diisocyanate | ||
| 14.3 | Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 | IATA: 6.1 |
| 14.4 | Packaging group ADR/RID: II IMDG: II | IATA: II |
| 14.5 | Environmental hazards ADR/RID: no IMDG Marine pollutant: no | IATA: no |
| 14.6 | Special precautions for user No data available | |
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- CAS: Chemical Abstracts Service
- EC50: Effective Concentration 50%
- IATA: International Air Transportation Association
- IMDG: International Maritime Dangerous Goods
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- STEL: Short term exposure limit
- TWA: Time Weighted Average
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
Other Information
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.