DIISOPROPYL METHYLPHOSPHONATE
Product identifier
- Product name: DIISOPROPYL METHYLPHOSPHONATE
- CBnumber: CB5449536
- CAS: 1445-75-6
- EINECS Number: 215-896-0
- Synonyms: DIMP,Diisopropyl methylphosphonate
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Label elements
Pictogram(s)
-
Signal word
Warning
H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
none
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: DIISOPROPYL METHYLPHOSPHONATE
- Synonyms: DIMP,Diisopropyl methylphosphonate
- CAS: 1445-75-6
- EC number: 215-896-0
- MF: C7H17O3P
- MW: 180.18
Description of first aid measures
If inhaledMove the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms and effects, both acute and delayed
no data available
Indication of any immediate medical attention and special treatment needed
No studies were located for reducing absorption in humans or animals exposed to diisopropyl methylphosphonate. Standard methods such as cathartics or activated carbon could be used. However, exposure would have to be identified within 4-6 hr since diisopropyl methylphosphonate is rapidly absorbed for the GI tract ... Common methods for reducing dermal absorption ... incl removing contaminated clothes and washing contacted skin with soap and water ... Following eye contact ... eyes should be flushed with copious amt of water.
Extinguishing media
Use dry chemical, carbon dioxide or alcohol-resistant foam.
Specific Hazards Arising from the Chemical
no data available
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
NFPA 704
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
Control parameters
Occupational Exposure limit valuesno data available
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
Information on basic physicochemical properties
- Physical stateliquid
- Colour
no data available
- Odour
no data available
- Melting point/freezing point
no data available
- Boiling point or initial boiling point and boiling range
50°C (1 torr)
- Flammability
no data available
- Lower and upper explosion limit/flammability limit
no data available
- Flash point
97.7°C
- Auto-ignition temperature
no data available
- Decomposition temperature
no data available
- pH
no data available
- Kinematic viscosity
no data available
- Solubility
In water, 1.50X10+3 mg/l @ 25 deg C
- Partition coefficient n-octanol/water
log Kow= 1.03
- Vapour pressure
0.000475mmHg at 25°C
- Density and/or relative density
0.976
- Relative vapour density
no data available
- Particle characteristics
no data available
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
no data available
Acute toxicity
- Oral: LD50 Rat oral 826 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: No data from cancer bioassays or epidemiological studies are available. HUMAN CARCINOGENICITY DATA: None. ANIMAL CARCINOGENICITY DATA: There are no lifetime (chronic) bioassays evaluating carcinogenicity.
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
No biodegradation was observed when diisopropyl methylphosphonate was incubated in natural water for 12 weeks or in aqueous medium inoculated with soil microorganisms for 6 weeks(1). Additionally, diisopropyl methylphosphonate degradation was not observed when other carbon sources such as glucose, glycerol and succinate were added to the medium. When diisopropyl methylphosphonate was incubated in soil at 25 degC, slow biodegradation occurred as was evidenced by the evolution of 14-CO2(1). Approximately 1.5% and 5% of the carbon was released as CO2 after 17 weeks in unacclimated and acclimated soil, respectively. The rate limiting step is the enzymatic hydrolysis of diisopropyl methylphosphonate to isopropyl methylphosphonic acid. The estimated half-lives are 1 and 3 years in acclimated and unacclimated soil, respectively(1). When the soil temperature was reduced to 10 degC, no biodegradation was observed. Another soil sample released 13.4% of its original activity as CO2 after 34 weeks of incubation, indicating a half-life of 2 years(1).
Bioaccumulative potential
An estimated BCF of 1.2 was calculated for diisopropyl methylphosphonate(SRC), using a log Kow of 1.03(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low. Experimental results with bluegill sunfish confirm that diisopropyl methylphosphonate does not bioconcentrate in fish(5). Diisopropyl methylphosphonate did not concentrate in the adipose tissue of ducks or quail(4). The lack of bioconcentration may be a result of metabolism, which is known to occur in mammals and birds(6,7).
Mobility in soil
The Koc of diisopropyl methylphosphonate is estimated as 87(SRC), using a log Kow of 1.03(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that diisopropyl methylphosphonate is expected to have high mobility in soil. A 13% reduction in diisopropyl methylphosphonate concn occurred when diisopropyl methylphosphonate-containing medium was circulated for 32 days in a soil percolator to acclimate the soil microorganisms(5). The investigators speculated that adsorption, rather than biodegradation, was responsible for the diisopropyl methylphosphonate reduction because no further diisopropyl methylphosphonate loss occurred during an additional 18 weeks of operation(5). The mobility of diisopropyl methylphosphonate in soil is evidenced by the detection of diisopropyl methylphosphonate in groundwater at the Rocky Mountain Arsenal(4,6). The source of contamination was a waste-disposal pond.
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: no data available
IMDG: no data available
IATA: no data available
UN Proper Shipping Name
ADR/RID: no data available
IMDG: no data available
IATA: no data available
Transport hazard class(es)
ADR/RID: no data available
IMDG: no data available
IATA: no data available
Packing group, if applicable
ADR/RID: no data available
IMDG: no data available
IATA: no data available
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.