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ChemicalBook >> journal list >> Biochimica et biophysica acta. Proteins and proteomics >>article
Biochimica et biophysica acta. Proteins and proteomics

Biochimica et biophysica acta. Proteins and proteomics

IF: 2.5
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d-Alanine: Distribution, origin, physiological relevance, and implications in disease

Published:1 November 2020 DOI: 10.1016/j.bbapap.2020.140482 PMID: 32640293
Cindy J. Lee , Tian A. Qiu , Jonathan V. Sweedler

Abstract

d-Alanine (d-Ala) is an unusual endogenous amino acid present in invertebrates and vertebrates. Compared to its l-isomer, the characterization of d-Ala is challenging because of the need for chiral resolution and the low amounts of the d-enantiomer present. With recent improvements in measurement capabilities, research on d-Ala, along with other d-amino acids, has been growing, especially as the functional significance of d-Ala in the mammalian nervous and endocrine systems is becoming known. Here we provide an overview of the distribution, origin, function, and disease implications of d-Ala.

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