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Planta medica

Planta medica

IF: 2.1
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Rosmarinic Acid--Pharmaceutical and Clinical Aspects.

Published:1 March 2016 DOI: 10.1055/s-0035-1568274 PMID: 26845712
Solomon K S Amoah,?Louis P Sandjo,?Jadel M Kratz,?Maique W Biavatti

Abstract

The biosynthesis and biotechnological production of Rosmarinic acid, a phenolic ester that is widespread in the plant kingdom, has been widely investigated. This compound has shown many remarkable biological and pharmacological activities, which have led to its pharmaceutical and analytical development, as well as clinical studies, which are summarized and analyzed here for the first time. This review compiles data from the Pubmed, Scopus, Scifinder, Web Of Science, and Science Direct databases published between 1990 and 2015, restricting the search to works with the keywords "Rosmarinic acid" in the title. The initial search identified more than 800 articles; after an initial screening and removal of duplicate works, the search was further refined, resulting in approximately 300 articles that were scrutinized and comprise this review. The articles were organized to describe extraction and isolation, analytical methods, pharmaceutical development, and biological and pharmacological activities [divided into nonclinical (in vitro, in vivo) and clinical studies], pharmacokinetic studies, and stability studies.

Substances (1)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Rosmarinic acid 20283-92-5 C18H16O8 561 suppliers $17.00-$1187.20

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