methoxyflurane
Product identifier
- Product name: methoxyflurane
- CBnumber: CB6314297
- CAS: 76-38-0
- EINECS Number: 200-956-0
- Synonyms: mof,MoZ
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Not classified.
Label elements
Pictogram(s)
-
Signal word
Warning
H226 Flammable liquid and vapour
H319 Causes serious eye irritation
H341 Suspected of causing genetic defects
P201 Obtain special instructions before use.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
none
none
none
none
Other hazards
no data available
Substance
- Product name: methoxyflurane
- Synonyms: mof,MoZ
- CAS: 76-38-0
- EC number: 200-956-0
- MF: C3H4Cl2F2O
- MW: 164.97
Description of first aid measures
If inhaledFresh air, rest.
Rinse skin with plenty of water or shower.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Refer for medical attention .
Most important symptoms and effects, both acute and delayed
Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Irritation eyes; central nervous system depression, analgesia, anesthesia, convulsions, respiratory depression; liver, kidney injury Target Organs: Eyes, central nervous system, liver, kidneys, reproductive system (NIOSH, 2016)
Indication of any immediate medical attention and special treatment needed
Absorption, Distribution and ExcretionElimination: Primary: 35% excreted unchanged by exhalation.
Extinguishing media
Fires involving this compound can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
Specific Hazards Arising from the Chemical
This chemical is combustible. (NTP, 1992)
Advice for firefighters
Use water spray, powder, foam, carbon dioxide.
NFPA 704
| HEALTH | 4 | Very short exposure could cause death or major residual injury (e.g. hydrogen cyanide, phosgene, methyl isocyanate, hydrofluoric acid) | |
| FIRE | 2 | Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable metal containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable metal containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
Precautions for safe handling
NO open flames. Above 63°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
Control parameters
Occupational Exposure limit values| Component | Methoxyflurane | |||
|---|---|---|---|---|
| CAS No. | 76-38-0 | |||
| Limit value - Eight hours | Limit value - Short term | |||
| ppm | mg/m3 | ppm | mg/m3 | |
| Austria | 2 | 14 | 4 | 28 |
| Canada - Ontario | 2 | 13 | ? | ? |
| Denmark | 2 | 14 | 4 | 28 |
| USA - NIOSH | ? | ? | 2 (1) | 13,5 (1) |
| Remarks | ||||
| USA - NIOSH | (1) Ceiling limit value | |||
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear safety spectacles or eye protection in combination with breathing protection.
Protective gloves.
Use ventilation, local exhaust or breathing protection.
no data available
Information on basic physicochemical properties
- Physical state
PHYSICAL DESCRIPTION: Clear colorless liquid with a sweet fruity odor. (NTP, 1992)
- Colour
Liquid
- Odour
Fruity
- Melting point/freezing point
-36°C
- Boiling point or initial boiling point and boiling range
103°C
- Flammability
Combustible Liquid
- Lower and upper explosion limit/flammability limit
no data available
- Flash point
63°C
- Auto-ignition temperature
no data available
- Decomposition temperature
no data available
- pH
no data available
- Kinematic viscosity
no data available
- Solubility
less than 1 mg/mL at 66° F (NTP, 1992)
- Partition coefficient n-octanol/water
2.21
- Vapour pressure
20 mm Hg at 63.9° F ; 22.5 mm Hg at 68° F (NTP, 1992)
- Density and/or relative density
1.44
- Relative vapour density
(air = 1): 5.7
- Particle characteristics
no data available
Reactivity
Decomposes on burning. This produces toxic fumes of hydrogen chloride and hydrogen fluoride. Attacks some forms of plastic and rubber.
Chemical stability
no data available
Possibility of hazardous reactions
METHOXYFLURANE may be sensitive to prolonged exposure to light.
Conditions to avoid
no data available
Incompatible materials
STABILITY: This compound may be sensitive to prolonged exposure to light. Solutions of this compound in water, DMSO, 95% ethanol or acetone should be stable for 24 hours under normal laboratory conditions. (NTP, 1992)
Hazardous decomposition products
no data available
Acute toxicity
- Oral: no data available
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
Exposure at high levels could cause unconsciousness.
STOT-repeated exposure
The substance may have effects on the kidneys. This may result in kidney impairment.
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
no data available
Bioaccumulative potential
An estimated BCF of 10 was calculated for methoxyflurane(SRC), using a log Kow of 2.21(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
The Koc of methoxyflurane is estimated as 380(SRC), using a log Kow of 2.21(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that methoxyflurane is expected to have moderate mobility in soil.
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: UN3271 (For reference only, please check.)
IMDG: UN3271 (For reference only, please check.)
IATA: UN3271 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: ETHERS, N.O.S. (For reference only, please check.)
IMDG: ETHERS, N.O.S. (For reference only, please check.)
IATA: ETHERS, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 3 (For reference only, please check.)
IMDG: 3 (For reference only, please check.)
IATA: 3 (For reference only, please check.)
Packing group, if applicable
ADR/RID: II (For reference only, please check.)
IMDG: II (For reference only, please check.)
IATA: II (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.