4-Chloro-3-methylphenol
Product identifier
- Product name: 4-Chloro-3-methylphenol
- CBnumber: CB5703115
- CAS: 59-50-7
- EINECS Number: 200-431-6
- Synonyms: CHLOROCRESOL,4-Chloro-3-methylphenol
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: 4-Chloro-3-methylphenol
- Synonyms: CHLOROCRESOL,4-Chloro-3-methylphenol
- CAS: 59-50-7
- EC number: 200-431-6
- MF: C7H7ClO
- MW: 142.58
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides Hydrogen chloride gas Combustible.
Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Further information
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Personal protective equipmentUse equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm Break through time: 480 min
Material tested:KCL 741 Dermatril? L
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Splash contact Material: Nitrile rubber
Minimum layer thickness: 0,11 mm Break through time: 480 min
Material tested:KCL 741 Dermatril? L
protective clothing
Recommended Filter type: Filter A-(P2)
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Do not let product enter drains.
Information on basic physicochemical properties
- Appearancecolorless solid
- Odourcharacteristic
- Odour ThresholdNo data available
- pH5,25 at 30 °C
- Melting point/freezing pointMelting point/range: 63 - 65 °C - lit.
- Initial boiling point and boiling range235 °C - lit.
- Flash point118,0 °C - closed cup - DIN 51758
- Evaporation rateNo data available
- Flammability (solid, gas)The product is not flammable.
- Upper/lower flammability or explosive limitsNo data available
- Vapour pressure 6,9 hPa at 100,0 °C 0,1 hPa at 20,0 °C
- Vapour density No data available
- Relative densityNo data available
- Water solubility4 g/l at 30 °C - soluble
- Partition coefficient: n-octanol/waterlog Pow: 0,47 at 30 °C - Bioaccumulation is not expected.
- Autoignition temperature590,0 °C
- Decomposition temperature200,0 °C -
- ViscosityViscosity, kinematic: No data available Viscosity, dynamic: No data available
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
- Henry's Law Constant2.5(x 10-6 atm?m3/mol)at 20 °C (calculated, Mabey et al., 1982)
Other safety information
Surface tension 61,49 mN/m at 1g/l at 20 °C
-
Surface tension
Dissociation constant 9,4 at 20 °C
-
OECD Test Guideline 112
Reactivity
Forms explosive mixtures with air on intense heating.
A range from approx. 15 Kelvin below the flash point is to be rated as critical.
The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
Violent reactions possible with:
Oxidizing agents Acid anhydrides acid halides Bases
Conditions to avoid
Strong heating.
Incompatible materials
Copper, Copper alloys, brass, Mild steel
Hazardous decomposition products
In the event of fire: see section 5
Information on toxicological effects
Acute toxicity(OECD Test Guideline 401)
LC50 Inhalation - Rat - male and female - 4 h - > 2,87 mg/l (OECD Test Guideline 403)
Symptoms: Possible damages:, Lung edema, mucosal irritations LD50 Dermal - Rat - female - 2.000 mg/kg
(OECD Test Guideline 402)
Result: Corrosive after 1 to 4 hours of exposure (OECD Test Guideline 404)
Result: Causes burns. - 24 h (OECD Test Guideline 405) Remarks:
Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Result: positive
(OECD Test Guideline 406)
Result: negative Ames test
S. typhimurium Result: negative
In vitro mammalian cell gene mutation test Chinese hamster ovary cells
Result: negative
OECD Test Guideline 474
Mouse - male and female - Bone marrow Result: negative
Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2) Acute inhalation toxicity - Possible damages:, Lung edema, mucosal irritations
Toxicity
mg/l - 96 h (US-EPA)
static test EC50 - Daphnia magna (Water flea) - 2,29 mg/l - 48 h (US-EPA)
(OECD Test Guideline 201)
static test NOEC - Desmodesmus subspicatus (green algae) - 9,8 mg/l - 72 h
(OECD Test Guideline 201)
(OECD Test Guideline 209)
Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 85 % - Readily biodegradable. (OECD Test Guideline 301D)
Theoretical oxygen demand
1.852 mg/g
Bioaccumulative potential
Bioaccumulation Cyprinus carpio (Carp) - 6 Weeks
at 25 °C - 0,002 mg/l(chlorocresol)
Bioconcentration factor (BCF): 5,5 - 11
Mobility in soil
No data available
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
Discharge into the environment must be avoided.
Waste treatment methods
Chlorocresol can decompose on contact with strong alkalis, evolving heat and fumes that ignite explosively. It is also incompatible with oxidizing agents, copper, and with solutions of calcium chloride, codeine phosphate, diamorphine hydrochloride, papaveretum, and quinine hydrochloride.
Product
See www.retrologistik.com for processes regarding the return of chemicals and
containers, or contact us there if you have further questions.
Waste DisposalA good candidate for rotary kiln incineration at a temperature range of 820 to 1600C and residence times of seconds for liquids and gases, and hours for solids.
UN number
ADR/RID: 3437 IMDG: 3437 IATA: 3437
UN proper shipping name
ADR/RID: CHLOROCRESOLS, SOLID (chlorocresol)
IMDG: CHLOROCRESOLS, SOLID (chlorocresol) IATA: Chlorocresols, solid (chlorocresol)
Transport hazard class(es)
ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1
Packaging group
ADR/RID: II IMDG: II IATA: II
Environmental hazards
ADR/RID: yes IMDG Marine pollutant: yes IATA: no
Special precautions for user
No data available
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- CAS: Chemical Abstracts Service
- EC50: Effective Concentration 50%
- IATA: International Air Transportation Association
- IMDG: International Maritime Dangerous Goods
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- STEL: Short term exposure limit
- TWA: Time Weighted Average
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.