4-Vinylcyclohexene dioxide
Product identifier
- Product name: 4-Vinylcyclohexene dioxide
- CBnumber: CB4213606
- CAS: 106-87-6
- EINECS Number: 203-437-7
- Synonyms: VCD,4-Vinylcyclohexene dioxide
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 3, Dermal
Acute toxicity - Category 3, Inhalation
Carcinogenicity, Category 2
Label elements
Pictogram(s)
- Signal wordDanger
H301 Toxic if swalloed
H311 Toxic in contact with skin
H331 Toxic if inhaled
H351 Suspected of causing cancer
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P203 Obtain, read and follow all safety instructions before use.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P318 IF exposed or concerned, get medical advice.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: 4-Vinylcyclohexene dioxide
- Synonyms: VCD,4-Vinylcyclohexene dioxide
- CAS: 106-87-6
- EC number: 203-437-7
- MF: C8H12O2
- MW: 140.18
Description of first aid measures
If inhaledFresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention .
Most important symptoms and effects, both acute and delayed
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Target Organs: Eyes, skin, respiratory system, blood, thymus, reproductive system (NIOSH, 2016)
Indication of any immediate medical attention and special treatment needed
Absorption, Distribution and Excretion4-Vinyl-1-cyclohexene diepoxide is absorbed by rodents exposed dermally orally, or by inhalation. ... Rats and mice received 0.1 ml and 0.01 ml, respectively, of dose mixtures containing 500 mg/ml (200 uc/ml) [ethylene-(14)C] 4-vinyl-1-cyclohexene diepoxide in acetone. The preliminary results indicate that 30% of the dose applied to the skin is absorbed over a 24 hr period for both rats and mice; only 1%-3% of the dose remained on the skin at the site of application. By 24 hr, 70%-80% of the absorbed dose had been eliminated from the body, virtually all in the urine. The radioactivity remaining in the body was distributed over a number of tissues, with no tissue containing more than 1% of the applied dose. The liver, muscle, and adipose tissue, however, contained 0.5%-1.6% and 1.2%-2.9% of the absorbed dose in rat and mouse tissue, respectively. Tissue to blood ratios ranged from 0.3 to 1.5 in rats and from 0.8 to 2.8 in mice.
Extinguishing media
To fight fire: Water, foam, dry chemical.
Specific Hazards Arising from the Chemical
This chemical is combustible. (NTP, 1992)
Advice for firefighters
Use water spray, powder, alcohol-resistant foam, carbon dioxide.
Personal precautions, protective equipment and emergency procedures
Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking liquid in sealable containers. Wash away remainder with plenty of water.
Environmental precautions
Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking liquid in sealable containers. Wash away remainder with plenty of water.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from food and feedstuffs, alcohols, amines and other active hydrogen compounds. Dry. Ventilation along the floor.
Control parameters
Occupational Exposure limit valuesTLV: 0.1 ppm as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans).MAK: skin absorption (H); carcinogen category: 2
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
Information on basic physicochemical properties
- Physical stateColorless or pale yellow liquid
- Colour
COLORLESS LIQUID
- Odour
no data available
- Melting point/freezing point
-109°C
- Boiling point or initial boiling point and boiling range
227°C at 760mmHg
- Flammability
Class IIIB Combustible Liquid: Fl.P. at or above 200°F.
- Lower and upper explosion limit/flammability limit
no data available
- Flash point
86.4°C
- Auto-ignition temperature
393°C
- Decomposition temperature
no data available
- pH
no data available
- Kinematic viscosity
7.77 CP @ 20 DEG C
- Solubility
50 to 100 mg/mL at 72° F (NTP, 1992)
- Partition coefficient n-octanol/water
1.3
- Vapour pressure
0.119mmHg at 25°C
- Density and/or relative density
1.227g/cm3
- Relative vapour density
4.07 (NTP, 1992) (Relative to Air)
- Particle characteristics
no data available
Reactivity
NIOSH considers vinyl cyclohexene to be a potential occupational carcinogen.
The substance polymerizes with acids and bases. This generates fire or explosion hazard. On combustion, forms acrid smoke and irritating fumes. Reacts with active hydrogen compounds such as alcohols and amines.
Chemical stability
Slowly hydrolyzed in water
Possibility of hazardous reactions
Slight, when exposed to heat or flame.1-VINYL-3-CYCLOHEXENE DIOXIDE reacts with active hydrogen compounds (such as alcohols and amines). (NTP, 1992). Epoxides are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts.
Conditions to avoid
no data available
Incompatible materials
Alcohols, amines, water [Note: Slowly hydrolyzes in water].
Hazardous decomposition products
no data available
Acute toxicity
- Oral: LD50 Rat oral 2.8 g/kg
- Inhalation: LC50 Rat oral inhalation 800 ppm/4 hr
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: There is inadequate evidence in humans for the carcinogenicity of 4-vinylcyclohexene diepoxide. There is sufficient evidence in experimental animals for the carcinogenicity of 4-vinylcyclohexene diepoxide. Overall evaluation: 4-Vinylcyclohexene diepoxide is possibly carcinogenic to humans (Group 2B).
Reproductive toxicity
no data available
STOT-single exposure
The substance is irritating to the eyes, skin and respiratory tract. Inhalation may cause lung oedema. Exposure at high levels could cause death. The effects may be delayed. Medical observation is indicated. See Notes.
STOT-repeated exposure
The substance may have effects on the kidneys, ovary and testes. This may result in tissue lesions. This substance is possibly carcinogenic to humans. Animal tests show that this substance possibly causes toxic effects upon human reproduction.
Aspiration hazard
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C.
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: UN2810 (For reference only, please check.)
IMDG: UN2810 (For reference only, please check.)
IATA: UN2810 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: TOXIC LIQUID, ORGANIC, N.O.S. (For reference only, please check.)
IMDG: TOXIC LIQUID, ORGANIC, N.O.S. (For reference only, please check.)
IATA: TOXIC LIQUID, ORGANIC, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered.
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.